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Literature summary for 1.1.5.3 extracted from
- Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin (2012), Physiol. Res., 61, 259-265.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome c | role of cyt c in activation of glycerol-3-phosphate and succinate oxidation in frozenthawed mitochondria | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Digitonin | strong inhibition, the activity is recovered to 148% of control values by the addition of exogenous synthetic analog of CoQ idebenone, i.e. hydroxydecylubiquinone, and cytochrome c. The compound also strongly activates glycerol-3-phosphate oxidation inhibited by endogenous or added free fatty acids | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycerol 3-phosphate + oxidized coenzyme Q | Rattus norvegicus | - |
glycerone phosphate + reduced coenzyme Q | - |
? | |
| sn-glycerol 3-phosphate + oxidized coenzyme Q | Rattus norvegicus Wistar | - |
glycerone phosphate + reduced coenzyme Q | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus Wistar | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | very low activity | Rattus norvegicus | - |
| thyroid gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycerol 3-phosphate + oxidized coenzyme Q | - |
Rattus norvegicus | glycerone phosphate + reduced coenzyme Q | - |
? | |
| sn-glycerol 3-phosphate + oxidized coenzyme Q | - |
Rattus norvegicus Wistar | glycerone phosphate + reduced coenzyme Q | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| flavoprotein-dependent glycerol-3-phosphate dehydrogenase | - |
Rattus norvegicus |
| glycerol-3-phosphate oxidoreductase | - |
Rattus norvegicus |
| GPDH | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| coenzyme Q | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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