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1.1.5.3: glycerol-3-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.5.3

Reaction

sn-glycerol 3-phosphate
+
a quinone
=
glycerone phosphate
 +
a quinol

Synonyms

DsFAD-GPDH, EC 1.1.2.1, EC 1.1.99.5, FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-G3PDH, FAD-glycerol phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol-3-phosphate dehydrogenase, flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate ubiquinone oxidoreductase, flavoprotein-dependent glycerol-3-phosphate dehydrogenase, G3PD, GDP, GLPD, GlpO, glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerol-3-phosphate dehydrogenase 2, glycerol-3-phosphate oxidoreductase, glycerophosphate dehydrogenase, GmGPDH12, GPD1, GPD2, GPDH, mGPDH, mitochondrial glycerol-3-phosphate dehydrogenase, mitochondrial sn-glycerol 3-phosphate dehydrogenase, mtG3PDH, putG3PDH, SDP6, sn-glycerol 3-phosphate dehydrogenase, sn-glycerol-3-phosphate dehydrogenase, ZmGPDH6

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.3 glycerol-3-phosphate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.5.3 - glycerol-3-phosphate dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2MoO4
-
-
1,10-phenanthroline
1,2-Dihydroxybenzene 3,5-disulfonic acid
-
-
1-(2-Thenoyl)-3,3,3-trifluoroacetone
-
-
2,2-dimethyl-5-nitro-2H-benzimidazole
-
-
2-[(7-nitro-3-oxo-2,1,3l5-benzoxadiazol-4-yl)oxy]phenol
-
-
2-[(E)-(4-hydroxyphenyl)diazenyl]-1-benzothiophene-3-ol
-
-
4-(4-chloroanilino)-4-oxobutanoic acid
4-(4-methylanilino)-4-oxobutanoic acid
4-(hexylamino)-4-oxobutanoic acid
4-[3-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1,3-benzothiazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1,3-benzoxazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1H-naphtho[2,3-d]imidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(5-methyl-1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-[5-(3-carboxypropanamido)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
4-[4-[5-(cyclohexa-2,4-diene-1-carbonyl)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde
-
-
6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol
-
-
adriamycin
-
significant inhibition of reaction with hydrophobic electron acceptors, coenzyme Q or vitamin K3
alpha-tocopheryl succinate
bathophenanthroline
-
-
Cetylpyridinium bromide
-
-
Chloroquine
-
inhibits reaction with coenzyme Q1, no inhibition of the reaction with 2,6-dichloroindophenol
cisplatin
-
-
Cu2+
-
specifically inhibits phenazine methosulfate coupled 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide reduction assay
D-2-Phosphoglyceric acid
-
-
D-3-glycerophosphate
-
-
D-3-phosphoglyceric acid
D-glyceraldehyde 3-phosphate
-
D-glycerol phosphate
-
D-phosphoglyceric acid
-
deoxycholate
-
-
Digitonin
-
strong inhibition, the activity is recovered to 148% of control values by the addition of exogenous synthetic analog of CoQ idebenone, i.e. hydroxydecylubiquinone, and cytochrome c. The compound also strongly activates glycerol-3-phosphate oxidation inhibited by endogenous or added free fatty acids
dihydroxyacetone phosphate
-
-
Ethacrynic acid
-
-
ethyl 4-(3-oxo-1,2-thiazol-2(3H)-yl)benzoate
-
-
FMN
-
reaction with methylene blue
glyceraldehyde 3-phosphate
glyceraldehyde-3-phosphate
competitive inhibitor
glyceric acid 2-phosphate
competitive inhibitor
glycerone phosphate
K3PO4
-
non-competitive
L-Glyceraldehyde 3-phosphate
-
m-Chlorohydroxamate
-
-
methyl 4-(4-methylanilino)-4-oxobutanoate
metronidazole
-
-
N-(3,5-dibromo-4-hydroxyphenyl)-4-methylbenzene-1-sulfonamide
-
-
N-[4-(1H-naphtho[2,3-d]imidazol-2-yl)phenyl]butanamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-2-oxopropanamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-3-methylbutanamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-4-ethoxybenzamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]cyclopropanecarboxamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]furan-2-carboxamide
palmitoyl-CoA
-
phosphoenolpyruvate
Phosphoglycolic acid
-
-
Salicylhydroxamate
-
-
Thenoyltrifluoroacetone
-
-
Triton X100
additional information
-