2.7.1.2: glucokinase

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For detailed information about glucokinase, go to the full flat file.

Word Map on EC 2.7.1.2

2.7.1.2

pancreatic

islet

hepatocytes

hexokinase

mellitus

glycogen

beta-cell

hyperglycemia

glucose-6-phosphatase

fructose

pancreas

phosphoenolpyruvate

maturity-onset

carboxykinase

glucagon

glucose-stimulated

glucose-induced

6-phosphate

triglyceride

gluconeogenesis

phosphofructokinase

hypoglycemic

monogenic

antidiabetic

non-insulin-dependent

pepck

gluconeogenic

c-peptide

ins-1e

insulinomas

glp-1

niddm

insulin-secreting

sulfonylurea

g6pase

glut-2

hyperinsulinemia

glucose-sensing

glucose-dependent

insulin-producing

glucose-lowering

2.7.1.1

2,6-bisphosphate

kcnj11

substrate-2

hyperinsulinism

perivenous

fructokinase

diazoxide

glucose-responsive

Reaction

Synonyms

ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.2 glucokinase

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Results	in table
4	Activating Compound
23614	AA Sequence
1	CAS Registry Number
21	Cloned(Commentary)
16	Cofactor
9	Crystallization (Commentary)
11	General Information
5	General Stability
9	IC50 Value
67	Inhibitors
9	kcat/KM [mM/s]
7	Ki Value [mM]
89	KM Value [mM]
7	Localization
62	Metals/Ions
34	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
141	Organism
27	Pathway
97	PDB ID
26	pH Optimum
10	pH Range
1	pI Value
11	Protein Variants
23	Purification (Commentary)
6	Reaction
1	Reaction Type
61	Reference
3	Source Tissue
22	Specific Activity [micromol/min/mg]
5	Storage Stability
157	Substrates and Products (Substrate)
25	Subunits
43	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
5	Temperature Range [°C]
17	Temperature Stability [°C]
23	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 2.7.1.2 - glucokinase

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25 - 45

2 entries

25 - 50

Shewanella woodyi

B1KD89, B1KDE7, B1KRG2

25°C: about 45% of maximal activity, 50°C: about 25% of maximal activity

759000

38 - 98

Thermotoga maritima

below 10% of maximal activity at 38°C, about 90% of maximal activity at 98°C

661779

additional information

Thermotoga maritima

development of an assay method stable at pH 6.8-8.5 and 75-90°C, overview

654181