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2.7.1.2: glucokinase

This is an abbreviated version!
For detailed information about glucokinase, go to the full flat file.

Word Map on EC 2.7.1.2

Reaction

ATP
+
D-glucose
=
ADP
 +
D-glucose 6-phosphate

Synonyms

ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.2 glucokinase

pH Range

pH Range on EC 2.7.1.2 - glucokinase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5 - 8.5
pH 4.5: about 45% of maximal activity, pH 8.5: about 45% of maximal activity
5 - 9.5
active in a wide range pH 5 to 9.5, sharp loss of activity above pH 9.5
6 - 10.5
-
pH 6.0: about 30% of activity maximum, pH 10.5: about 80% of activity maximum
6 - 8.5
pH 6.0: about 55% of maximal activity, pH 8.5: about 40% of maximal activity
6 - 9
-
pH 6.0: about 55% of activity maximum, pH 9.0: about 75% of activity maximum
6.5 - 8.5
pH 6.5: about 55% of maximal activity, pH 8.5: about 55% of maximal activity
6.8 - 7.7
-
50% activity at pH 6.8 and pH 7.7
7.5 - 9.5
pH 7.5: about 65% of maximal activity, pH 9.5: about 30% of maximal activity
additional information
-
development of an assay method stable at pH 6.8-8.5 and 75-90°C, overview