2.7.1.2: glucokinase
This is an abbreviated version!
For detailed information about glucokinase, go to the full flat file.
Word Map on EC 2.7.1.2
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2.7.1.2
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pancreatic
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islet
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hepatocytes
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hexokinase
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mellitus
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glycogen
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beta-cell
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hyperglycemia
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glucose-6-phosphatase
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fructose
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pancreas
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phosphoenolpyruvate
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maturity-onset
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carboxykinase
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glucagon
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glucose-stimulated
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glucose-induced
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6-phosphate
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triglyceride
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gluconeogenesis
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phosphofructokinase
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hypoglycemic
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monogenic
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antidiabetic
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non-insulin-dependent
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pepck
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gluconeogenic
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c-peptide
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ins-1e
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insulinomas
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glp-1
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niddm
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insulin-secreting
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sulfonylurea
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g6pase
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glut-2
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hyperinsulinemia
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glucose-sensing
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glucose-dependent
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insulin-producing
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glucose-lowering
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2.7.1.1
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2,6-bisphosphate
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kcnj11
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substrate-2
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hyperinsulinism
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perivenous
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fructokinase
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diazoxide
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glucose-responsive
- 2.7.1.2
- pancreatic
- islet
- hepatocytes
- hexokinase
- mellitus
- glycogen
- beta-cell
- hyperglycemia
- glucose-6-phosphatase
- fructose
- pancreas
- phosphoenolpyruvate
-
maturity-onset
-
carboxykinase
- glucagon
-
glucose-stimulated
-
glucose-induced
- 6-phosphate
- triglyceride
-
gluconeogenesis
-
phosphofructokinase
-
hypoglycemic
-
monogenic
-
antidiabetic
-
non-insulin-dependent
- pepck
-
gluconeogenic
- c-peptide
-
ins-1e
- insulinomas
- glp-1
- niddm
-
insulin-secreting
- sulfonylurea
- g6pase
-
glut-2
- hyperinsulinemia
-
glucose-sensing
-
glucose-dependent
-
insulin-producing
-
glucose-lowering
-
2.7.1.1
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2,6-bisphosphate
-
kcnj11
- substrate-2
- hyperinsulinism
-
perivenous
- fructokinase
- diazoxide
-
glucose-responsive
Reaction
Synonyms
ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090
ECTree
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Subunits
Subunits on EC 2.7.1.2 - glucokinase
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dimer
homodimer
monomer
tetramer
additional information
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x * 46000, the enzyme may occur as a monomer or dimer, dependent on the protein concentration, SDS-PAGE
?
x * 35500, SDS-PAGE, multimeric protein consisting of di-, tri-, tetra-, penta- and hexamers
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x * 35500, SDS-PAGE, multimeric protein consisting of di-, tri-, tetra-, penta- and hexamers
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?
x * 43000, the enzyme may occur as a monomer or dimer, dependent on the protein concentration, SDS-PAGE
2 * 35200, about, mass spectrometry, 2 * 35000, recombinant enzyme, PAGE under oxidative conditions or SDS-PAGE in absence of reductants, the wild-type and mutant enzymes occur as both monomer and homodimer
homodimer
each subunit (both in open conformations) includes the typical small and large domains
1 * 35200, about, mass spectrometry, 1 * 35000, recombinant enzyme, PAGE under reducing conditions or SDS-PAGE in absence of reductants, the wild-type and mutant enzymes occur as both monomer and homodimer
tetramer
SgGlkA is divided into a small alpha/beta domain and a large alpha + beta domain, and it forms a dimer-of-dimer tetrameric configuration
the active site is located in a deep cleft between the 2 domains of each subunit, monomer and dimer structures, overview
additional information
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the active site is located in a deep cleft between the 2 domains of each subunit, monomer and dimer structures, overview