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2.7.1.2: glucokinase

This is an abbreviated version!
For detailed information about glucokinase, go to the full flat file.

Word Map on EC 2.7.1.2

Reaction

ATP
+
D-glucose
=
ADP
 +
D-glucose 6-phosphate

Synonyms

ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.2 glucokinase

Inhibitors

Inhibitors on EC 2.7.1.2 - glucokinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2-deoxy-2-([[(1,1-dioxido-1-benzothiophen-2-yl)methoxy]carbonyl]amino)-beta-D-glucopyranose
-
2-deoxy-2-[[3-(4-hydroxyphenyl)propanoyl]amino]-alpha-D-glucopyranose
186fold selectivity for Trypanosoma cruzi over human enzyme
2-[[(benzyloxy)carbonyl]amino]-2-deoxy-beta-D-glucopyranose
245fold selectivity for Trypanosoma cruzi over human enzyme
4-(4-tert-butylbenzamido)-3',4',6-trichloro[1,1'-biphenyl]-3-carboxylic acid
-
4-(4-tert-butylbenzamido)-3',6-dichloro-4'-fluoro[1,1'-biphenyl]-3-carboxylic acid
-
4-(4-tert-butylbenzamido)-3',6-dichloro[1,1'-biphenyl]-3-carboxylic acid
-
4-(4-tert-butylbenzamido)-6-chloro-3'-nitro[1,1'-biphenyl]-3-carboxylic acid
-
4-(4-tert-butylbenzamido)-6-chloro-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid
-
4-(4-tert-butylbenzamido)-6-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-carboxylic acid
-
6-Amino-6-deoxy-D-glucose
-
noncompetitive to ATP and competitive to glucose
adenosine 5'-diphosphate-polyamidoamine dendrimer
-
product inhibition
-
ATP
the enzyme exists in two states with different catalytic activity, with an apparent transition point at 0.045 mM ATP. At higher ATP concentrations, strong inhibition takes place
beta,gamma-methyleneadenosine 5'-thiophosphate
-
noncompetitive to ATP and uncompetitive to glucose
citrate
1 M, 23% loss of activity
D-fructose 6-phosphate
-
weak
D-glucose 6-phosphate
hydroxyphenyloxopropyl glucosamine
competitive inhibition
KCl
0.2 M, 50% loss of activity
KH2PO4
3 M, 14% loss of activity
N,N'-[furan-2,5-diylbis(2-chloro-4,1-phenylene)]diguanidine
-
N,N'-[furan-2,5-diylbis(3-chloro-4,1-phenylene)]diguanidine
-
N-acetyl-alpha-D-glucosamine
-
-
N-acetylglucosamine
-
weak
N-ethylmaleimide
-
-
p-chlormercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
Pyrophosphate
2 M, 18% loss of activity
trehalose 6-phosphate
-
XTP
-
in presence of ATP
additional information
-