2.7.1.2: glucokinase

This is an abbreviated version!
For detailed information about glucokinase, go to the full flat file.

Word Map on EC 2.7.1.2

2.7.1.2

pancreatic

islet

hepatocytes

hexokinase

mellitus

glycogen

beta-cell

hyperglycemia

glucose-6-phosphatase

fructose

pancreas

phosphoenolpyruvate

maturity-onset

carboxykinase

glucagon

glucose-stimulated

glucose-induced

6-phosphate

triglyceride

gluconeogenesis

phosphofructokinase

hypoglycemic

monogenic

antidiabetic

non-insulin-dependent

pepck

gluconeogenic

c-peptide

ins-1e

insulinomas

glp-1

niddm

insulin-secreting

sulfonylurea

g6pase

glut-2

hyperinsulinemia

glucose-sensing

glucose-dependent

insulin-producing

glucose-lowering

2.7.1.1

2,6-bisphosphate

kcnj11

substrate-2

hyperinsulinism

perivenous

fructokinase

diazoxide

glucose-responsive

Reaction

Synonyms

ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.2 glucokinase

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Results	in table
4	Activating Compound
23614	AA Sequence
1	CAS Registry Number
21	Cloned(Commentary)
16	Cofactor
9	Crystallization (Commentary)
11	General Information
5	General Stability
9	IC50 Value
67	Inhibitors
9	kcat/KM [mM/s]
7	Ki Value [mM]
89	KM Value [mM]
7	Localization
62	Metals/Ions
34	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
141	Organism
27	Pathway
97	PDB ID
26	pH Optimum
10	pH Range
1	pI Value
11	Protein Variants
23	Purification (Commentary)
6	Reaction
1	Reaction Type
61	Reference
3	Source Tissue
22	Specific Activity [micromol/min/mg]
5	Storage Stability
157	Substrates and Products (Substrate)
25	Subunits
43	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
5	Temperature Range [°C]
17	Temperature Stability [°C]
23	Turnover Number [1/s]

KM Value

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KM Value on EC 2.7.1.2 - glucokinase

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0.5 - 0.67

6-N-(carboxyethyl)ATP

2 entries

0.55 - 0.65

6-N-(carboxymethyl)ATP

2 entries

0.38 - 1

6-N-(succinyl)ATP

2 entries

0.5 - 1.25

6-N-[N-(6-aminohexhyl)carbamoyl]ATP

2 entries

0.15

alpha-D-glucose

Geobacillus stearothermophilus

30°C, pH 7.6

641060

0.05 - 3.76

ATP

31 entries

0.56

CTP

Zymomonas mobilis

30°C, pH 7

641057

1.1

D-glucosamine

Methylotuvimicrobium alcaliphilum

G4T1H4

pH 9.5, 30°C

758660

0.028 - 19

D-glucose

38 entries

0.25

GTP

Zymomonas mobilis

30°C, pH 7

641057

0.36

ITP

Zymomonas mobilis

30°C, pH 7

641057

0.63

UTP

Zymomonas mobilis

30°C, pH 7

641057

additional information

7 entries