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2.6.1.19: 4-aminobutyrate-2-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about 4-aminobutyrate-2-oxoglutarate transaminase, go to the full flat file.

Word Map on EC 2.6.1.19

Reaction

4-aminobutanoate
+
2-oxoglutarate
=
succinate semialdehyde
 +
L-glutamate

Synonyms

4-aminobutyrate aminotransferase, 4-aminobutyrate transaminase, 4-aminobutyrate-2-ketoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate transaminase, 4-aminobutyric acid 2-ketoglutaric acid aminotransferase, 4-aminobutyric acid aminotransferase, ABAT, aminobutyrate aminotransferase, aminobutyrate transaminase, aminotransferase, aminobutyrate, argD, argD6803, argD7002, Atu3000, beta-alanine aminotransferase, beta-alanine transaminase, beta-alanine-oxoglutarate aminotransferase, beta-alanine-oxoglutarate transaminase, bioA, CG010_026395, CgGABA-AT, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-2-oxoglutarate aminotransferase, GABA-2-oxoglutarate transaminase, GABA-alpha-ketoglutarate aminotransferase, GABA-alpha-ketoglutarate transaminase, GABA-alpha-ketoglutaric acid transaminase, GABA-alpha-oxoglutarate aminotransferase, GABA-AT, GABA-oxoglutarate aminotransferase, GABA-oxoglutarate transaminase, GABA-T, GABA-T1, GABA-T2, GABA-T3, GABA-TA, GABA-transaminase, GABA:2-oxoglutarate aminotransferase, GABAT, GabT, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate aminotransferase, gamma-aminobutyrate transaminase, gamma-aminobutyrate transaminases, gamma-aminobutyrate-alpha-ketoglutarate aminotransferase, gamma-aminobutyrate-alpha-ketoglutarate transaminase, gamma-aminobutyrate: GABA transaminase, gamma-aminobutyrate:alpha-oxoglutarate aminotransferase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric acid-2-oxoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase, gamma-aminobutyric transaminase, gatT, glutamate-succinic semialdehyde transaminase, homotaurine:2-oxoglutarate aminotransferase, MdGABA-T1, MdGABA-T2, More, NCgl0462, NCgl2515, Osl2, pollen-pistil incompatibility 2, Pop2, SkUga1p, slr1022

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase

KM Value

KM Value on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1 - 1.6
(4R)-4-amino-1-cyclopentene-1-carboxylic acid
0.059
(R)-4-amino-3-fluorobutanoic acid
pH 8.5
0.045
(R,S)-4-amino-3-fluorobutanoic acid
pH 8.5
8
1H-tetrazole-5-butanamine
-
pH 8.5
2.3
1H-tetrazole-5-ethanamine
-
pH 8.5
2.4
1H-tetrazole-5-propanamine
-
pH 8.5
0.0021 - 46
2-oxoglutarate
8.5
3-Aminopropanesulfonate
Km apparent value
1.4
4-(aminomethyl)-1H-pyrrole-2-carboxylic acid
-
pH 8.5, 25°C
0.31
4-(aminomethyl)furan-2-carboxylic acid
-
pH 8.5, 25°C
2.8
4-(aminomethyl)furan-3-carboxylic acid
-
pH 8.5, 25°C
1.7
4-(aminomethyl)thiophene-2-carboxylic acid
-
pH 8.5, 25°C
10
4-(aminomethyl)thiophene-3-carboxylic acid
-
pH 8.5, 25°C
0.077 - 146
4-aminobutanoate
9.9
4-aminobutyrate
Km apparent value
0.014
4-Oxobutanoate
with L-alanine as cosubstrate, in 50 mM TABS (pH 9), 1.5 mM dithiothreitol, 0.625 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 10% (v/v) glycerol, at 30°C
9.5
5-(aminomethyl)-1H-pyrrole-2-carboxylic acid
-
pH 8.5, 25°C
2.49
5-(aminomethyl)furan-2-carboxylic acid
-
pH 8.5, 25°C
6.3
5-(aminomethyl)thiophene-2-carboxylic acid
-
pH 8.5, 25°C
0.1
alpha-ketoglutarate
-
pH 8.4, 25°C
1.05 - 18
beta-Alanine
2.3
DL-3-amino-1-cyclopentene-1-carboxylic acid
-
-
3.2
gamma-aminobutanoate
pH 8.0, 30°C
2.6
gamma-aminobutanoic acid
pH 8.5
0.0165 - 0.11
glyoxylate
2.72
L-3-aminoisobutanoate
-
-
2.4
L-alanine
with 4-oxobutanoate as cosubstrate, in 50 mM TABS (pH 9), 1.5 mM dithiothreitol, 0.625 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 10% (v/v) glycerol, at 30°C
2.9
L-ornithine
-
-
2.5
putrescine
-
-
0.0188 - 0.24
pyruvate
8
tetrazole-5-butanamine
-
at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol
2.3
tetrazole-5-ethanamine
-
at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol
2.4
tetrazole-5-propanamine
-
at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol
additional information
additional information
-