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2.6.1.19: 4-aminobutyrate-2-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about 4-aminobutyrate-2-oxoglutarate transaminase, go to the full flat file.

Word Map on EC 2.6.1.19

Reaction

4-aminobutanoate
+
2-oxoglutarate
=
succinate semialdehyde
 +
L-glutamate

Synonyms

4-aminobutyrate aminotransferase, 4-aminobutyrate transaminase, 4-aminobutyrate-2-ketoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate transaminase, 4-aminobutyric acid 2-ketoglutaric acid aminotransferase, 4-aminobutyric acid aminotransferase, ABAT, aminobutyrate aminotransferase, aminobutyrate transaminase, aminotransferase, aminobutyrate, argD, argD6803, argD7002, Atu3000, beta-alanine aminotransferase, beta-alanine transaminase, beta-alanine-oxoglutarate aminotransferase, beta-alanine-oxoglutarate transaminase, bioA, CG010_026395, CgGABA-AT, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-2-oxoglutarate aminotransferase, GABA-2-oxoglutarate transaminase, GABA-alpha-ketoglutarate aminotransferase, GABA-alpha-ketoglutarate transaminase, GABA-alpha-ketoglutaric acid transaminase, GABA-alpha-oxoglutarate aminotransferase, GABA-AT, GABA-oxoglutarate aminotransferase, GABA-oxoglutarate transaminase, GABA-T, GABA-T1, GABA-T2, GABA-T3, GABA-TA, GABA-transaminase, GABA:2-oxoglutarate aminotransferase, GABAT, GabT, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate aminotransferase, gamma-aminobutyrate transaminase, gamma-aminobutyrate transaminases, gamma-aminobutyrate-alpha-ketoglutarate aminotransferase, gamma-aminobutyrate-alpha-ketoglutarate transaminase, gamma-aminobutyrate: GABA transaminase, gamma-aminobutyrate:alpha-oxoglutarate aminotransferase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric acid-2-oxoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase, gamma-aminobutyric transaminase, gatT, glutamate-succinic semialdehyde transaminase, homotaurine:2-oxoglutarate aminotransferase, MdGABA-T1, MdGABA-T2, More, NCgl0462, NCgl2515, Osl2, pollen-pistil incompatibility 2, Pop2, SkUga1p, slr1022

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase

Crystallization

Crystallization on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified enzyme in complex with GABA and PLP, sitting drop vapor diffusion method, mixing of 0.001 ml of 42 mg/ml protein in 40 mM Tris-HCl, pH 8.0, and 300 mM sodium chloride, with 0.001 ml of reservoir solution containing 25% w/v PEG 3350, 0.1 M Bis-Tris, pH 6.5, and 0.2 M sodium chloride, and equilibration against 0.05 ml of reservoir solution method optimization, 20°C, X-ray diffraction structure determination and analysis at 1.90 A resolution, molecular replacement using the structure of GABA-AT from Paenarthrobacter aurescens TC1 (PDB ID 4ATP) as a search model
in complex with inhibitor aminooxyacetate
mutant I50Q, V241A, E211S
crystal structures of enzyme inactivated by inhibitors (1S,2S,3E)-2-amino-3-(fluoromethylidene)cyclopentanecarboxylic acid and (1S,2S,3Z)-2-amino-3-(fluoromethylidene)cyclopentanecarboxylic acid. The Arg445-Glu270 salt bridge in the active site is disrupted during inactivation, and Glu270 rotates away from its original position to accommodate a weak electrostatic or hydrogen-bonding interaction between the formyl group of a metabolite and Arg445
docking calculations for substrates 3-(aminomethyl)benzoic acid, [3-(aminomethyl)phenyl]acetic acid and [2-(aminomethyl)phenyl]acetic acid, using the crystallographic structure of the enzyme in complex with vigabatrin
enzyme bound to inhibitor (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, X-ray diffraction structure determination and analysis at 1.95 A resolution
in complex with mechanism-based inhibitor (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid
-
native form and in complex with inhibitor vigabatrin and with 4-ethynyl-4-aminobutanoate