2.5.1.78: 6,7-dimethyl-8-ribityllumazine synthase
This is an abbreviated version!
For detailed information about 6,7-dimethyl-8-ribityllumazine synthase, go to the full flat file.
Word Map on EC 2.5.1.78
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2.5.1.78
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brucella
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capsid
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icosahedral
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aquifex
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aeolicus
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brucellosis
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4-phosphate
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pentamer
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abortus
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3,4-dihydroxy-2-butanone
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5-amino-6-ribitylamino-2,41h,3h-pyrimidinedione
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medicine
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guest
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decameric
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supercharged
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homopentamer
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nanocompartments
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60-subunit
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biotechnology
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synthesis
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molecular biology
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analysis
-
drug development
- 2.5.1.78
- brucella
-
capsid
-
icosahedral
-
aquifex
- aeolicus
- brucellosis
- 4-phosphate
-
pentamer
- abortus
- 3,4-dihydroxy-2-butanone
-
5-amino-6-ribitylamino-2,41h,3h-pyrimidinedione
- medicine
-
guest
-
decameric
-
supercharged
-
homopentamer
-
nanocompartments
-
60-subunit
- biotechnology
- synthesis
- molecular biology
- analysis
- drug development
Reaction
Synonyms
6,7-dimethyl-8-(d-ribityl)lumazine synthase, 6,7-dimethyl-8-ribityllumazine synthase, 6,7-dimethyl-8-ribityllumazine synthase 1, 6,7-dimethyl-8-ribityllumazine synthase 2, 6,7-dimethyl-8-ribityllumazine-synthase, AaLS, BLS, DMRL synthase, DMRL synthase 2, heavy riboflavin synthase, LcLS1, LcLS2, lumazine synthase, lumazine synthase 1, lumazine synthase 2, lumazine synthase/riboflavin synthase complex, lumazinesynthase/riboflavin synthase complex, lumazinesynthase/riboflavin synthase complex, icosahedral capsid of 60 beta subunits enclosing a triplet of alpha subunits, luminazine synthase, MbtLS, MJ0303, Pbls, RIB4, ribE, RibH, ribH1, RibH1 protein, RibH2, type I lumazine synthase, type II lumazine synthase
ECTree
2.5.1.78 6,7-dimethyl-8-ribityllumazine synthaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.5.1.78 - 6,7-dimethyl-8-ribityllumazine synthase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.005
5-nitro-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
native enzyme complex, pH 7.0, 37°C
0.0025
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
isoform RibH1, pH 7.0, 37°C
0.003
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, mutant enzyme W27F
0.003
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, mutant enzyme W27Y
0.0041
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme T80V
0.0042
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme A56S
0.005
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, wild-type enzyme
0.00612
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme F22W
0.00857
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, wild-type enzyme
0.01
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme D138A
0.0107
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme F22V
0.011
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme S142L
0.0115
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme K135A
0.0119
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme N23S
0.0125
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
37°C, pH 7.0
0.0138
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme K131R
0.02
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
isoform RibH2, pH 7.0, 37°C
0.0345
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme F57S
0.0355
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme K131N
0.056
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme H88K
0.0849
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme R127H
0.14
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme F22S
0.147
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
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pH 7.0, 37°C, mutant enzyme H88A
0.173
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme E58Q
0.23
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, mutant enzyme W27I
0.278
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme F113S
0.4
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, mutant enzyme W27H
0.43
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, mutant enzyme W27G
0.46
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
pH 7.0, 37°C, mutant enzyme W27S
0.72
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
-
pH 7.0, 37°C, mutant enzyme F22D
0.0052
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, Tris buffer
0.0067
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, MOPS buffer
0.015
L-3,4-dihydroxybutan-2-one 4-phosphate
isoform RibH1, pH 7.0, 37°C
0.042
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme H88K
0.042
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme T80V
0.05
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme K131R
0.05
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, phosphate buffer
0.05
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, phosphate buffer
0.052
L-3,4-dihydroxybutan-2-one 4-phosphate
37°C, pH 7.0
0.0546
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, wild-type enzyme
0.0581
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme N23S
0.0598
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme F22W
0.06
L-3,4-dihydroxybutan-2-one 4-phosphate
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pH 7.0, 37°C, mutant enzyme H88A
0.0636
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme D138A
0.065
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, mutant enzyme W27F
0.0665
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme F113S
0.067
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, wild-type enzyme
0.0702
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme A56S
0.08
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme F57S
0.086
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, mutant enzyme W27Y
0.0905
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme S142L
0.124
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme F22V
0.137
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme F22S
0.137
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, mutant enzyme W27I
0.145
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, mutant enzyme W27H
0.146
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme E58Q
0.167
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme K135A
0.168
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, mutant enzyme W27G
0.187
L-3,4-dihydroxybutan-2-one 4-phosphate
pH 7.0, 37°C, mutant enzyme W27S
0.283
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme K131N
0.45
L-3,4-dihydroxybutan-2-one 4-phosphate
isoform RibH2, pH 7.0, 37°C
0.675
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme F22D
3.14
L-3,4-dihydroxybutan-2-one 4-phosphate
-
pH 7.0, 37°C, mutant enzyme R127H
additional information
additional information
steady-state kinetics, and kinetic modelling of the interaction of the single enzymes and identification of rate-limiting steps in the biosynthetic pathway, detailed overview
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additional information
additional information
-
steady-state kinetics, and kinetic modelling of the interaction of the single enzymes and identification of rate-limiting steps in the biosynthetic pathway, detailed overview
-
