2.5.1.78: 6,7-dimethyl-8-ribityllumazine synthase

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For detailed information about 6,7-dimethyl-8-ribityllumazine synthase, go to the full flat file.

Reaction

Synonyms

6,7-dimethyl-8-(d-ribityl)lumazine synthase, 6,7-dimethyl-8-ribityllumazine synthase, 6,7-dimethyl-8-ribityllumazine synthase 1, 6,7-dimethyl-8-ribityllumazine synthase 2, 6,7-dimethyl-8-ribityllumazine-synthase, AaLS, BLS, DMRL synthase, DMRL synthase 2, heavy riboflavin synthase, LcLS1, LcLS2, lumazine synthase, lumazine synthase 1, lumazine synthase 2, lumazine synthase/riboflavin synthase complex, lumazinesynthase/riboflavin synthase complex, lumazinesynthase/riboflavin synthase complex, icosahedral capsid of 60 beta subunits enclosing a triplet of alpha subunits, luminazine synthase, MbtLS, MJ0303, Pbls, RIB4, ribE, RibH, ribH1, RibH1 protein, RibH2, type I lumazine synthase, type II lumazine synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.78 6,7-dimethyl-8-ribityllumazine synthase

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Results	in table
39433	AA Sequence
22	Application
34	Cloned(Commentary)
27	Crystallization (Commentary)
1	Expression
26	General Information
2	General Stability
9	IC50 Value
161	Inhibitors
127	Ki Value [mM]
79	KM Value [mM]
3	Localization
37	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
159	Organism
8	Pathway
2300	PDB ID
24	pH Optimum
1	pI Value
4	Posttranslational Modification
46	Protein Variants
20	Purification (Commentary)
2	Reaction
151	Reference
9	Source Tissue
11	Specific Activity [micromol/min/mg]
130	Substrates and Products (Substrate)
111	Subunits
85	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
5	Temperature Stability [°C]
45	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.5.1.78 - 6,7-dimethyl-8-ribityllumazine synthase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

120

Aquifex aeolicus

-

melting temperature: 119.9°C

699512

20

Brucella sp.

-

the higher molecular order of the decameric enzyme increases its stability at 20°C compared with pentameric lumazine synthases

698729

50

Bacillus anthracis

-

lumazine synthase shows two distinct thermal transitions in phosphate containing buffers. The first transition around 50°C is due to the dissociation of phosphate ions from the protein and is reversible and the second strating from 80°C comes from the dissociation and conformational alteration of its icosahedral structure. The highest Tm values for both transitions are at pH 7.0

759652

80

Bacillus anthracis

-

lumazine synthase shows two distinct thermal transitions in phosphate containing buffers. The first transition around 50°C is due to the dissociation of phosphate ions from the protein and is reversible and the second strating from 80°C comes from the dissociation and conformational alteration of its icosahedral structure. The highest Tm values for both transitions are at pH 7.0

759652

88

Brucella sp.

-

melting temperature. The loss of secondary structure is not recovered after slow cooling of the samples, indicating that an irreversible unfolding takes place under these conditions

698729