2.4.2.3: uridine phosphorylase

This is an abbreviated version!
For detailed information about uridine phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.3

2.4.2.3

pyrimidine

nucleoside

thymidine

uracil

5-fluorouracil

phosphorolysis

salvage

orotate

phosphoribosyltransferase

phosphorylases

thymidylate

fluoropyrimidine

udp

5'-deoxy-5-fluorouridine

5-fluoro-2'-deoxyuridine

dihydropyrimidine

acyclonucleoside

5-fluorouridine

ribose-1-phosphate

capecitabine

5-methyluridine

dthdpase

fdurd

orotidine

dihydrouracil

uridine-cytidine

mete

diagnostics

medicine

synthesis

drug development

Reaction

Synonyms

apUP, EC 2.4.2.23, L-UrdPase, More, PcUP1, PcUP2, phosphorylase, uridine, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, StUPh, udp, UDRPase , UP type 1, UP1, UP2, uPA, UPase, UPase-2, UPb, UPH, UPP1, UPP2, UrdPase, uridine phosphorylase, uridine phosphorylase 1, uridine phosphorylase-1, uridine phosphorylase-2, uridine:orthophosphate alpha-D-ribosyltransferase, VchUPh

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.3 uridine phosphorylase

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Results	in table
5	Activating Compound
5766	AA Sequence
9	Application
1	CAS Registry Number
32	Cloned(Commentary)
31	Crystallization (Commentary)
354	Disease/ Diagnostics
7	Expression
19	General Information
4	General Stability
127	Inhibitors
8	kcat/KM [mM/s]
39	Ki Value [mM]
85	KM Value [mM]
10	Localization
2	Metals/Ions
29	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
667	Organism
8	Pathway
483	PDB ID
23	pH Optimum
7	pH Range
1	pH Stability
78	Protein Variants
46	Purification (Commentary)
18	Reaction
3	Reaction Type
127	Reference
1	Renatured (Commentary)
86	Source Tissue
20	Specific Activity [micromol/min/mg]
6	Storage Stability
200	Substrates and Products (Substrate)
35	Subunits
81	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
6	Turnover Number [1/s]

Expression

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Expression on EC 2.4.2.3 - uridine phosphorylase

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PcUP1 is upregulated 300fold within 90 min after infection of pepper leaves

2 entries

PcUP2 is upregulated 500fold within 90 min after infection of pepper leaves

2 entries

the peroxisome proliferator-activated receptor gamma coactivator-1alpha induces the enzyme in cancer cells via binding of a nuclear receptor, leading to enhanced antiproliferative activity of 5-deoxy-5-fluorouridine, overview. The activation is abolished by XCT790, i.e. 3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide. Molecular mechanisms, overview

Homo sapiens

705806

UPP1 expression is significantly downregulated in thyroid cancer

Homo sapiens

Q16831

759543

UPP1 is significantly upregulated in glioma, especially in glioblastoma

Homo sapiens

Q16831

758991