2.4.1.101: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-, alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, AtGnTI, beta-1-2 GlcNAc transferase, ChGnTI, EC 2.4.1.51, GlcNAc transferase I, GlcNAc-T I, GlcNAc-TI, GlcNAcT-I, gly-12, GLY-13, gly-14, GnT I, GnT-I, GnT1, GnTI, Golgi N-glycan branching N-acetylglucosaminyltransferase I, HuGnTI, MGAT1, N-acetylglucosaminyltransferase I, N-acetylglucosaminyltransferases I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, NT, pigGnT-I, PtGnTI, TbGnTI, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, UDP-GlcNac:alpha3-D-mannoside beta1,2-Nacetylglucosaminyltransferase I, UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I, UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine to alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2) beta-1,2-N-acetyl-D-glucosaminyltransferase, UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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Results	in table
9	Activating Compound
2690	AA Sequence
5	Application
1	CAS Registry Number
32	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
3	Expression
36	General Information
4	General Stability
28	Inhibitors
9	Ki Value [mM]
52	KM Value [mM]
45	Localization
82	Metals/Ions
31	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
71	Organism
5	Pathway
7	PDB ID
15	pH Optimum
4	pH Range
1	pH Stability
6	Posttranslational Modification
40	Protein Variants
18	Purification (Commentary)
10	Reaction
1	Reaction Type
68	Reference
47	Source Tissue
15	Specific Activity [micromol/min/mg]
6	Storage Stability
183	Substrates and Products (Substrate)
10	Subunits
112	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.101 - alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein]

UDP + Man5GlcNAc3-[protein]

3 entries

UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

5 entries

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

5 entries

UDP-N-acetyl-D-glucosamine + ovalbumin glycopeptide V

UDP + ovalbumin glycopeptide IIIA

Bos taurus

-

physiological substrate

488362

-

-

?

UDP-N-acetylglucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

Nicotiana tabacum

-

-

694620

-

-

?

additional information

?

-

7 entries

UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein]

UDP + Man5GlcNAc3-[protein]

Arabidopsis thaliana

Q9XGM8

-

760144

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein]

UDP + Man5GlcNAc3-[protein]

Caenorhabditis elegans

G5EBG7, G5EFK6, Q11068

-

758843

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein]

UDP + Man5GlcNAc3-[protein]

Phaeodactylum tricornutum

G0WVT5

-

760144

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Homo sapiens

P26572

-

736200

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Oryctolagus cuniculus

P27115

GlcNAc transfer catalyzed by GnT-I is the first step in the conversion of high mannose oligosaccharides to complex and hybrid N-glycan structures

674191

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Sus scrofa

-

-

671754

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Trypanosoma brucei brucei

-

-

736466

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Trypanosoma brucei brucei 427

-

-

736466

-

-

?

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

Bos taurus

-

stimulates galactosyltransferase of bovine milk

488366

-

-

?

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

Homo sapiens

-

key enzyme of biosynthesis of complex and hybrid N-glycans

488379

-

-

?

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

Oryctolagus cuniculus

-

key enzyme of biosynthesis of complex and hybrid N-glycans

488368

-

-

?

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

Rattus norvegicus

-

key enzyme of biosynthesis of complex and hybrid N-glycans

488359

-

-

?

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide

Xenopus laevis

-

key enzyme of biosynthesis of complex and hybrid N-glycans

488381

-

-

?

additional information

?

-

Arabidopsis thaliana

-

the enzyme is essential for processing of high-mannose to hybrid and complex N-glycans

657862

-

-

?

additional information

?

-

Bos taurus

-

the enzyme catalyzes the first step in the conversion of oligomannose to complex or hybrid N-glycans of glycoproteins

659000

-

-

?

additional information

?

-

Caenorhabditis elegans

-

GLY-13 plays an important role in the synthesis of N-glycans. Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase

657825

-

-

?

additional information

?

-

Cricetulus griseus

-

enzyme initiates the biosynthesis of heparan sulfate

488371

-

-

?

additional information

?

-

Nicotiana benthamiana

-

transformant plants that exhibit specific reduction of GnTI activity below detection limit, do not exhibit significantly altered complex N-glycan structures. Even the undetectable residual GnTI activity is sufficient for the synthesis of complex N-glycans comparable to wild-type plants

658866

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

the enzyme is essential for processing of high-mannose to hybrid and complex N-glycans

657862

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme catalyzes the first step in the conversion of oligomannose to complex or hybrid N-glycans of glycoproteins

658192

-

-

?