2.4.1.101: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-, alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, AtGnTI, beta-1-2 GlcNAc transferase, ChGnTI, EC 2.4.1.51, GlcNAc transferase I, GlcNAc-T I, GlcNAc-TI, GlcNAcT-I, gly-12, GLY-13, gly-14, GnT I, GnT-I, GnT1, GnTI, Golgi N-glycan branching N-acetylglucosaminyltransferase I, HuGnTI, MGAT1, N-acetylglucosaminyltransferase I, N-acetylglucosaminyltransferases I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, NT, pigGnT-I, PtGnTI, TbGnTI, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, UDP-GlcNac:alpha3-D-mannoside beta1,2-Nacetylglucosaminyltransferase I, UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I, UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine to alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2) beta-1,2-N-acetyl-D-glucosaminyltransferase, UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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Results	in table
9	Activating Compound
2690	AA Sequence
5	Application
1	CAS Registry Number
32	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
3	Expression
36	General Information
4	General Stability
28	Inhibitors
9	Ki Value [mM]
52	KM Value [mM]
45	Localization
82	Metals/Ions
31	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
71	Organism
5	Pathway
7	PDB ID
15	pH Optimum
4	pH Range
1	pH Stability
6	Posttranslational Modification
40	Protein Variants
18	Purification (Commentary)
10	Reaction
1	Reaction Type
68	Reference
47	Source Tissue
15	Specific Activity [micromol/min/mg]
6	Storage Stability
183	Substrates and Products (Substrate)
10	Subunits
112	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 2.4.1.101 - alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2'-dUDP

Oryctolagus cuniculus

-

weak

488368

2'-O-Methyl-UDP

Oryctolagus cuniculus

-

weak

488368

5-Bromo-UTP

Oryctolagus cuniculus

-

-

488368

5-Mercury-UDP

Oryctolagus cuniculus

-

-

488368

alpha-D-Mannosyl-1,3-(alpha-D-mannosyl-1,6)-4-O-methyl-beta-D-mannosyl-1,4-N-acetyl-D-glucosamine

Rattus norvegicus

-

weak

488359

alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R

Oryctolagus cuniculus

-

-

488368

Antibodies to pig liver N-acetylglucosaminyltransferase I

Sus scrofa

-

-

488364

-

Ca2+

Homo sapiens

-

-

488379

EDTA

2 entries

Manalpha6(6-O-(4,4-azopentyl)-Manalpha3)Man-beta-octyl

Rattus norvegicus

-

-

659864

Manalpha6(6-O-(4,5-epoxypentyl)-Manalpha3)Man-beta-octyl

Rattus norvegicus

-

-

659864

Manalpha6(6-O-(4-oxopentyl)-Manalpha3)Man-beta-octyl

Rattus norvegicus

-

-

659864

Manalpha6(6-O-(5-pentanolyl)-Manalpha3)Man-beta-octyl

Rattus norvegicus

-

-

659864

Manalpha6(6-O-methyl-Manalpha3)Man-beta-octyl

Rattus norvegicus

-

-

659864

TDP

Oryctolagus cuniculus

-

-

488368

UDP

Oryctolagus cuniculus

-

-

488360, 488368

UDP-glucose

Oryctolagus cuniculus

-

weak

488368

UDP-N-acetylgalactosamine

Oryctolagus cuniculus

-

weak

488368

UDP-N-acetylglucosamine

Oryctolagus cuniculus

-

competitively to UDP

488368

UMP

Oryctolagus cuniculus

-

weak

488368

UTP

Oryctolagus cuniculus

-

weak

488368

Zn2+

Homo sapiens

-

-

488379

[Manalpha6(Manalpha3)][4-O-methyl-Man]-beta4-N-acetyl-D-glucosamine

Rattus norvegicus

-

-

659864

additional information

3 entries

-

EDTA

Bos taurus

-

3 mM

488362

EDTA

Oryctolagus cuniculus

-

3 mM

488360

additional information

Oryctolagus cuniculus

-

high ionic strength, e.g. 0.1 M NaCl

488360

-

additional information

Oryctolagus cuniculus

-

no inhibitors are CDP, UDPhexanolamine, AMP

488368

-

additional information

Rattus norvegicus

-

several inhibitory synthetic acceptor substrate analogues, overview; strategies for inhibitor design based on substrate specificities of the enzyme

488373

-