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2.4.1.101: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.101

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
Man5GlcNAc2-[protein]
=
UDP
+
Man5GlcNAc3-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-, alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, AtGnTI, beta-1-2 GlcNAc transferase, ChGnTI, EC 2.4.1.51, GlcNAc transferase I, GlcNAc-T I, GlcNAc-TI, GlcNAcT-I, gly-12, GLY-13, gly-14, GnT I, GnT-I, GnT1, GnTI, Golgi N-glycan branching N-acetylglucosaminyltransferase I, HuGnTI, MGAT1, N-acetylglucosaminyltransferase I, N-acetylglucosaminyltransferases I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, NT, pigGnT-I, PtGnTI, TbGnTI, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, UDP-GlcNac:alpha3-D-mannoside beta1,2-Nacetylglucosaminyltransferase I, UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I, UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine to alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2) beta-1,2-N-acetyl-D-glucosaminyltransferase, UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Reference

Reference on EC 2.4.1.101 - alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tezuka, K.; Hayashi, M.; Ishihara, H.; Akazawa, T.; Takahashi, N.
Studies on synthetic pathway of xylose-containing N-linked oligosaccharides deduced from substrate specificities of the processing enzymes in sycamore cells (Acer pseudoplatanus L.)
Eur. J. Biochem.
203
401-413
1992
Acer pseudoplatanus
Manually annotated by BRENDA team
Möller, G.; Reck, F.; Paulsen, H.; Kaur, K.J.; Sarkar, M.; Schachter, H.; Brockhausen, I.
Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc: Man-alpha-3R-beta-2-N-acetylglucosaminyltransferase I using synthetic substrate analogs
Glycoconj. J.
9
180-190
1992
Rattus norvegicus
Manually annotated by BRENDA team
Oppenheimer, C.L.; Hill, R.L.
Purification and characterization of a rabbit liver alpha 1-3 mannoside beta 1-2 N-acetylglucosaminyltransferase
J. Biol. Chem.
256
799-804
1981
Oryctolagus cuniculus
Manually annotated by BRENDA team
Mendicino, J.; Chandrasekaran, E.V.; Rao Anumula, K.; Davila, M.
Isolation and properties of alpha-D-mannose: beta-1,2-N-acetylglucosaminyltransferase from trachea mucosa
Biochemistry
20
967-976
1981
Sus scrofa
Manually annotated by BRENDA team
Harpaz, N.; Schachter, H.
Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase II, partial purification, and substrate specificity
J. Biol. Chem.
255
4885-4893
1980
Bos taurus
Manually annotated by BRENDA team
Miyagi, T.; Tsuiki, S.
Studies on UDP-N-acetylglucosamine: alpha-mannoside beta-N-acetylglucosaminyltransferase of rat liver and hepatomas
Biochim. Biophys. Acta
661
148-157
1981
Rattus norvegicus
Manually annotated by BRENDA team
Oppenheimer, C.L.; Eckhardt, A.E.; Hill, R.L.
The nonidentity of porcine N-acetylglucosaminyltransferases I and II
J. Biol. Chem.
256
11477-11482
1981
Sus scrofa
Manually annotated by BRENDA team
Shao, M.C.; Wold, F.
The effect of the protein matrix on glycan processing in glycoproteins. Kinetic analysis of three rat liver Golgi enzymes
J. Biol. Chem.
263
5771-5774
1988
Rattus norvegicus
Manually annotated by BRENDA team
Moscarello, M.A.; Mitranic, M.M.; Vella, G.
Stimulation of bovine milk galactosyltransferase activity by bovine colostrum N-acetylglucosaminyltransferase I
Biochim. Biophys. Acta
831
192-200
1985
Bos taurus
Manually annotated by BRENDA team
Nishikawa, Y.; Pegg, W.; Paulsen, H.; Schachter, H.
Control of glycoprotein synthesis. Purification and characterization of rabbit liver UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I
J. Biol. Chem.
263
8270-8281
1988
Oryctolagus cuniculus
Manually annotated by BRENDA team
Tang, B.L.; Wong, S.H.; Low, S.H.; Hong, W.
The transmembrane domain of N-glucosaminyltransferase I contains a Golgi retention signal
J. Biol. Chem.
267
10122-10126
1992
Homo sapiens
Manually annotated by BRENDA team
Schachter, H.; Brockhausen, I.; Hull, E.
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis
Methods Enzymol.
179
351-397
1989
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Mesocricetus auratus, Sus scrofa
Manually annotated by BRENDA team
Fritz, T.A.; Gabb, M.M.; Wei, G.; Esko, J.D.
Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate
J. Biol. Chem.
269
28809-28814
1994
Cricetulus griseus
Manually annotated by BRENDA team
Nishiu, J.; Kioka, N.; Fukada, T.; Sakai, H.; Komano, T.
Characterization of rat N-acetylglucosaminyltransferase I expressed in Escherichia coli
Biosci. Biotechnol. Biochem.
59
1750-1752
1995
Rattus norvegicus
Manually annotated by BRENDA team
Reck, F.; Springer, M.; Meinjohanns, E.; Paulsen, H.; Brockhausen, I.; Schachter, H.
Synthetic substrate analogs for UDP-GlcNAc: manalpha1-3R beta1-2-N-acetylglucosaminyltransferase I. Substrate specificity and inhibitors for the enzyme
Glycoconj. J.
12
747-754
1995
Rattus norvegicus
Manually annotated by BRENDA team
Wagner, R.; Liedtke, S.; Kretzschmar, E.; Geyer, H.G.; Geyer, R.; Klenk, H.D.
Elongation of the N-glycans of fowl plague virus hemagglutinin expressed in Spodoptera frugiperda (Sf9) cells by coexpression of human beta1,2-N-acetylglucosaminyltransferase I
Glycobiology
6
165-175
1996
Homo sapiens
Manually annotated by BRENDA team
Yoshida, S.; Suzuki, M.; Yamano, S.; Takeuchi, M.; Ikenaga, H.; Kioka, N.; Sakai, H.; Komano, T.
Expression and characterization of rat UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I in Saccharomyces cerevisiae
Glycobiology
9
53-58
1999
no activity in Saccharomyces cerevisiae, Rattus norvegicus
Manually annotated by BRENDA team
Unligil, U.M.; Zhou, S.; Yuwaraj, S.; Sarkar, M.; Schachter, H.; Rini, J.M.
X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily
EMBO J.
19
5269-5280
2000
Oryctolagus cuniculus (P27115), Oryctolagus cuniculus
Manually annotated by BRENDA team
Opat, A.S.; Houghton, F.; Gleeson, P.A.
Medial Golgi but not late Golgi glycosyltransferases exist as high molecular weight complexes. Role of luminal domain in complex formation and localization
J. Biol. Chem.
275
11836-11845
2000
Homo sapiens
Manually annotated by BRENDA team
Wenderoth, I.; Von Schaewen, A.
Isolation and characterization of plant N-acetyl glucosaminyltransferase I (GntI) cDNA sequences. Functional analyses in the Arabidopsis cgl mutant and in antisense plants
Plant Physiol.
123
1097-1108
2000
Arabidopsis thaliana, Nicotiana tabacum, Solanum tuberosum (Q8VX56), Solanum tuberosum
Manually annotated by BRENDA team
Fujiyama, K.; Ido, Y.; Misaki, R.; Moran, D.G.; Yanagihara, I.; Honda, T.; Nishimura, S.I.; Yoshida, T.; Seki, T.
Human N-acetylglucosaminyltransferase I. Expression in Escherichia coli as a soluble enzyme, and application as an immobilized enzyme for the chemoenzymatic synthesis of N-linked oligosaccharides
J. Biosci. Bioeng.
92
569-574
2001
Homo sapiens
Manually annotated by BRENDA team
Chen, W.; Unligil, U.M.; Rini, J.M.; Stanley, P.
Independent Lec1A CHO glycosylation mutants arise from point mutations in N-acetylglucosaminyltransferase I that reduce affinity for both substrates. Molecular consequences based on the crystal structure of GlcNAc-TI
Biochemistry
40
8765-8772
2001
Mesocricetus auratus, Cricetulus griseus (P70680)
Manually annotated by BRENDA team
Mucha, J.; Svoboda, B.; Frohwein, U.; Strasser, R.; Mischinger, M.; Schwihla, H.; Altmann, F.; Hane, W.; Schachter, H.; Glossl, J.; Mach, L.
Tissues of the clawed frog Xenopus laevis contain two closely related forms of UDP-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I
Glycobiology
11
769-778
2001
Spodoptera frugiperda, Xenopus laevis
Manually annotated by BRENDA team
Zhang, W.; Cao, P.; Chen, S.; Spence, A.M.; Zhu, S.; Staudacher, E.; Schachter, H.
Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase
Biochem. J.
372
53-64
2003
Caenorhabditis elegans
Manually annotated by BRENDA team
Strasser, R.; Stadlmann, J.; Svoboda, B.; Altmann, F.; Glossl, J.; Mach, L.
Molecular basis of N-acetylglucosaminyltransferase I deficiency in Arabidopsis thaliana plants lacking complex N-glycans
Biochem. J.
387
385-391
2005
Arabidopsis thaliana, Oryctolagus cuniculus
Manually annotated by BRENDA team
Nozaki, H.; Matsuzawa, T.; Nakamura, T.; Arai, I.; Urashima, T.
Are there two forms of beta 2-N-acetylglucosaminyltransferase I in rat testicular and epididymal fluids?
Biochim. Biophys. Acta
1649
140-145
2003
Rattus norvegicus
Manually annotated by BRENDA team
Tvaroska, I.; Andre, I.; Carver, J.P.
Catalytic mechanism of the inverting N-acetylglucosaminyltransferase I: DFT quantum mechanical model of the reaction pathway and determination of the transition state structure
Glycobiology
13
559-566
2003
Oryctolagus cuniculus (P27115)
Manually annotated by BRENDA team
Strasser, R.; Altmann, F.; Glossl, J.; Steinkellner, H.
Unaltered complex N-glycan profiles in Nicotiana benthamiana despite drastic reduction of beta1,2-N-acetylglucosaminyltransferase I activity
Glycoconj. J.
21
275-282
2004
Nicotiana benthamiana
Manually annotated by BRENDA team
Nozaki, H.; Miyamoto, A.; Hayashi, K.G.; Matsui, M.; Yoshida, T.; Nakamura, T.; Arai, I.; Urashima, T.
N-Acetylglucosaminyltransferase I activity in bovine ovarian follicular fluids from dominant and atretic follicles
J. Appl. Glycosci.
51
315-320
2004
Bos taurus
-
Manually annotated by BRENDA team
Nozaki, H.; Wijayagunawardane, M.P.; Kodituwakku, S.P.; Yoshida, T.; Nakamura, T.; Arai, I.; Urashima, T.; Miyamoto, A.
N-acetylglucosaminyltransferase I activity of bovine oviduct epithelial cells: stimulation by luteinizing hormone, vascular endothelial growth factor and tumor necrosis factor alpha
J. Reprod. Dev.
51
229-234
2005
Bos taurus
Manually annotated by BRENDA team
Schachter, H.; Reck, F.; Paulsen, H.
Use of synthetic oligosaccharide substrate analogs to map the active sites of N-acetylglucosaminyltransferases I and II
Methods Enzymol.
363
459-475
2003
Rattus norvegicus
Manually annotated by BRENDA team
Matsunami, K.; Miyagawa, S.; Nakagawa, K.; Otsuka, H.; Hideaki, O.; Shirakura, R.
Molecular cloning of pigGnT-I and I.2: an application to xenotransplantation
Biochem. Biophys. Res. Commun.
343
677-683
2006
Sus scrofa
Manually annotated by BRENDA team
Kasajima, Y.; Yamaguchi, M.; Hirai, N.; Ohmachi, T.; Yoshida, T.
In vivo expression of UDP-N-acetylglucosamine: alpha-3-D-Mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT-1) in Aspergillus oryzae and effects on the sugar chain of alpha-amylase
Biosci. Biotechnol. Biochem.
70
2662-2668
2006
Rattus norvegicus
Manually annotated by BRENDA team
Kozmon, S.; Tvaroska, I.
Catalytic mechanism of glycosyltransferases: hybrid quantum mechanical/molecular mechanical study of the inverting N-acetylglucosaminyltransferase I
J. Am. Chem. Soc.
128
16921-16927
2006
Oryctolagus cuniculus (P27115)
Manually annotated by BRENDA team
Kainz, E.; Gallmetzer, A.; Hatzl, C.; Nett, J.H.; Li, H.; Schinko, T.; Pachlinger, R.; Berger, H.; Reyes-Dominguez, Y.; Bernreiter, A.; Gerngross, T.; Wildt, S.; Strauss, J.
N-glycan modification in Aspergillus species
Appl. Environ. Microbiol.
74
1076-1086
2008
Homo sapiens
Manually annotated by BRENDA team
Saribas, A.S.; Johnson, K.; Liu, L.; Bezila, D.; Hakes, D.
Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys121
Biochem. Biophys. Res. Commun.
362
381-386
2007
Homo sapiens
Manually annotated by BRENDA team
Kang, J.S.; Frank, J.; Kang, C.H.; Kajiura, H.; Vikram, M.; Ueda, A.; Kim, S.; Bahk, J.D.; Triplett, B.; Fujiyama, K.; Lee, S.Y.; von Schaewen, A.; Koiwa, H.
Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus
Proc. Natl. Acad. Sci. USA
105
5933-5938
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Sourrouille, C.; Marquet-Blouin, E.; DAoust, M.A.; Kiefer-Meyer, M.C.; Seveno, M.; Pagny-Salehabadi, S.; Bardor, M.; Durambur, G.; Lerouge, P.; Vezina, L.; Gomord, V.
Down-regulated expression of plant-specific glycoepitopes in alfalfa
Plant Biotechnol. J.
6
702-721
2008
Nicotiana tabacum
Manually annotated by BRENDA team
Chen, H.L.; Li, C.F.; Grigorian, A.; Tian, W.; Demetriou, M.
T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching
J. Biol. Chem.
284
32454-32461
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, R.; Pawlicki, M.; Hamilton, B.; Tolbert, T.
Enzyme-catalyzed synthesis of a hybrid N-linked oligosaccharide using N-acetylglucosaminyltransferase I
Adv. Synth. Catal.
350
1689-1695
2008
Homo sapiens
-
Manually annotated by BRENDA team
Schoberer, J.; Vavra, U.; Stadlmann, J.; Hawes, C.; Mach, L.; Steinkellner, H.; Strasser, R.
Arginine/lysine residues in the cytoplasmic tail promote ER export of plant glycosylation enzymes
Traffic
10
101-115
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Henquet, M.; Heinhuis, B.; Borst, J.; Eigenhuijsen, J.; Schreuder, M.; Bosch, D.; van der Krol, A.
Differential effects of human and plant N-acetylglucosaminyltransferase I (GnTI) in plants
Transgenic Res.
19
535-547
2009
Arabidopsis thaliana, Homo sapiens
Manually annotated by BRENDA team
Zhong, X.; Cooley, C.; Seth, N.; Juo, Z.S.; Presman, E.; Resendes, N.; Kumar, R.; Allen, M.; Mosyak, L.; Stahl, M.; Somers, W.; Kriz, R.
Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I
Biotechnol. Bioeng.
109
1723-1734
2012
Oryctolagus cuniculus
Manually annotated by BRENDA team
Schachter, H.; Boulianne, G.
Life is sweet! A novel role for N-glycans in Drosophila lifespan
Fly
5
18-24
2011
Drosophila melanogaster
Manually annotated by BRENDA team
Baiet, B.; Burel, C.; Saint-Jean, B.; Louvet, R.; Menu-Bouaouiche, L.; Kiefer-Meyer, M.C.; Mathieu-Rivet, E.; Lefebvre, T.; Castel, H.; Carlier, A.; Cadoret, J.P.; Lerouge, P.; Bardor, M.
N-glycans of Phaeodactylum tricornutum diatom and functional characterization of its N-acetylglucosaminyltransferase I enzyme
J. Biol. Chem.
286
6152-6164
2011
Phaeodactylum tricornutum
Manually annotated by BRENDA team
Dohi, K.; Isoyama-Tanaka, J.; Tokuda, T.; Fujiyama, K.
Recombinant expression and characterization of N-acetylglucosaminyltransferase I derived from Nicotiana tabacum
J. Biosci. Bioeng.
109
388-391
2010
Nicotiana tabacum (Q9ST97), Nicotiana tabacum
Manually annotated by BRENDA team
Schachter, H.
Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans
Semin. Cell Dev. Biol.
21
609-615
2010
Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
Manually annotated by BRENDA team
Abdel Rahman, A.; Ryczko, M.; Nakano, M.; Pawling, J.; Rodrigues, T.; Johswich, A.; Taniguchi, N.; Dennis, J.
Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism
Glycobiology
25
225-240
2015
Homo sapiens (P26572), Homo sapiens
Manually annotated by BRENDA team
Damerow, M.; Rodrigues, J.A.; Wu, D.; Guether, M.L.; Mehlert, A.; Ferguson, M.A.
Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei
J. Biol. Chem.
289
9328-9339
2014
Trypanosoma brucei brucei, Trypanosoma brucei brucei 427
Manually annotated by BRENDA team
Schoberer, J.; Liebminger, E.; Vavra, U.; Veit, C.; Castilho, A.; Dicker, M.; Maresch, D.; Altmann, F.; Hawes, C.; Botchway, S.; Strasser, R.
The transmembrane domain of N-acetylglucosaminyltransferase I is the key determinant for its Golgi subcompartmentation
Plant J.
80
809-822
2014
Nicotiana benthamiana
Manually annotated by BRENDA team
Yan, S.; Wang, H.; Schachter, H.; Jin, C.; Wilson, I.B.H.; Paschinger, K.
Ablation of N-acetylglucosaminyltransferases in Caenorhabditis induces expression of unusual intersected and bisected N-glycans
Biochim. Biophys. Acta
1862
2191-2203
2018
Caenorhabditis elegans (G5EBG7), Caenorhabditis elegans (G5EFK6), Caenorhabditis elegans (Q11068), Caenorhabditis elegans
Manually annotated by BRENDA team
Li, Y.; Liu, Y.; Zhu, H.; Chen, X.; Tian, M.; Wei, Y.; Gong, Y.; Jiang, J.
N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1
FEBS Lett.
594
358-366
2020
Homo sapiens (P26572)
Manually annotated by BRENDA team
Vanier, G.; Lucas, P.L.; Loutelier-Bourhis, C.; Vanier, J.; Plasson, C.; Walet-Balieu, M.L.; Tchi-Song, P.C.; Remy-Jouet, I.; Richard, V.; Bernard, S.; Driouich, A.; Afonso, C.; Lerouge, P.; Mathieu-Rivet, E.; Bardor, M.
Heterologous expression of the N-acetylglucosaminyltransferase I dictates a reinvestigation of the N-glycosylation pathway in Chlamydomonas reinhardtii
Sci. Rep.
7
10156
2017
Phaeodactylum tricornutum (G0WVT5), Phaeodactylum tricornutum, Arabidopsis thaliana (Q9XGM8)
Manually annotated by BRENDA team