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2.4.1.101: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.101

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
Man5GlcNAc2-[protein]
=
UDP
 +
Man5GlcNAc3-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-, alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, AtGnTI, beta-1-2 GlcNAc transferase, ChGnTI, EC 2.4.1.51, GlcNAc transferase I, GlcNAc-T I, GlcNAc-TI, GlcNAcT-I, gly-12, GLY-13, gly-14, GnT I, GnT-I, GnT1, GnTI, Golgi N-glycan branching N-acetylglucosaminyltransferase I, HuGnTI, MGAT1, N-acetylglucosaminyltransferase I, N-acetylglucosaminyltransferases I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, NT, pigGnT-I, PtGnTI, TbGnTI, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, UDP-GlcNac:alpha3-D-mannoside beta1,2-Nacetylglucosaminyltransferase I, UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I, UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine to alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2) beta-1,2-N-acetyl-D-glucosaminyltransferase, UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Disease

topprint

Disease on EC 2.4.1.101 - alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
(n-acetylneuraminyl)-galactosylglucosylceramide n-acetylgalactosaminyltransferase deficiency
Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.
alpha-1,3-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase deficiency
An Arabidopsis thaliana cDNA complements the N-acetylglucosaminyltransferase I deficiency of CHO Lec1 cells.
Molecular basis of N-acetylglucosaminyltransferase I deficiency in Arabidopsis thaliana plants lacking complex N-glycans.
Carcinoma
Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.
Carcinoma, Hepatocellular
Processing of asparagine-linked oligosaccharides in insect cells. N-acetylglucosaminyltransferase I and II activities in cultured lepidopteran cells.
Glioma
N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1.
Herpes Simplex
N-acetylgalactosaminyltransferase activity involved in O-glycosylation of herpes simplex virus type 1 glycoproteins.
Infections
Blocking cellular N-glycosylation suppresses human cytomegalovirus entry in human fibroblasts.
Engineering the baculovirus genome to produce galactosylated antibodies in lepidopteran cells.
Hybrid- and complex-type N-glycans are not essential for Newcastle disease virus infection and fusion of host cells.
Influenza virus entry and infection require host cell N-linked glycoprotein.
Infertility, Male
Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.
Influenza, Human
Influenza virus entry and infection require host cell N-linked glycoprotein.
Muscular Dystrophies
The role of the GlcNAc(beta)1,2Man(alpha)- moiety in mammalian development. Null mutations of the genes encoding UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2 cause embryonic lethality and congenital muscular dystrophy in mice and men, respectively.
Neoplasms
N-acetylglucosaminyltransferase I activity of bovine oviduct epithelial cells: stimulation by luteinizing hormone, vascular endothelial growth factor and tumor necrosis factor alpha.
N-acetylglucosaminyltransferase-I as a novel regulator of epithelial-mesenchymal transition.
Newcastle Disease
Hybrid- and complex-type N-glycans are not essential for Newcastle disease virus infection and fusion of host cells.
Pheochromocytoma
Comparison of the expression of cell surface poly-N-acetyllactosamine-type oligosaccharides in PC12 cells with those in its variant PC12D.
Teratocarcinoma
Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I.