2.3.1.65: bile acid-CoA:amino acid N-acyltransferase

This is an abbreviated version!
For detailed information about bile acid-CoA:amino acid N-acyltransferase, go to the full flat file.

Reaction

Synonyms

acyltransferase, glycine-taurine N-, amino acid N-choloyltransferase, BAAT, BAATP1, BACAT, BAT, bile acid CoA: amino acid N-acyltransferase, bile acid CoA:amino acid N-acyltransferase, bile acid CoA:N-acyltransferase, bile acid coenzyme A-amino acid N-acyltransferase, bile acid coenzyme A: amino acid N-acyltransferase, bile acid coenzyme A:amino acid N-acyltransferase, bile acid-CoA:amino acid N acyltransferase, bile acid-CoA:amino acid N-acyltransferase, bile acid�coenzyme A:amino acid N-acyltransferase, glycine-taurine N-acyltransferase, hBAT, mBAT, rBAT

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.65 bile acid-CoA:amino acid N-acyltransferase

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Results	in table
4	Activating Compound
7	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
2	Disease/ Diagnostics
1	Expression
1	General Information
5	General Stability
23	Inhibitors
1	Ki Value [mM]
36	KM Value [mM]
13	Localization
11	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
29	Organism
6	Pathway
6	pH Optimum
2	pH Range
2	pH Stability
13	Protein Variants
12	Purification (Commentary)
4	Reaction
1	Reaction Type
29	Reference
30	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
97	Substrates and Products (Substrate)
4	Subunits
46	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 2.3.1.65 - bile acid-CoA:amino acid N-acyltransferase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

BAAT-12AA Trunc

Homo sapiens

-

mutant enzyme BAAT-12AA Trunc with 12 removed carboxy-terminal amino acids (407-418)

757369

BAAT-Ex1Del

Homo sapiens

-

the amino (N)-terminal truncated mutant enzyme BAAT-Ex1Del possess no detectable N-acyltransferase activity

757369

BAAT-S

Homo sapiens

-

the mutant BAAT-S, lacking the final two amino acids, shows slightly reduced enzyme activity

757369

BAAT-SKL

Homo sapiens

-

mutant BAAT-SKL with a canonical PTS sequence has greater than a 2.5fold increase in N-acyltransferase activity compared with wild type enzyme using cholyl-CoA and taurine as substrates

757369

C235A

Homo sapiens

-

activity is less than 0.4% of the wild-type activity

659246

C235S

2 entries

C372A

Homo sapiens

-

mutant with low enzyme activity

487372

D326A

Homo sapiens

-

activity is less than 0.4% of the wild-type activity

659246

D328A

Homo sapiens

-

inactive enzyme

487372

H362A

Homo sapiens

-

inactive enzyme

487372

H362Q

Homo sapiens

-

activity is less than 0.4% of the wild-type activity

659246

additional information

Homo sapiens

-

the cytosolic enzyme localization is due to a carboxyterminal non-consensus peroxisomal targeting signal, SQL, since mutation of the SQL to SKL results in BAAT being efficiently imported into peroxisomes

702070

C235S

Homo sapiens

-

mutant with lower enzyme activity

487372

C235S

Homo sapiens

-

mutation converts the enzyme into an efficient bile acid-CoA thioesterase

659246