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2.3.1.65: bile acid-CoA:amino acid N-acyltransferase

This is an abbreviated version!
For detailed information about bile acid-CoA:amino acid N-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.65

Reaction

choloyl-CoA
+
glycine
=
CoA
+
glycocholate

Synonyms

acyltransferase, glycine-taurine N-, amino acid N-choloyltransferase, BAAT, BAATP1, BACAT, BAT, bile acid CoA: amino acid N-acyltransferase, bile acid CoA:amino acid N-acyltransferase, bile acid CoA:N-acyltransferase, bile acid coenzyme A-amino acid N-acyltransferase, bile acid coenzyme A: amino acid N-acyltransferase, bile acid coenzyme A:amino acid N-acyltransferase, bile acid-CoA:amino acid N acyltransferase, bile acid-CoA:amino acid N-acyltransferase, bile acid–coenzyme A:amino acid N-acyltransferase, glycine-taurine N-acyltransferase, hBAT, mBAT, rBAT

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.65 bile acid-CoA:amino acid N-acyltransferase

Inhibitors

Inhibitors on EC 2.3.1.65 - bile acid-CoA:amino acid N-acyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-hydroxynonenal
-
inactivated by 4HNE in a dose-dependent manner. The active-site His (His362) dose-dependently forms a 4-hydroxynonenal adduct, contributing to loss of activity
5,5'-dithiobis(2-nitrobenzoic acid)
chenodeoxycholate
-
-
cholate
cholesterol
-
-
Conjugated bile acids
-
efficient competitive inhibitors of cholyl-CoA binding
-
deoxycholate
-
-
glycocholate
glycodeoxycholate
-
-
N-ethylmaleimide
-
10 min, at 0.2 mM: 90% loss of activity, preincubation with cholyl-CoA before NEM-treatment protects
NaCl
-
above 50 mM
p-mercuribenzoate
-
reversible by dithioerythritol, substrates protect, serine and alanine protect
Pex5
-
-
-
taurocholate
taurodeoxycholate
-
-
ursodeoxycholate
-
-
additional information
-