2.3.1.56: aromatic-hydroxylamine O-acetyltransferase

This is an abbreviated version!
For detailed information about aromatic-hydroxylamine O-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyltransferase, aromatic hydroxylamine, aromatic hydroxylamine acetyltransferase, arylhydroxamate acyltransferase, arylhydroxamate N,O-acetyltransferase, arylhydroxamic acid acyltransferase, arylhydroxamic acid N,O-acetyltransferase, arylhydroxamic acyltransferase, More, N,O-acetyltransferase, N-hydroxy-2-acetylaminofluorene N-O acyltransferase, NAT

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.56 aromatic-hydroxylamine O-acetyltransferase

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Results	in table
1	Activating Compound
4	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
5	General Stability
17	Inhibitors
12	KM Value [mM]
16	Localization
8	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
31	Organism
1	Oxidation Stability
7	pH Optimum
2	pH Range
1	Posttranslational Modification
6	Protein Variants
7	Purification (Commentary)
11	Reaction
1	Reaction Type
29	Reference
60	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
43	Substrates and Products (Substrate)
7	Subunits
12	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]

Substrates Products

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Substrates Products on EC 2.3.1.56 - aromatic-hydroxylamine O-acetyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

7-acetyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene

7-acetyl-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene

Homo sapiens

-

-

487254

-

-

?

7-bromo-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene

7-bromo-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene

Homo sapiens

-

-

487254

-

-

?

7-ethoxy-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene

7-ethoxy-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene

Homo sapiens

-

-

487254

-

-

?

7-ethyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene

7-ethyl-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene

Homo sapiens

-

-

487254

-

-

?

acetyl-CoA + 4-aminoveratrole

CoA + N-acetyl-4-aminoveratrole

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

486163

-

486163

?

acetyl-CoA + 4-anisidine

CoA + N-acetyl-4-anisidine

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

486163

-

486163

?

acetyl-CoA + 4-iodoaniline

CoA + N-acetyl-4-iodoaniline

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

486163

-

486163

?

N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene

Homo sapiens

-

-

487254

-

-

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

10 entries

N-hydroxy-2-propylaminofluorene + ?

?

Rattus norvegicus

-

i.e. N-hydroxy-N2-fluorenylpropionamide

487246

-

-

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

7 entries

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

8 entries

additional information

?

-

6 entries

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Canis lupus familiaris

-

-

487253

-

487253

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Homo sapiens

-

-

487250

-

487250

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Homo sapiens

-

-

487253

-

487253

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Homo sapiens

-

-

486162

-

486162

r

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Mesocricetus auratus

-

-

487242, 487250

-

-

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

-

487242, 487243, 487246

-

-

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

-

487250

-

487250

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

-

487253

-

487253

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

i.e. N-hydroxy-N2-fluorenylacetamide, not mammary gland enzyme

487241

-

-

?

N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl

N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl

Rattus norvegicus Sprague-Dawley CD

-

-

487243

-

-

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Mesocricetus auratus

-

-

487242

-

487242

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Mesocricetus auratus

-

-

487244

-

-

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Mesocricetus auratus

P50292, P50293

-

487252

-

487252

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Rattus norvegicus

-

-

487241

-

487241

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Rattus norvegicus

-

-

487242

-

487242

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Rattus norvegicus

-

-

487246

-

-

?

N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene

Rattus norvegicus

P50297, P50298

-

487252

-

487252

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Homo sapiens

-

-

486162

-

486162

r

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Mesocricetus auratus

-

S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl

487133

-

487133

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Oryctolagus cuniculus

-

S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl

487133

-

487133

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl

487133

-

487133

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl

487241

-

487241

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines

487241

-

-

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

noninducible, no known natural substrate in rat

487243

-

-

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus Sprague-Dawley CD

-

noninducible, no known natural substrate in rat

487243

-

-

?

additional information

?

-

Canis lupus familiaris

-

important for the activation of urinary metabolites of carcinogenic arylamines for the initiation of bladder carcinogenesis in the dog

487253

-

-

?

additional information

?

-

Homo sapiens

-

-

487253

-

-

?

additional information

?

-

Homo sapiens

-

7-substituted-N-hydroxy-2-acetylamino fluorenes form adducts with DNA, which is inhibited by addition of ascorbic acid, 4-(2-biphenyl)-2-hydroxytetronic acid, and partly by N-tert-butyl-alpha-phenylnitrone, triethylphosphite, potassium O-ethylxanthate, thiourea, and N-acetylmethionine, not in case of 7-acetyl-N-hydroxy-2-acetylamino fluorene

487254

-

-

?

additional information

?

-

Homo sapiens

-

metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts

487251

-

-

?

additional information

?

-

Mesocricetus auratus

-

acetohydroxamic acids with the N-atom of the hydroxamic acid group attached directly to aliphatic or cycloalkyl groups are no substrates or inhibitors

487245

-

-

?

additional information

?

-

Rattus norvegicus

-

acetohydroxamic acids with the N-atom of the hydroxamic acid group attached directly to aliphatic or cycloalkyl groups are no substrates or inhibitors

487245

-

-

?