2.3.1.56: aromatic-hydroxylamine O-acetyltransferase

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For detailed information about aromatic-hydroxylamine O-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyltransferase, aromatic hydroxylamine, aromatic hydroxylamine acetyltransferase, arylhydroxamate acyltransferase, arylhydroxamate N,O-acetyltransferase, arylhydroxamic acid acyltransferase, arylhydroxamic acid N,O-acetyltransferase, arylhydroxamic acyltransferase, More, N,O-acetyltransferase, N-hydroxy-2-acetylaminofluorene N-O acyltransferase, NAT

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.56 aromatic-hydroxylamine O-acetyltransferase

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Results	in table
1	Activating Compound
4	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
5	General Stability
17	Inhibitors
12	KM Value [mM]
16	Localization
8	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
31	Organism
1	Oxidation Stability
7	pH Optimum
2	pH Range
1	Posttranslational Modification
6	Protein Variants
7	Purification (Commentary)
11	Reaction
1	Reaction Type
29	Reference
60	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
43	Substrates and Products (Substrate)
7	Subunits
12	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.56 - aromatic-hydroxylamine O-acetyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

3 entries

additional information

?

-

3 entries

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines

487241

-

-

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus

-

noninducible, no known natural substrate in rat

487243

-

-

?

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl

N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Rattus norvegicus Sprague-Dawley CD

-

noninducible, no known natural substrate in rat

487243

-

-

?

additional information

?

-

Canis lupus familiaris

-

important for the activation of urinary metabolites of carcinogenic arylamines for the initiation of bladder carcinogenesis in the dog

487253

-

-

?

additional information

?

-

Homo sapiens

-

-

487253

-

-

?

additional information

?

-

Homo sapiens

-

metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts

487251

-

-

?