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Literature summary for 2.3.1.56 extracted from

  • Hein, D.; Doll, M.; Rustan, T.; Ferguson, R.
    Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions (1995), Cancer Res., 55, 3531-3536.
    View publication on PubMed
Search for more literature for 2.3.1.56

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutants in Escherichia coli strains DH5alpha and JM105 Homo sapiens

Protein Variants

Protein Variants Comment Organism
G286E small reduction in activity Homo sapiens
I114T strong reduction of the acetylation activity Homo sapiens
K268R slightly increased activity Homo sapiens
additional information nucleic acid substitutions C282T and C481T have no effect on activity Homo sapiens
R197Q moderate reduction of acetylation activity Homo sapiens
R64Q moderate reduction of acetylation activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 N-, O-, and N,O-acetyltransferase activity, wild-type and mutants Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl
-
 Homo sapiens N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
 r
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl
-
 Homo sapiens N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens