2.1.2.10: aminomethyltransferase

This is an abbreviated version!
For detailed information about aminomethyltransferase, go to the full flat file.

Reaction

Synonyms

aminomethyltransferase, Amt, GCVT, glycine decarboxylase complex, glycine synthase, synthase, glycine, T protein, T-protein, T-protein component of glycine cleavage complex, tetrahydrofolate aminomethyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.10 aminomethyltransferase

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Results	in table
36512	AA Sequence
3	Application
1	CAS Registry Number
8	Cloned(Commentary)
10	Cofactor
5	Crystallization (Commentary)
20	Disease/ Diagnostics
5	Expression
10	General Information
1	General Stability
2	Inhibitors
21	KM Value [mM]
16	Localization
1	Metals/Ions
8	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
108	Organism
6	Pathway
32	PDB ID
2	pH Optimum
38	Protein Variants
5	Purification (Commentary)
5	Reaction
2	Reaction Type
26	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
30	Substrates and Products (Substrate)
12	Subunits
21	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

Disease

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Disease on EC 2.1.2.10 - aminomethyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Hyperglycinemia, Nonketotic

Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System.

33569080

Hyperglycinemia, Nonketotic

Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia.

1634607

Hyperglycinemia, Nonketotic

Identification of the first reported splice site mutation (IVS7-1G-->A) in the aminomethyltransferase (T-protein) gene (AMT) of the glycine cleavage complex in 3 unrelated families with nonketotic hyperglycinemia.

11139253

Hyperglycinemia, Nonketotic

Identification of Two Novel Mutations in Aminomethyltransferase Gene in Cases of Glycine Encephalopathy.

30105116

Hyperglycinemia, Nonketotic

Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy.

25231368

Leukemia

Genomic organization of the dog dystroglycan gene DAG1 locus on chromosome 20q15.1-q15.2.

10720570

Leukemia, T-Cell

Genomic structures and sequences of two closely linked genes (AMT, TCTA) on dog chromosome 20q15.1-->q15.2.

10894947

Neoplasms

Proteomic analysis of the effect of retinoic acids on the human breast cancer cell line MCF-7.

24615502

Obesity

Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats.

33057941

Propionic Acidemia

Inhibition of glycine synthase by branched-chain alpha-keto acids. A possible mechanism for abnormal glycine metabolism in ketotic hyperglycinemia.

708054

Vitamin B 12 Deficiency

The vitamin B12-deficient rat as a possible model of ketotic hyperglycinemia.

1187241

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