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2.1.2.10: aminomethyltransferase

This is an abbreviated version!
For detailed information about aminomethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.10

Reaction

[protein]-S8-aminomethyldihydrolipoyllysine
+
tetrahydrofolate
=
[protein]-dihydrolipoyllysine
+
5,10-methylenetetrahydrofolate
+
NH3

Synonyms

aminomethyltransferase, Amt, GCVT, glycine decarboxylase complex, glycine synthase, synthase, glycine, T protein, T-protein, T-protein component of glycine cleavage complex, tetrahydrofolate aminomethyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.10 aminomethyltransferase

Substrates Products

Substrates Products on EC 2.1.2.10 - aminomethyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
reduced H-protein + 5,10-methylene-tetrahydrofolate + NH4Cl
?
show the reaction diagram
-
-
-
-
?
reduced H-protein + 5,10-methylenetetrahydropteroyltetraglutamate + NH4Cl
?
show the reaction diagram
-
-
-
-
?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
show the reaction diagram
S-aminomethyldihydrolipoylprotein + tetrahydropteroyltetraglutamate
dihydrolipoylprotein + 5,10-methylenetetrahydropteroyltetraglutamate + NH3
show the reaction diagram
-
-
better substrate than 5,10-methylenetetrahydrofolate, 6.5fold higher affinity for 5,10-methylenetetrahydropteroyltetraglutamate than for 5,10-methylenetetrahydrofolate
?
[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate
[protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3
show the reaction diagram
additional information
?
-