2.1.2.10: aminomethyltransferase
This is an abbreviated version!
For detailed information about aminomethyltransferase, go to the full flat file.
Word Map on EC 2.1.2.10
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2.1.2.10
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hyperglycinemia
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nonketotic
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photorespiratory
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photorespiration
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one-carbon
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ketotic
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hydroxymethyltransferase
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lipoamide
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medicine
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h-protein
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dimethylglycine
- 2.1.2.10
- hyperglycinemia
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nonketotic
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photorespiratory
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photorespiration
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one-carbon
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ketotic
- hydroxymethyltransferase
- lipoamide
- medicine
- h-protein
- dimethylglycine
Reaction
Synonyms
aminomethyltransferase, Amt, GCVT, glycine decarboxylase complex, glycine synthase, synthase, glycine, T protein, T-protein, T-protein component of glycine cleavage complex, tetrahydrofolate aminomethyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.1.2.10 - aminomethyltransferase
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REACTION DIAGRAM
reduced H-protein + 5,10-methylenetetrahydropteroyltetraglutamate + NH4Cl
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
S-aminomethyldihydrolipoylprotein + tetrahydropteroyltetraglutamate
dihydrolipoylprotein + 5,10-methylenetetrahydropteroyltetraglutamate + NH3
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better substrate than 5,10-methylenetetrahydrofolate, 6.5fold higher affinity for 5,10-methylenetetrahydropteroyltetraglutamate than for 5,10-methylenetetrahydrofolate
?
[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate
[protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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aminomethyl intermediate bound to the lipoate cofactor of H-protein
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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T-protein catalyzes the tetrahydrofolate-dependent step of the glycine cleavage reaction
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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tetrahydrofolate-dependent enzyme
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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folate-binding site: Lys-78, Lys-81 and Lys-352 are involved in binding, Lys-352 may serve as the primary binding site to alpha-carboxyl group of the first glutamate residue nearest the p-aminobenzoic acid ring of 5,10-methylenetetrahydrofolate and 5,10-methylenetetrahydropteroyltetraglutamate, Lys-81 may play a key role to hold the second glutamate residue through binding to its alpha-carboxyl group, 6.5fold higher affinity for 5,10-methylenetetrahydropteroyltetraglutamate than for 5,10-methylenetetrahydrofolate
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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decarboxylated glycine moiety attached to H-protein + tetrahydrofolate as substrates
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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strictly dependent on tetrahydrofolate
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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part of the glycine cleavage system
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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requires tetrahydrofolate
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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part of the glycine cleavage system
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-
?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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important enzyme in glycine metabolism
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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T-protein catalyzes the tetrahydrofolate-dependent step of the glycine cleavage reaction
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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tetrahydrofolate-dependent enzyme
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?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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part of the glycine cleavage system
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-
?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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decarboxylated glycine moiety attached to H-protein + tetrahydrofolate as substrates
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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T-protein participates in the formation of the one carbon unit and ammonia or the reverse reaction
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r
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
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glycine metabolism
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-
?
[protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3
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?
[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate
[protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3
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r
[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate
[protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3
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?
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enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex
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additional information
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component of the glycine cleavage system, T-protein is associated with H-protein forming a complex which is composed of one molecule of each of them
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additional information
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enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex
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additional information
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enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex
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additional information
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enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex
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additional information
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enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex
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additional information
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enzyme is a component of the reversible glycine cleavage system which is composed of 4 protein components named as P-, H-, L- and T-protein
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