2.1.2.10: aminomethyltransferase
This is an abbreviated version!
For detailed information about aminomethyltransferase, go to the full flat file.
Word Map on EC 2.1.2.10
-
2.1.2.10
-
hyperglycinemia
-
nonketotic
-
photorespiratory
-
photorespiration
-
one-carbon
-
ketotic
-
hydroxymethyltransferase
-
lipoamide
-
medicine
-
h-protein
-
dimethylglycine
- 2.1.2.10
- hyperglycinemia
-
nonketotic
-
photorespiratory
-
photorespiration
-
one-carbon
-
ketotic
- hydroxymethyltransferase
- lipoamide
- medicine
- h-protein
- dimethylglycine
Reaction
Synonyms
aminomethyltransferase, Amt, GCVT, glycine decarboxylase complex, glycine synthase, synthase, glycine, T protein, T-protein, T-protein component of glycine cleavage complex, tetrahydrofolate aminomethyltransferase
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Reference on EC 2.1.2.10 - aminomethyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bourguignon, J.; Neuburger, M.; Douce, R.
Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase
Biochem. J.
255
169-178
1988
Pisum sativum
Motokawa, Y.; Kikuchi, G.
Glycine metabolism by rat liver mitochondria. Reconstruction of the reversible glycine cleavage system with partially purified protein components
Arch. Biochem. Biophys.
164
624-633
1974
Rattus norvegicus
Okamura-Ikeda, K.; Fujiwara, K.; Motokawa, Y.
Purification and characterization of chicken liver T-protein, a component of the glycine cleavage system
J. Biol. Chem.
257
135-139
1982
Gallus gallus
Toone, J.R.; Applegarth, D.A.; Coulter-Mackie, M.B.; James, E.R.
Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): A strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)
Mol. Genet. Metab.
72
322-325
2001
Homo sapiens
Backofen, B.; Leeb, T.
Genomic organization of the murine aminomethyltransferase gene (Amt)
DNA Seq.
13
179-183
2002
Homo sapiens, Mus musculus
Okamura-Ikeda, K.; Fujiwara, K.; Motokawa, Y.
Identification of the folate binding sites on the Escherichia coli T-protein of the glycine cleavage system
J. Biol. Chem.
274
17471-17477
1999
Escherichia coli
Lokanath, N.K.; Kuroishi, C.; Okazaki, N.; Kunishima, N.
Purification, crystallization and preliminary crystallographic analysis of the glycine-cleavage system component T-protein from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. D
60
1450-1452
2004
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Orun, O.; Koch, M.H.; Kan, B.; Svergun, D.I.; Petoukhov, M.V.; Sayers, Z.
Structural characterization of T-protein of the Escherichia coli glycine cleavage system by X-ray small angle scattering
Cell. Mol. Biol.
49
453-459
2003
Escherichia coli
-
Okamura-Ikeda, K.; Kameoka, N.; Fujiwara, K.; Motokawa, Y.
Probing the H-protein-induced conformational change and the function of the N-terminal region of Escherichia coli T-protein of the glycine cleavage system by limited proteolysis
J. Biol. Chem.
278
10067-10072
2003
Escherichia coli
Lee, H.H.; Kim do, J.; Ahn, H.J.; Ha, J.Y.; Suh, S.W.
Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia
J. Biol. Chem.
279
50514-50523
2004
Thermotoga maritima
Okamura-Ikeda, K.; Hosaka, H.; Yoshimura, M.; Yamashita, E.; Toma, S.; Nakagawa, A.; Fujiwara, K.; Motokawa, Y.; Taniguchi, H.
Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia
J. Mol. Biol.
351
1146-1159
2005
Homo sapiens (P48728)
Toone, J.R.; Applegarth, D.A.; Levy, H.L.; Coulter-Mackie, M.B.; Lee, G.
Molecular genetic and potential biochemical characteristics of patients with T-protein deficiency as a cause of glycine encephalopathy (NKH)
Mol. Genet. Metab.
79
272-280
2003
Homo sapiens
Lokanath, N.K.; Kuroishi, C.; Okazaki, N.; Kunishima, N.
Crystal structure of a component of glycine cleavage system: T-protein from Pyrococcus horikoshii OT3 at 1.5 A resolution
Proteins
58
769-773
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Mueller, M.; Papadopoulou, B.
Stage-specific expression of the glycine cleavage complex subunits in Leishmania infantum
Mol. Biochem. Parasitol.
170
17-27
2010
Leishmania infantum, Leishmania major
Kikuchi, G.; Motokawa, Y.; Yoshida, T.; Hiraga, K.
Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
84
246-263
2008
Escherichia coli, Homo sapiens, Pisum sativum
Okamura-Ikeda, K.; Hosaka, H.; Maita, N.; Fujiwara, K.; Yoshizawa, A.C.; Nakagawa, A.; Taniguchi, H.
Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism
J. Biol. Chem.
285
18684-18692
2010
Escherichia coli
Azize, N.A.; Ngah, W.Z.; Othman, Z.; Md Desa, N.; Chin, C.B.; Md Yunus, Z.; Mohan, A.; Hean, T.S.; Syed Zakaria, S.Z.; Lock-Hock, N.
Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy
J. Hum. Genet.
59
593-597
2014
Homo sapiens
Gencpinar, P.; Cavusoglu, D.; Oezbeyler, O.e.; Kaya, O.O.; Baydan, F.; Olgac Dundar, N.
Nonketotic hyperglycinemia novel mutation in the aminomethyl transferase gene. Case report
Arch. Argent. Pediatr.
114
e142-e146
2016
Homo sapiens
Timm, S.; Giese, J.; Engel, N.; Wittmiss, M.; Florian, A.; Fernie, A.R.; Bauwe, H.
T-protein is present in large excess over the other proteins of the glycine cleavage system in leaves of Arabidopsis
Planta
247
41-51
2018
Arabidopsis thaliana
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