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2.1.2.10: aminomethyltransferase

This is an abbreviated version!
For detailed information about aminomethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.10

Reaction

[protein]-S8-aminomethyldihydrolipoyllysine
+
tetrahydrofolate
=
[protein]-dihydrolipoyllysine
+
5,10-methylenetetrahydrofolate
+
NH3

Synonyms

aminomethyltransferase, Amt, GCVT, glycine decarboxylase complex, glycine synthase, synthase, glycine, T protein, T-protein, T-protein component of glycine cleavage complex, tetrahydrofolate aminomethyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.10 aminomethyltransferase

Cloned

Cloned on EC 2.1.2.10 - aminomethyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Amt gene is located on chromosome 3p21 and contains 9 exons spanning about 6 kb of genomic sequence
-
C-terminally His6-tagged T-protein wild-type and mutant enzymes expression in Escherichia coli strain BL21(DE3)pLysS
-
cloning and sequencing of the Amt gene with 9 closely spaced exons that are contained within about 5 kb of genomic DNA, encoding a protein of 403 amino acids, cis-acting promoter is likely to be very short, Amt gene may be localized on chromosome 9F
-
gene AMT, genotyping in 14 glycine encephalopathy patients from 13 families from Malaysia, six patients (43%) have biallelic mutations in the AMT gene
-
gene AMT, located on chromosome 3p21.3, DNA and amino acid sequence determination and analysis. The AMT gene is located on chromosome 3p21.3 and the GLYCTK gene on 3p21.1. The possibility of a microdeletion is considered given the homozygosity for a mutation in both genes in a non-consanguineous family, but a comparative microarray does not identify a copy number variation in any exon of either gene
transfection to Leishmania infantum and Leishmania major