2.1.2.10: aminomethyltransferase

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For detailed information about aminomethyltransferase, go to the full flat file.

Reaction

Synonyms

aminomethyltransferase, Amt, GCVT, glycine decarboxylase complex, glycine synthase, synthase, glycine, T protein, T-protein, T-protein component of glycine cleavage complex, tetrahydrofolate aminomethyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.10 aminomethyltransferase

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Results	in table
36512	AA Sequence
3	Application
1	CAS Registry Number
8	Cloned(Commentary)
10	Cofactor
5	Crystallization (Commentary)
20	Disease/ Diagnostics
5	Expression
10	General Information
1	General Stability
2	Inhibitors
21	KM Value [mM]
16	Localization
1	Metals/Ions
8	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
108	Organism
6	Pathway
32	PDB ID
2	pH Optimum
38	Protein Variants
5	Purification (Commentary)
5	Reaction
2	Reaction Type
26	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
30	Substrates and Products (Substrate)
12	Subunits
21	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.2.10 - aminomethyltransferase

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SYSTEMATIC NAME

IUBMB Comments

[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)

A component, with EC 1.4.4.2 glycine dehydrogenase (decarboxylating) and EC 1.8.1.4, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, formerly known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [3].