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1.13.11.4: gentisate 1,2-dioxygenase

This is an abbreviated version!
For detailed information about gentisate 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.4

Reaction

2,5-Dihydroxybenzoate
+
O2
=
maleylpyruvate

Synonyms

2,5-dihydroxybenzoate dioxygenase, DsmD, EC 1.13.1.4, EC 1.99.2.4, eGDO, GDO, GDO-II, gdoA, GDOsp, GenH, gentisate dioxygenase, gentisate oxygenase, gentisate-1,2-dioxygenase, gentisic acid oxidase, gtdA-2, hbzE, Nagl1, Nagl2, Nagl3, NarI, oxygenase, gentisate 1,2-di-, P25X gentisate 1,2-dioxygenase, P35X gentisate 1,2-dioxygenase, salicylate 1,2-dioxygenase, SDO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.4 gentisate 1,2-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.4 - gentisate 1,2-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-hydroxy 2 naphthoate
0.33 mM, 19% of wild type enzyme activity remaining
2,2'-dipyridyl
2,3-Dihydroxybenzoate
-
2,4-Dihydroxybenzoate
-
2,6-dihydroxybenzoate
-
3-hydroxybenzoate
-
-
4-Chlorocatechol
-
4-methylcatechol
-
5-chlorosalicylate
-
Ag+
-
1 mM, severely inhibited
Al3+
-
1 mM, moderately inhibited
Ca2+
-
5 mM, partial inhibition
Fe
2 mM, complete inactivation
Fe2+
-
1 mM, complete inactivation
H2O2
-
3 mM, 90% inactivation
homogentisate
-
Hydroxyquinol
-
iodoacetic acid
-
-
Li2SO4
5 mM 5-10% inhibition at pH 8.0
Mg2+
-
66% residual activity at 5 mM
MgSO4
5 mM, 5-10% inhibition at pH 8.0
Na+
-
5 mM, partial inhibition
Na2SO4
5 mM, 5-10% inhibition at pH 8.0
Ni2+
-
1 mM, moderately inhibited
o-phenanthroline
salicylate
Sodium arsenate
-
-
Thiosalicylate
-
-
Tiron
additional information
-