1.13.11.4: gentisate 1,2-dioxygenase
This is an abbreviated version!
For detailed information about gentisate 1,2-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.4
-
1.13.11.4
-
maleylpyruvate
-
protocatechuate
-
3-hydroxybenzoate
-
pseudaminobacter
-
salicylatoxidans
-
1-hydroxy-2-naphthoate
-
3,4-dioxygenase
-
monohydroxylated
-
fumarylpyruvate
-
isofunctional
-
5-hydroxylase
-
ring-fission
-
ring-cleaving
-
extradiol
-
bicupins
-
nocardioides
-
acidovorans
- 1.13.11.4
- maleylpyruvate
- protocatechuate
- 3-hydroxybenzoate
-
pseudaminobacter
- salicylatoxidans
- 1-hydroxy-2-naphthoate
-
3,4-dioxygenase
-
monohydroxylated
- fumarylpyruvate
-
isofunctional
-
5-hydroxylase
-
ring-fission
-
ring-cleaving
-
extradiol
-
bicupins
- nocardioides
- acidovorans
Reaction
Synonyms
2,5-dihydroxybenzoate dioxygenase, DsmD, EC 1.13.1.4, EC 1.99.2.4, eGDO, GDO, GDO-II, gdoA, GDOsp, GenH, gentisate dioxygenase, gentisate oxygenase, gentisate-1,2-dioxygenase, gentisic acid oxidase, gtdA-2, hbzE, Nagl1, Nagl2, Nagl3, NarI, oxygenase, gentisate 1,2-di-, P25X gentisate 1,2-dioxygenase, P35X gentisate 1,2-dioxygenase, salicylate 1,2-dioxygenase, SDO
ECTree
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Reference on EC 1.13.11.4 - gentisate 1,2-dioxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jones, D.C.N.; Cooper, R.A.
Catabolism of 3-hydroxybenzoate by the gentisate pathway in Klebsiella pneumoniae M5a1
Arch. Microbiol.
154
489-495
1990
Klebsiella pneumoniae
Sugiyama, S.; Yano, K.; Komagata, K.; Arima, K.
Metabolism of aromatic compounds by microbes: Part VII. Gentisic acid oxidase
Bull. Agric. Chem. Soc. Jpn
24
243-248
1960
Pseudomonas putida
-
Goetz, F.E.; Joo, J.
Gentisate dioxygenase activity in immobilized cell-free exracts prepared from salmonella typhimurium
Biotechnol. Tech.
4
113-116
1990
Salmonella enterica subsp. enterica serovar Typhimurium
-
Crawford, R.I.; Hutton, S.W.; Chapman, P.J.
Purification and properties of gentisate 1,2-dioxygenase from Moraxella osloensis
J. Bacteriol.
121
794-799
1975
Moraxella osloensis
Harpel, M.R.; Lipscomb, J.D.
Gentisate 1,2-dioxygenase from pseudomonas. Purification, characterization, and comparison of the enzymes from Pseudomonas testosteroni and Pseudomonas acidovorans
J. Biol. Chem.
265
6301-6311
1990
Comamonas testosteroni, Delftia acidovorans
Harpel, M.R.; Lipscomb, J.D.
Gentisate 1,2-dioxygenase from Pseudomonas. Substrate coordination to active site Fe2+ and mechanism of turnover
J. Biol. Chem.
265
22187-22196
1990
Delftia acidovorans, Comamonas testosteroni
Harpel, M.R.; Lipscomb, J.D.
Gentisate 1,2-dioxygenase from Pseudomonas acidovorans
Methods Enzymol.
188
101-107
1990
Delftia acidovorans
Wittich, R.M.; Wilkes, H.; Sinnwell, V.; Francke, W.; Fortnagel, P.
Metabolism of dibenzo-p-dioxin by Sphingomonas sp. strain RW1
Appl. Environ. Microbiol.
58
1005-1010
1992
Sphingomonas sp.
Suarez, M.; Ferrer, E.; Martin, M.
Purification and biochemical characterization of gentisate 1,2-dioxygenase from Klebsiella pneumoniae M5a1
FEMS Microbiol. Lett.
143
89-95
1996
Klebsiella pneumoniae
Chua, C.H.; Feng, Y.; Yeo, C.C.; Khoo, H.E.; Poh, C.L.
Identification of amino acid residues essential for catalytic activity of gentisate 1,2-dioxygenase from Pseudomonas alcaligenes NCIB 9867
FEMS Microbiol. Lett.
204
141-146
2001
Pseudomonas alcaligenes
Suemori, A.; Kurane, R.; Tomizuka, N.
Purification and properties of gentisate 1,2-dioxygenase from Rhodococcus erythropolis S-1
Biosci. Biotechnol. Biochem.
57
1781-1783
1993
Rhodococcus erythropolis
-
Fu, W.; Oriel, P.
Gentisate 1,2-dioxygenase from Haloferax sp. D1227
Extremophiles
2
439-446
1998
Haloferax sp.
Kiemer, P.; Tshisuaka, B.; Fetzner, S.; Lingens, F.
Degradation of benzoate via benzoyl-coenzyme A and gentisate by Bacillus stearothermophilus PK1, and purification of gentisate 1,2-dioxygenase
Biol. Fertil. Soils
23
307-313
1996
Geobacillus stearothermophilus, Geobacillus stearothermophilus PK1
Werwath, J.; Arfmann, H.A.; Pieper, D.H.; Timmis, K.N.; Wittich, R.M.
Biochemical and genetic characterization of a gentisate 1,2-dioxygenase from Sphingomonas sp. strain RW5
J. Bacteriol.
180
4171-4176
1998
Sphingomonas sp., Sphingomonas sp. RW5
Feng, Y.; Khoo, H.E.; Poh, C.L.
Purification and characterization of gentisate 1,2-dioxygenases from Pseudomonas alcaligenes NCIB 9867 and Pseudomonas putida NCIB 9869
Appl. Environ. Microbiol.
65
946-950
1999
Pseudomonas alcaligenes, Pseudomonas putida, Pseudomonas alcaligenes NCIB 9867, Pseudomonas putida NCIB 9869
Yeo, C.C.; Wong, M.V.; Feng, Y.; Song, K.P.; Poh, C.L.
Molecular characterization of an inducible gentisate 1,2-dioxygenase gene, xlnE, from Pseudomonas alcaligenes NCIMB 9867
Gene
312
239-248
2003
Pseudomonas alcaligenes, Pseudomonas alcaligenes P25X
Shen, X.H.; Jiang, C.Y.; Huang, Y.; Liu, Z.P.; Liu, S.J.
Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum
Appl. Environ. Microbiol.
71
3442-3452
2005
Corynebacterium glutamicum, Corynebacterium glutamicum RES167
Swetha, V.P.; Phale, P.S.
Metabolism of carbaryl via 1,2-dihydroxynaphthalene by soil isolates Pseudomonas sp. strains C4, C5, and C6
Appl. Environ. Microbiol.
71
5951-5956
2005
Pseudomonas sp.
Jeon, C.O.; Park, M.; Ro, H.S.; Park, W.; Madsen, E.L.
The naphthalene catabolic (nag) genes of Polaromonas naphthalenivorans CJ2: evolutionary implications for two gene clusters and novel regulatory control
Appl. Environ. Microbiol.
72
1086-1095
2006
Polaromonas naphthalenivorans (Q3S4B6), Polaromonas naphthalenivorans
Fairley, D.J.; Wang, G.; Rensing, C.; Pepper, I.L.; Larkin, M.J.
Expression of gentisate 1,2-dioxygenase (gdoA) genes involved in aromatic degradation in two haloarchaeal genera
Appl. Microbiol. Biotechnol.
73
691-695
2006
Haloferax sp., Haloarcula sp., Haloarcula sp. D1
Hirano, S.; Morikawa, M.; Takano, K.; Imanaka, T.; Kanaya, S.
Gentisate 1,2-dioxygenase from Xanthobacter polyaromaticivorans 127W
Biosci. Biotechnol. Biochem.
71
192-199
2007
Xanthobacter polyaromaticivorans (Q75W71), Xanthobacter polyaromaticivorans 127W (Q75W71), Xanthobacter polyaromaticivorans 127W
Tan, C.L.; Yeo, C.C.; Khoo, H.E.; Poh, C.L.
Replacement of tyrosine 181 by phenylalanine in gentisate 1,2-dioxygenase I from Pseudomonas alcaligenes NCIMB 9867 enhances catalytic activities
J. Bacteriol.
187
7543-7545
2005
Pseudomonas alcaligenes, Pseudomonas alcaligenes NCIMB 9867
Luo, S.; Liu, D.Q.; Liu, H.; Zhou, N.Y.
Site-directed mutagenesis of gentisate 1,2-dioxygenases from Klebsiella pneumoniae M5a1 and Ralstonia sp. strain U2
Microbiol. Res.
161
138-144
2006
Klebsiella pneumoniae, Ralstonia sp., Ralstonia sp. U2, Klebsiella pneumoniae M5a1
Adams, M.A.; Singh, V.K.; Keller, B.O.; Jia, Z.
Structural and biochemical characterization of gentisate 1,2-dioxygenase from Escherichia coli O157:H7
Mol. Microbiol.
61
1469-1484
2006
Escherichia coli (Q8X655), Escherichia coli
Liu, D.; Zhu, S.; Ni, J.
Purification and characterization of a gentisate 1,2-dioxygenase from Ralstonia solanacearum GMI 1000
Ann. Microbiol.
57
307-312
2007
Ralstonia solanacearum, Ralstonia solanacearum GMI 1000
-
Liu, D.; Zhu, T.; Fan, L.; Quan, J.; Guo, H.; Ni, J.
Identification of a novel gentisate 1,2-dioxygenase from Silicibacter pomeroyi
Biotechnol. Lett.
29
1529-1535
2007
Ruegeria pomeroyi (Q5LLB1), Ruegeria pomeroyi
Chen, J.; Li, W.; Wang, M.; Zhu, G.; Liu, D.; Sun, F.; Hao, N.; Li, X.; Rao, Z.; Zhang, X.C.
Crystal structure and mutagenic analysis of GDOsp, a gentisate 1,2-dioxygenase from Silicibacter pomeroyi
Protein Sci.
17
1362-1373
2008
Ruegeria pomeroyi (Q5LLB1), Ruegeria pomeroyi
Yeo, C.C.; Tan, C.L.; Gao, X.; Zhao, B.; Poh, C.L.
Characterization of hbzE-encoded gentisate 1,2-dioxygenase from Pseudomonas alcaligenes NCIMB 9867
Res. Microbiol.
158
608-616
2007
Pseudomonas alcaligenes, Pseudomonas alcaligenes P25X
Matera, I.; Ferraroni, M.; Bürger, S.; Stolz, A.; Briganti, F.
Preliminary crystallographic analysis of salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans
Acta Crystallogr. Sect. F
62
553-555
2006
Pseudaminobacter salicylatoxidans, Pseudaminobacter salicylatoxidans BN12
Hintner, J.P.; Lechner, C.; Riegert, U.; Kuhm, A.E.; Storm, T.; Reemtsma, T.; Stolz, A.
Direct ring fission of salicylate by a salicylate 1,2-dioxygenase activity from Pseudaminobacter salicylatoxidans
J. Bacteriol.
183
6936-6942
2001
Pseudaminobacter salicylatoxidans, Pseudaminobacter salicylatoxidans BN12
Hintner, J.P.; Reemtsma, T.; Stolz, A.
Biochemical and molecular characterization of a ring fission dioxygenase with the ability to oxidize (substituted) salicylate(s) from Pseudaminobacter salicylatoxidans
J. Biol. Chem.
279
37250-37260
2004
Pseudaminobacter salicylatoxidans, Pseudaminobacter salicylatoxidans BN12
Matera, I.; Ferraroni, M.; Bürger, S.; Scozzafava, A.; Stolz, A.; Briganti, F.
Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase
J. Mol. Biol.
380
856-868
2008
Pseudaminobacter salicylatoxidans, Pseudaminobacter salicylatoxidans BN12
Hirano, S.; Haruki, M.; Takano, K.; Imanaka, T.; Morikawa, M.; Kanaya, S.
Gene cloning and in vivo characterization of a dibenzothiophene dioxygenase from Xanthobacter polyaromaticivorans
Appl. Microbiol. Biotechnol.
69
672-681
2006
Xanthobacter polyaromaticivorans (Q75W71), Xanthobacter polyaromaticivorans nov.127W (Q75W71)
Di Gennaro, P.; Terreni, P.; Masi, G.; Botti, S.; De Ferra, F.; Bestetti, G.
Identification and characterization of genes involved in naphthalene degradation in Rhodococcus opacus R7
Appl. Microbiol. Biotechnol.
87
297-308
2010
Rhodococcus opacus (Q0PES5), Rhodococcus opacus, Rhodococcus opacus R7 (Q0PES5), Rhodococcus opacus R7
Liu, T.T.; Xu, Y.; Liu, H.; Luo, S.; Yin, Y.J.; Liu, S.J.; Zhou, N.Y.
Functional characterization of a gene cluster involved in gentisate catabolism in Rhodococcus sp. strain NCIMB 12038
Appl. Microbiol. Biotechnol.
90
671-678
2010
Rhodococcus sp. (E7CYQ0), Rhodococcus sp., Rhodococcus sp. NCIMB 12038 (E7CYQ0)
Ferraroni, M.; Matera, I.; Buerger, S.; Reichert, S.; Steimer, L.; Scozzafava, A.; Stolz, A.; Briganti, F.
The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate
FEBS J.
280
1643-1652
2013
Pseudaminobacter salicylatoxidans, Pseudaminobacter salicylatoxidans BN12
Lee, H.J.; Kim, J.M.; Lee, S.H.; Park, M.; Lee, K.; Madsen, E.L.; Jeon, C.O.
Gentisate 1,2-dioxygenase, in the third naphthalene catabolic gene cluster of Polaromonas naphthalenivorans CJ2, has a role in naphthalene degradation
Microbiology
157
2891-2903
2011
Polaromonas naphthalenivorans
Fu, W.; Oriel, P.
Degradation of 3-phenylpropionic acid by Haloferax sp. D1227
Extremophiles
3
45-53
1999
Haloferax sp. (Q330M9)
Eppinger, E.; Ferraroni, M.; Buerger, S.; Steimer, L.; Peng, G.; Briganti, F.; Stolz, A.
Function of different amino acid residues in the reaction mechanism of gentisate 1,2-dioxygenases deduced from the analysis of mutants of the salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans
Biochim. Biophys. Acta
1854
1425-1437
2015
Ruegeria pomeroyi
Adebusoye, S.A.
Biological degradation of 4-chlorobenzoic acid by a PCB-metabolizing bacterium through a pathway not involving (chloro)catechol
Biodegradation
28
37-51
2017
Cupriavidus sp. SK-3
Eppinger, E.; Stolz, A.
Expansion of the substrate range of the gentisate 1,2-dioxygenase from Corynebacterium glutamicum for the conversion of monohydroxylated benzoates
Protein Eng. Des. Sel.
30
57-65
2017
Corynebacterium glutamicum (Q8NLB9), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032 (Q8NLB9)
Huang, L.; Hu, H.; Tang, H.; Liu, Y.; Xu, P.; Shi, J.; Lin, K.; Luo, Q.; Cui, C.
Identification and characterization of a novel gentisate 1,2-dioxygenase gene from a halophilic Martelella strain
Sci. Rep.
5
14307
2015
Martelella sp. AD-3 (A0A127CMI7)
Hintner, J.P.; Reemtsma, T.; Stolz, A.
Biochemical and molecular characterization of a ring fission dioxygenase with the ability to oxidize (substituted) salicylate(s) from Pseudaminobacter salicylatoxidans
J. Biol. Chem.
279
37250-37260
2004
Pseudaminobacter salicylatoxidans (Q67FT0), Pseudaminobacter salicylatoxidans, Pseudaminobacter salicylatoxidans BN12 (Q67FT0)
Subbotina, N.M.; Chernykh, A.M.; Taranov, A.I.; Shebanova, A.D.; Moiseeva, O.V.; Ferraroni, M.; Kolomytseva, M.P.
Gentisate 1,2-dioxygenase from the gram-positive bacteria Rhodococcus opacus 1CP Identical active sites vs. different substrate selectivities
Biochimie
180
90-103
2021
Rhodococcus opacus (W5U174), Rhodococcus opacus 1CP (W5U174), Rhodococcus opacus 1CP
Li, N.; Peng, Q.; Yao, L.; He, Q.; Qiu, J.; Cao, H.; He, J.; Niu, Q.; Lu, Y.; Hui, F.
Roles of the gentisate 1,2-dioxygenases DsmD and GtdA in the catabolism of the herbicide Dicamba in Rhizorhabdus dicambivorans Ndbn-20
J. Agric. Food Chem.
68
9287-9298
2020
Rhizorhabdus dicambivorans, Rhizorhabdus dicambivorans Ndbn-20
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