EC Number   |
General Information |
Reference |
|---|
   3.1.3.86 | physiological function |
isoform SHIP1 inhibits haematopoietic cell proliferation, inhibits Akt signalling and regulates immune cell function in vitro and in vivo |
749866 |
| 3.1.3.86 | physiological function |
isoform SHIP2 functions as oncogene in colorectal cancer by regulating protein kinase B activation |
751770 |
| 3.1.3.86 | physiological function |
isoform SHIP2 regulates Akt signalling in metabolic tissues |
749866 |
| 3.1.3.86 | physiological function |
isoforms SHIP2 and SHIP1 have a different hierarchy of binding SH3-domain containing proteins |
714601 |
| 3.1.3.86 | physiological function |
overexpression of the wild-ype SHIP2 gene leads to a higher total lipid content (28%) compared to control, whereas overexpression of the dominant negative SHIP2 gene reduces total lipid content in oleate treated cells by 40%. Overexpression of SHIP2 wild-type also leads to a significant increase in both secretion of apoB100 containing lipoproteins and de novo lipogenesis. Overexpression of the SHIP2 dominant negative gene prevents oleate-induced de novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells |
749802 |
| 3.1.3.86 | physiological function |
PR130/Balpha1 and SHIP2 partially colocalize in untreated HeLa cells, and both translocate to the cell membrane on epidermal growth factor stimulation. Protein phosphatase 2A PR130/Balpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor-induced epidermal growth factor receptor degradation sustaining epidermal growth factor-mediated signaling |
714939 |
| 3.1.3.86 | physiological function |
SHIP is involved in platelet activation evoked by thrombin |
715430 |
| 3.1.3.86 | physiological function |
SHIP phosphatases serve as a brake that limit neutrophil motility and inflammation, at least in part through their effects on PI3K signaling |
732045 |
| 3.1.3.86 | physiological function |
SHIP2 interaction with vinexin alpha promotes the localization of SHIP2 at the periphery of the cells leaving its catalytic site intact. SHIP2 is active both as a PtdIns(3,4,5)P3 5-phosphatase and as a modulator of focal contact formation |
714946 |
| 3.1.3.86 | physiological function |
the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-1 is also implicated both as a haematopoietic tumour suppressor and activator |
751768 |
