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Literature summary for 3.1.3.86 extracted from

  • Dempke, W.C.M.; Uciechowski, P.; Fenchel, K.; Chevassut, T.
    Targeting SHP-1, 2 and SHIP pathways a novel strategy for cancer treatment? (2018), Oncology, 95, 257-269 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-alpha-aminocholestane selective inhibitor of isoform SHIP-1 Homo sapiens
AQX-1125 Rosiptor, inhibitor of isoform SHIP-1 Homo sapiens
NSC13480
-
Homo sapiens
NSC305787
-
Homo sapiens
sodium stibogluconate inhibitor of isoform SHIP-1 Homo sapiens
TNO155 inhibitor of isoform SHIP-2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Homo sapiens
-
1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens
-
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15357
-
-
Homo sapiens Q92835
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
Homo sapiens 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 142000, isoform SHIP-2, SDS-PAGE Homo sapiens
? x * 145000, isoform SHIP-1, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
INPP5D
-
Homo sapiens
INPPL1
-
Homo sapiens
SHIP-1 isoform Homo sapiens
SHIP-2 isoform Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to myeloproliferation and B-cell lymphoma in mice Homo sapiens
physiological function the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-1 is also implicated both as a haematopoietic tumour suppressor and activator Homo sapiens
physiological function the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-2 is a negative regulator of glucose homeostasis and is involved in the maturation and activation of mast cells as well as in phagocytosis directed by Fc receptors for immunoglobulin G, thus regulating allergic reactions and antibacterial defense Homo sapiens