Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol (3,4,5)-trisphosphate 5-phosphatase | - |
Homo sapiens |
SH2 domain-containing inositol polyphosphate 5-phosphatase 2 | - |
Homo sapiens |
SHIP2 | - |
Homo sapiens |
Src homology 2 domain-containing inositol polyphosphate 5-phosphatase 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PR130/Balpha1 and SHIP2 partially colocalize in untreated HeLa cells, and both translocate to the cell membrane on epidermal growth factor stimulation. Protein phosphatase 2A PR130/Balpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor-induced epidermal growth factor receptor degradation sustaining epidermal growth factor-mediated signaling | Homo sapiens |