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Literature summary for 3.1.3.86 extracted from

  • Zwaenepoel, K.; Goris, J.; Erneux, C.; Parker, P.J.; Janssens, V.
    Protein phosphatase 2A PR130/Balpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling (2010), FASEB J., 24, 538-547.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
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Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
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?

Synonyms

Synonyms Comment Organism
phosphatidylinositol (3,4,5)-trisphosphate 5-phosphatase
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Homo sapiens
SH2 domain-containing inositol polyphosphate 5-phosphatase 2
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Homo sapiens
SHIP2
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Homo sapiens
Src homology 2 domain-containing inositol polyphosphate 5-phosphatase 2
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Homo sapiens

General Information

General Information Comment Organism
physiological function PR130/Balpha1 and SHIP2 partially colocalize in untreated HeLa cells, and both translocate to the cell membrane on epidermal growth factor stimulation. Protein phosphatase 2A PR130/Balpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor-induced epidermal growth factor receptor degradation sustaining epidermal growth factor-mediated signaling Homo sapiens