Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
145000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | thrombin stimulation induces a tyrosine phosphorylation of SHIP | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PtdIns(3,4,5)-P3 phosphatase | - |
Homo sapiens |
SH2 domain-containing inositol 5-phosphatase | - |
Homo sapiens |
SHIP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme activity is not increased after thrombin stimulation of COS-7 cells | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | SHIP is involved in platelet activation evoked by thrombin | Homo sapiens |