Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
155000 | - |
isoform SHIP2, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | Homo sapiens | substrate of isoform SHIP1 in vitro | 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | Homo sapiens | substrate of isoforms SHIP2 and SHIP1 in vitro | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
additional information | Homo sapiens | SHIP2 does not hydrolyze 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate in vitro | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15357 | isoform SHIP2 | - |
Homo sapiens | Q92835 | isoform SHIP1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | isoforms SHIP2 and SHIP1 are constitutively tyrosine phosphorylated in chronic myelogenous leukemia progenitor cells | Homo sapiens |
phosphoprotein | isoforms SHIP2 and SHIP1 are constitutively tyrosine phosphorylated in chronic myelogenous leukemia progenitor cells. Stimulation of human hematopoietic growth factor responsive cell lines with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor leads to rapid tyrosine phosphorylation of SHIP2 and its resulting association with src homologous and collagen gene | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chronic myelogenous leukemia progenitor cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
M-07 cell | - |
Homo sapiens | - |
M-07 cell | subline R10- cell | Homo sapiens | - |
M-07 cell | subline R10+ cell | Homo sapiens | - |
RWLeu-4 cell | - |
Homo sapiens | - |
TF-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | substrate of isoform SHIP1 in vitro | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | substrate of isoforms SHIP2 and SHIP1 in vitro | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
additional information | SHIP2 does not hydrolyze 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate in vitro | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase | - |
Homo sapiens |
SHIP1 | isoform | Homo sapiens |
SHIP2 | isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | isoforms SHIP2 and SHIP1 have a different hierarchy of binding SH3-domain containing proteins | Homo sapiens |