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Literature summary for 3.1.3.86 extracted from

  • Wisniewski, D.; Strife, A.; Swendeman, S.; Erdjument-Bromage, H.; Geromanos, S.; Kavanaugh, W.M.; Tempst, P.; Clarkson, B.
    A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells (1999), Blood, 93, 2707-2720.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
155000
-
isoform SHIP2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Homo sapiens substrate of isoform SHIP1 in vitro 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens substrate of isoforms SHIP2 and SHIP1 in vitro 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
?
additional information Homo sapiens SHIP2 does not hydrolyze 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate in vitro ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15357 isoform SHIP2
-
Homo sapiens Q92835 isoform SHIP1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein isoforms SHIP2 and SHIP1 are constitutively tyrosine phosphorylated in chronic myelogenous leukemia progenitor cells Homo sapiens
phosphoprotein isoforms SHIP2 and SHIP1 are constitutively tyrosine phosphorylated in chronic myelogenous leukemia progenitor cells. Stimulation of human hematopoietic growth factor responsive cell lines with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor leads to rapid tyrosine phosphorylation of SHIP2 and its resulting association with src homologous and collagen gene Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
chronic myelogenous leukemia progenitor cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
K-562 cell
-
Homo sapiens
-
M-07 cell
-
Homo sapiens
-
M-07 cell subline R10- cell Homo sapiens
-
M-07 cell subline R10+ cell Homo sapiens
-
RWLeu-4 cell
-
Homo sapiens
-
TF-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O substrate of isoform SHIP1 in vitro Homo sapiens 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O substrate of isoforms SHIP2 and SHIP1 in vitro Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
?
additional information SHIP2 does not hydrolyze 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate in vitro Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
-
Homo sapiens
SHIP1 isoform Homo sapiens
SHIP2 isoform Homo sapiens

General Information

General Information Comment Organism
physiological function isoforms SHIP2 and SHIP1 have a different hierarchy of binding SH3-domain containing proteins Homo sapiens