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Version 2014-12-22
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Details for mitotic spindle assembly checkpoint MAD1-MAD2 complex
Gene ontology ID
GO:1990728
Definition
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex
Comment
An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
Synonyms
1. MAD1-MAD2 complex
References
1. GOC: bhm
2. PMID 12006501
3. PMID 22898774
4. IntAct: EBI-10691260
5. IntAct: EBI-10705307
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