Information on EC - carnosine synthase

for references in articles please use BRENDA:EC6.3.2.11
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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
       carnosine synthase
IUBMB Comments
This enzyme was thought to form AMP [1,2], but studies with highly purified enzyme proved that it forms ADP . Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates . It is also found in the skeletal muscle of some invertebrates. The enzyme can also catalyse the formation of homocarnosine from 4-aminobutanoate and L-histidine, with much lower activity .
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Word Map
  • dipeptide
  • olfactory
  • bulb
  • castration-resistant
  • high-intensity
  • histidine-containing
  • carnosine-related
The enzyme appears in viruses and cellular organisms
carnosine synthase, carnosine synthetase, carns, atpgd1, homocarnosine-carnosine synthetase, more
ATP + L-histidine + beta-alanine = ADP + phosphate + carnosine
show the reaction diagram
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