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Literature summary for 6.3.2.11 extracted from
- Carnosine-synthetase inhibition by beta-alanine analogues (1982), Life Sci., 30, 1763-1768.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Aminoethylphosphonic acid | weak | Gallus gallus |  |
| 2-Aminoethylphosphonic acid | weak | Rattus norvegicus | |
| 3-Aminopropane sulfonic acid | competitive with respect to beta-Ala | Gallus gallus | |
| 3-Aminopropane sulfonic acid | competitive with respect to beta-Ala | Rattus norvegicus | |
| 3-Aminopropanephosphonic acid | - |
Rattus norvegicus | |
| 5-Aminopentanoate | no inhibition | Gallus gallus | |
| 5-Aminopentanoate | - |
Rattus norvegicus | |
| Aminooxyacetate | - |
Rattus norvegicus | |
| Nipecotic acid | - |
Rattus norvegicus | |
| O-Phosphoethanolamine | weak | Gallus gallus | |
| O-Phosphoethanolamine | weak | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Gallus gallus | - |
| brain | - |
Rattus norvegicus | - |
| heart | - |
Gallus gallus | - |
| heart | - |
Rattus norvegicus | - |
| muscle | skeletal | Gallus gallus | - |
| muscle | skeletal | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-His + beta-Ala | - |
Gallus gallus | ADP + phosphate + carnosine | - |
? | |
| ATP + L-His + beta-Ala | - |
Rattus norvegicus | ADP + phosphate + carnosine | - |
? | |
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Release 2023.1 (January 2023)
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