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Literature summary for 6.3.2.11 extracted from
- Regional distribution of homocarnosine, homocarnosine-carnosine synthetase and homocarnosinase in human brain (1979), J. Neurochem., 32, 1629-1636.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.8 | - |
beta-Ala | - |
Homo sapiens | |
| 8.8 | - |
4-aminobutanoate | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | activates | Homo sapiens | |
| Mn2+ | activates | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | frontal and temporal cortex, activity decreases rapidly after brain death | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-His + 4-aminobutanoate | - |
Homo sapiens | AMP + phosphate + homocarnosine | - |
? | |
| ATP + L-His + beta-Ala | - |
Homo sapiens | ADP + phosphate + carnosine | - |
? | |
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