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Literature summary for 6.3.2.11 extracted from

  • Stenesh, J.J.; Winnick, T.
    Carnosine-anserine synthetase of muscle. 4. Partial purification of the enzyme and further studies of beta-alanyl peptide synthesis (1960), Biochem. J., 77, 575-581.
    View publication on PubMedView publication on EuropePMC
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General Stability

General Stability Organism
most of the activity is lost upon freezing or upon dialysis with EDTA-treated cellophan tubing for several h at 0°C Gallus gallus
pH 7.0, 25°C, 1 h, with crystalline ribonuclease, not significantly inactivated Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
diphosphate
-
 Gallus gallus
F-
-
 Gallus gallus
Fe2+ weak Gallus gallus
K+ 10-100 mM, weak inhibition Gallus gallus
Mo2+ weak Gallus gallus
Ni2+
-
 Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ maximal activity at 2 mM, inhibition at higher concentrations Gallus gallus
Mn2+ can substitute for Mg2+, more effective at low concentration Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
muscle pectoral Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-His + beta-Ala not r Gallus gallus ADP + phosphate + carnosine
-
 ?

pH Stability

pH Stability pH Stability Maximum Comment Organism
6 8 stable in the range Gallus gallus