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Information on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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IUBMB Comments
Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed . The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose . In rat, the enzyme is found predominantly in thymus and spleen.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate
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CDP-choline + H2O = CMP + phosphocholine
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