Ligand D-ribofuranose 5-phosphate

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Basic Ligand Information

Molecular Structure
Picture of D-ribofuranose 5-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11O8P
D-ribofuranose 5-phosphate
KTVPXOYAKDPRHY-SOOFDHNKSA-N
Synonyms:
5-O-phosphono-D-ribofuranose, D-ribose-5-phosphate, D-ribose-5-phosphoric acid, D-ribose 5-phosphate, Rib-5-phosphate, ribose-5 phosphate, ribose-5-P, ribose-5-phosphate, ribose 5'-phosphate, ribose 5-phosphate


Show all pahtways known for Show all BRENDA pathways known for D-ribofuranose 5-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxybutan-2-one + D-ribose 5-phosphate = acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
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ATP + D-ribose 5-phosphate = D-ribose 1,5-bisphosphate + ADP
show the reaction diagram
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ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
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D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
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ATP + ribose 5-phosphate + NH4+ = ?
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In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
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-
ATP + D-ribose = ADP + D-ribose 5-phosphate
show the reaction diagram
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-
phosphate + ADP-ribose = ADP + D-ribose 5-phosphate
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diphosphate + ADP-D-ribose = ATP + D-ribose 5-phosphate
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5'-inosinate + H2O = hypoxanthine + D-ribose 5-phosphate
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AMP + H2O = D-ribose 5-phosphate + adenine
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ADP-ribose + H2O = AMP + D-ribose 5-phosphate
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alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
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Substrate in Enzyme-catalyzed Reactions (87 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-ribose 5-phosphate + NADPH = D-ribitol 5-phosphate + NADP+
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D-ribose 5-phosphate + NADPH + H+ = ? + NADP+
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D-ribose 5-phosphate + NAD+ = ? + NADH
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pyruvate + D-ribose 5-phosphate = 1-deoxy-D-sedoheptulose 7-phosphate + CO2
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ATP + ribose 5-phosphate = ADP + ribose 1,5-bisphosphate
show the reaction diagram
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ATP + D-ribose 5-phosphate = D-ribose 1,5-bisphosphate + ADP
show the reaction diagram
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D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP
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D-glucose + D-ribose 5-phosphate = D-glucose 6-phosphate + D-ribose
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ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + H2O = D-ribose + phosphate
show the reaction diagram
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D-ribose 5-phosphate + phosphate = ?
show the reaction diagram
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D-ribose 5-phosphate = ?
show the reaction diagram
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D-ribose 5-phosphate = D-ribulose 5-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (53 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
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ATP + D-ribose = ADP + D-ribose 5-phosphate
show the reaction diagram
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ATP + D-ribose = ADP + D-ribose 5-phosphate
show the reaction diagram
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phosphate + ADP-ribose = ADP + D-ribose 5-phosphate
show the reaction diagram
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diphosphate + ADP-D-ribose = ATP + D-ribose 5-phosphate
show the reaction diagram
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D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate
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5'-inosinate + H2O = hypoxanthine + D-ribose 5-phosphate
show the reaction diagram
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ADP-Rib + H2O = AMP + Rib-5-phosphate
show the reaction diagram
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pseudouridine 5'-phosphate + H2O = uracil + D-ribose 5-phosphate
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D-ribulose 5-phosphate = D-ribose 5-phosphate
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Activator in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates interconversion of D to I form
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10 mM, activates
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11% increase of activity
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5 mM, activity of both isoenzymes is modestly enhanced
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Inhibitor in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
non-competitive
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above 15 mM
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10 mM, 20% inhibition
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inhibits the phosphorylation of D-ribose
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above 2 mM
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only isozyme PKp, not PKc
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9% residual activity at 5 mM
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14.2% inhibition at 10 mM
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poor inhibitor
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weak
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addition of 1.4 mM, inhibition 42.3%
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protection of inactivation by adenine
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competitive
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inhibition above 0.0125 M
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3D Structure of Enzyme-Ligand-Complex (PDB) (16 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (61 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4.1
-
wild-type, pH 7.2, 25°C
65
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37°C, pH6
1.84
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at pH 8.9 and 25°C
1.1
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pH 5.5, 37°C
10.2
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in 25 mM Tris-HCl, pH 8.0, and 0.1 mM MnCl2, 0.0005 mM glucose 1,6-bisphosphate,at 23°C

KM Value (181 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
29.1
-
-
2.2
-
wild-type, pH 7.2, 25°C
2.2
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pH 7.5, 50°C, concentration of ribose-5-phosphate between 0.5 and 15 mM
3
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pH 6.7, 85°C
1
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cosubstrate: ATP, pH 9.1, 37°C
1.31
-
-
1.2
-
-
0.534
-
37°C, pH6
24
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at pH 8.9 and 25°C
0.263
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in 25 mM Tris-HCl, pH 8.0, and 0.1 mM MnCl2, 0.0005 mM glucose 1,6-bisphosphate,at 23°C
1.8
-
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Ki Value (20 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.34
-
-
2.2
-
pH 7.5, 30°C

References & Links

Links to other databases for D-ribofuranose 5-phosphate

ChEBI
PubChem
ChEBI
PubChem