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Information on EC 2.7.7.84 - 2'-5' oligoadenylate synthase

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IUBMB Comments
The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
(2-5)A synthetase, 2',5'-An synthetase, 2',5'-OASE, 2',5'-oligoadenylate synthetase, 2',5'oligoadenylate synthetase, 2',5'oligoadenylate synthetase 1b, 2'-5' oligoadenylate synthetase, 2'-5'-oligoadenylate synthetase, 2'-5'OAS, 2'5' oligoadenylate synthetase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
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