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Literature summary for 2.7.7.84 extracted from

  • Suhadolnik, R.; Flick, M.; Mosca, J.; Sawada, Y.; Doetsch, P.; Vonderheid, E.
    2',5'oligoadenylate synthetase from cutaneous T-cell lymphoma: biosynthesis, identification, quantitation, molecular size of the 2',5'oligoadenylates, and inhibition of protein synthesis (1983), Biochemistry, 22, 4153-4158.
    View publication on PubMed
Search for more literature for 2.7.7.84

Protein Variants

Protein Variants Comment Organism
up induction by interferon Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens whereas only two 2',5'-adenylates that inhibit protein synthesis (i.e., trimer and tetramer) are synthesized by normal peripheral blood mononuclear cells, trimer, tetramer, pentamer, and hexamer are synthesized by peripheral blood mononuclear cells from cutaneous T-cell lymphomas ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoma cell cutaneous T-cell lymphoma Homo sapiens
-
mononuclear cell peripheral blood mononuclear cells from healthy persons, and obtained from cutaneous T-cell lymphomas Homo sapiens
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T-lymphocyte no appreciable difference in 2',5'-oligoadenylate synthetase activity is found between T-cells and non-T-cells from cutaneous T-cell lymphomas, increased activity of 2'5'-oligoadenylate synthetase in PBMC from cutaneous T-cell lymphomas forming tetramer, pentamer, and hexamer products Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information whereas only two 2',5'-adenylates that inhibit protein synthesis (i.e., trimer and tetramer) are synthesized by normal peripheral blood mononuclear cells, trimer, tetramer, pentamer, and hexamer are synthesized by peripheral blood mononuclear cells from cutaneous T-cell lymphomas Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
2',5'-An synthetase
-
 Homo sapiens
2',5'oligoadenylate synthetase
-
 Homo sapiens
ATP(2',5')-oligo(A) adenylyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function synthesis of higher molecular weight 2',5'-adenylates is that in vitro protein synthesis is inhibited 30% by a 2500fold dilution of the 2',5'-oligoadenylates synthesized by 2',5'-oligoadenylate synthetase in peripheral blood mononuclear cells cell-free extracts from cutaneous T-cell lymphoma, whereas a 2500fold dilution of the 2',5'-oligoadenylates from normal peripheral blood mononuclear cells is not inhibitory. No appreciable difference in 2',5'-oligoadenylate synthetase activity occurs between T-cells and non-T-cells from cutaneous T-cell lymphomas Homo sapiens