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Disease on EC 2.7.7.84 - 2'-5' oligoadenylate synthase

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DISEASE
TITLE OF PUBLICATION
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Acquired Immunodeficiency Syndrome
Downregulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome.
Elevated levels of interferon-induced 2'-5' oligoadenylate synthetase in generalized persistent lymphadenopathy and the acquired immunodeficiency syndrome.
Interferon-induced 2'-5' oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome.
Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression.
AIDS-Related Complex
Persistent elevation of 2-5A synthetase and prognosis in the AIDS-related complex (ARC).
Alzheimer Disease
Absence of the 40-kDa form of (2'-5')oligoadenylate synthetase and its corresponding mRNA from skin fibroblasts derived from Alzheimer disease patients.
mRNA levels and methylation patterns of the 2-5A synthetase gene in control and Alzheimer's disease (AD) fibroblasts.
Arthritis, Juvenile
Clinical value of measuring the interferon-induced enzyme 2'-5'-oligoadenylate synthetase in children.
Arthritis, Rheumatoid
2',5'-oligoadenylate synthetase induction in lymphocytes of patients with connective tissue diseases.
Asthma
Effect of oromucosal administration of IFN-alpha on allergic sensitization and the hypersensitive inflammatory response in animals sensitized to ragweed pollen.
Toll-like receptor 7 function is reduced in adolescents with asthma.
Autoimmune Diseases
Assay and the levels of 2-5A-synthetase in lymphocytes of patients with viral, bacterial and autoimmune diseases.
Bacterial Infections
(2'-5') Oligo A synthetase in human polymorphonuclear cells increased activity in interferon treatment and in viral infections.
Assay and the levels of 2-5A-synthetase in lymphocytes of patients with viral, bacterial and autoimmune diseases.
Clinical value of measuring the interferon-induced enzyme 2'-5'-oligoadenylate synthetase in children.
Differentiating between bacterial and viral infection by measuring both C-reactive protein and 2'-5'-oligoadenylate synthetase as inflammatory markers.
Enzyme markers for the presence of circulating interferon: 2-5A synthetase in blood lymphocytes and protein kinase in platelet-rich plasma.
Breast Neoplasms
Enhancement of natural killer cell activity and 2-5A synthetase in operable breast cancer patients treated with polyadenylic; polyuridylic acid.
Induction of 2'-5' oligoadenylate synthetase and activation of ribonuclease in tamoxifen treated human breast cancer cell lines.
Induction of 2'-5' oligoadenylate synthetase by 17 beta-oestradiol in a human breast cancer cell line.
Bronchitis, Chronic
Minimal dose of aerosolized interferon-alpha in human subjects: biological consequences and side-effects.
Burkitt Lymphoma
Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium butyrate in Burkitt's lymphoma cells.
Carcinogenesis
Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization.
Carcinoid Tumor
Interferon-induced enhancement of 2',5'-oligoadenylate synthetase in mid-gut carcinoid tumours.
Carcinoma
2-5A synthetase activity in patients with metastatic carcinoma and its response to interferon treatment.
Ampligen treatment of renal cell carcinoma: changes in 2-5A synthetase, 2-5A oligomer size and natural killer cell activity associated with antitumor response clinically.
Biologic and binding activities of IFN-alpha subtypes in ACHN human renal cell carcinoma cells and Daudi Burkitt's lymphoma cells.
Carcinoma, Embryonal
Interferon enhances 2-5A synthetase in embryonal carcinoma cells.
Carcinoma, Hepatocellular
Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8.
Hepatitis delta virus inhibits alpha interferon signaling.
Carcinoma, Renal Cell
Ampligen treatment of renal cell carcinoma: changes in 2-5A synthetase, 2-5A oligomer size and natural killer cell activity associated with antitumor response clinically.
Biologic and binding activities of IFN-alpha subtypes in ACHN human renal cell carcinoma cells and Daudi Burkitt's lymphoma cells.
Carcinoma, Squamous Cell
Growth regulation of A431 cells. Modulation of expression of transforming growth factor-alpha mRNA and 2',5'-oligoadenylate synthetase activity.
Central Nervous System Diseases
RNase L antiviral activity is not a critical component of the Oas1b-mediated flavivirus resistance phenotype.
Cervical Intraepithelial Neoplasia
Local expression of interferon-alpha and interferon receptors in cervical intraepithelial neoplasia.
Cholestasis
Effect of cholestasis and bile acids on interferon-induced 2',5'-adenylate synthetase and NK cell activities.
Classical Swine Fever
Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway.
Colonic Neoplasms
[Vasoactive intestinal peptide induces 2',5'-oligoadenylate synthetase and antiviral state in cells of HT-29 colonic cancer]
Communicable Diseases
Detection of elevated levels of 2-5A synthetase in serum from children with various infectious diseases.
Condylomata Acuminata
Topical Delivery of Interferon alpha in Human Volunteers and Treatment of Patients with Human Papillomavirus Infections.
Connective Tissue Diseases
2',5'-oligoadenylate synthetase induction in lymphocytes of patients with connective tissue diseases.
Dengue
Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study.
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
Long-term balancing selection at the west nile virus resistance gene, Oas1b, maintains transspecific polymorphisms in the house mouse.
Diabetes Mellitus, Type 1
2'-5' oligoadenylate synthetase and its relationship to HLA and genetic markers of insulin-dependent diabetes mellitus.
Association of IDDM and attenuated response of 2',5'-oligoadenylate synthetase to yellow fever vaccine.
OAS1 gene haplotype confers susceptibility to multiple sclerosis.
The antiviral 2',5'-oligoadenylate synthetase is persistently activated in type 1 diabetes.
Down Syndrome
Increased IFN-alpha-induced sensitivity but reduced reactivity of 2',5'-oligoadenylate synthetase (2,5AS) in trisomy 21 blood lymphocytes.
Encephalitis
Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis.
[Cerebrospinal fluid neopterin levels in children with neurologic diseases]
Encephalitis, Tick-Borne
Polymorphism of 2'-5'-oligoadenylate synthetase (OAS) genes, associated with predisposition to severe forms of tick-borne encephalitis, in human populations of North Eurasia.
Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus.
Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.
[Polymorphism in the human 2'-5'-oligoadenylate synthetase genes (OAS), associated with predisposition to severe forms of tick-borne encephalitis, in populations from North Eurasia].
Fatigue Syndrome, Chronic
2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.
Molecular signatures of peripheral blood mononuclear cells during chronic interferon-? treatment: relationship with depression and fatigue.
Serum concentrations of 2',5'-oligoadenylate synthetase, neopterin, and beta-glucan in patients with chronic fatigue syndrome and in patients with major depression.
Flavivirus Infections
Conserved Active-Site Residues Associated with OAS Enzyme Activity and Ubiquitin-Like Domains Are Not Required for the Antiviral Activity of goOASL Protein against Avian Tembusu Virus.
Functional analysis of duck, goose, and ostrich 2'-5'-oligoadenylate synthetase.
Long-term balancing selection at the west nile virus resistance gene, Oas1b, maintains transspecific polymorphisms in the house mouse.
Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.
The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells.
The role of mouse 2',5'-oligoadenylate synthetase 1 paralogs.
Glioblastoma
Constitutive expression of a 2',5'-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression.
Glioma
Growth inhibitory effects of interferon-beta but not interferon-alpha on human glioma cells: correlation of receptor binding, 2',5'-oligoadenylate synthetase and protein kinase activity.
Transcriptional induction of the p69 isoform of 2',5'-oligoadenylate synthetase by interferon-beta and interferon-gamma involves three regulatory elements and interferon-stimulated gene factor 3.
Glomerulonephritis
Clinical value of measuring the interferon-induced enzyme 2'-5'-oligoadenylate synthetase in children.
Hepatitis
2',5' Oligoadenylate synthetase activity in peripheral blood mononuclear cells and serum during interferon treatment of chronic non-A, non-B hepatitis.
Activities of 2'-5'oligoadenylate synthetase in peripheral blood mononuclear cells of patients with viral hepatitis, and chronic type B hepatitis during interferon therapy.
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Comparative study of clinical, histological, and immunological responses to interferon therapy in type non-A, non-B, and type B chronic hepatitis.
Effect of interferon treatment on serum 2',5'-oligoadenylate synthetase levels in hepatitis C-infected patients.
Elevation of 2',5'-oligoadenylate synthetase activity and HLA-I associated beta 2-microglobulin in response to recombinant interferon-gamma administration in chronic HBeAg-positive hepatitis.
Interferon-associated lymphocyte 2',5'-oligoadenylate synthetase in acute and chronic viral hepatitis.
Progress in the enzyme diagnosis of liver disease: reality or illusion?
Serum 2',5'-oligoadenylate synthetase concentrations in acute and chronic hepatitis C.
[2'-5' oligoadenylate synthetase activity in patients with acute viral hepatitis and chronic type B hepatitis, and its clinical significance]
Hepatitis A
Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
Strong transient expression of the type I interferon-induced MxA protein in hepatitis A but not in acute hepatitis B and C.
Hepatitis B
Changes in cytokine production during therapy with granulocyte-macrophage colony-stimulating factor in patients with chronic hepatitis B.
Clinical utility of 2',5'-oligoadenylate synthetase activity measurement: using whole blood as a highly sensitive method to detect the effects of IFN.
Effects of recombinant leukocyte interferon on ribonuclease activities in serum in chronic hepatitis B.
Elevated levels of 2',5'-oligoadenylate synthetase activity in peripheral blood mononuclear cells and serum during acute exacerbation of chronic hepatitis B.
Humoral and cellular immune abnormalities in adult hemophiliacs followed over a 2-year period.
Pilot study of recombinant human granulocyte-macrophage colony-stimulating factor in the treatment of chronic hepatitis B.
Relationship of the effects of interferon on chronic hepatitis B and the induction of 2',5'-oligoadenylate synthetase.
Serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis B.
Tumor necrosis factor-alpha and interferon-gamma inhibit synergistically viral replication in hepatitis B virus-replicating cells.
[Association of polymorphism of 2'-5' oligoadenylate synthetase 1 gene with the susceptibility of hepatitis B virus infection and IFN-alpha treatment response.]
Hepatitis B, Chronic
2',5'-Oligoadenylate synthetase activity in peripheral blood lymphocytes as a clinical marker in interferon therapy for chronic hepatitis B.
Changes in cytokine production during therapy with granulocyte-macrophage colony-stimulating factor in patients with chronic hepatitis B.
Changes in interferon receptors on peripheral blood mononuclear cells from patients with chronic hepatitis B being treated with interferon.
Effects of recombinant leukocyte interferon on ribonuclease activities in serum in chronic hepatitis B.
Elevated levels of 2',5'-oligoadenylate synthetase activity in peripheral blood mononuclear cells and serum during acute exacerbation of chronic hepatitis B.
Interferon-associated lymphocyte 2',5'-oligoadenylate synthetase in acute and chronic viral hepatitis.
Pharmacologic effect of recombinant human IFN-alpha, continuously released from a matrix prepared from a polyglycerol ester of fatty acids, on 2',5'-oligoadenylate synthetase activity in murine liver.
Relationship of HLA protein display to activation of 2-5A synthetase in HBe antigen or anti-HBe positive chronic HBV infection.
Relationship of the effects of interferon on chronic hepatitis B and the induction of 2',5'-oligoadenylate synthetase.
Serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis B.
Serum and urinary neopterin levels in patients with chronic active hepatitis B treated with interferon.
[2',5'-oligoadenylate synthetase activity in peripheral blood mononuclear cells obtained from patients with chronic hepatitis B during interferon therapy]
Hepatitis C
2',5' Oligoadenylate synthetase activity in peripheral blood mononuclear cells and serum during interferon treatment of chronic non-A, non-B hepatitis.
Activation of the interferon-inducible 2'-5'-oligoadenylate synthetase gene by hepatitis C virus core protein.
Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
Hepatitis C virus proteins exhibit conflicting effects on the interferon system in human hepatocyte cells.
Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.
Peginterferon alfa-2a does not alter the pharmacokinetics of methadone in patients with chronic hepatitis C undergoing methadone maintenance therapy.
Progress in the enzyme diagnosis of liver disease: reality or illusion?
Serum 2',5'-oligoadenylate synthetase concentrations in acute and chronic hepatitis C.
The Impact of Pegylated-Interferon ?-2b on Partial and Massive Hepatectomy Model in Rats.
The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.
Treatment of hepatitis C virus core-positive hepatocytes with the transfer of recombinant caspase-3 using the 2',5'-oligoadenylate synthetase gene promoter.
Hepatitis C, Chronic
2',5'-Oligoadenylate synthetase activity as a responsive marker during interferon therapy for chronic hepatitis C.
Activity of the interferon-induced 2',5'-oligoadenylate synthetase in patients with chronic hepatitis C.
Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C.
Effect of alpha interferon (IFN-alpha) on 2'-5' oligoadenylate synthetase activity in peripheral blood mononuclear cells of patients with chronic hepatitis C: relationship to the antiviral effect of IFN-alpha.
Effect of obesity on pharmacokinetics and biologic effect of interferon-alpha in hepatitis C.
Effects of therapy with interferon-alpha on peripheral blood lymphocyte subsets and NK activity in patients with chronic hepatitis C.
Establishment of a nonradioactive assay for 2'-5' oligoadenylate synthetase and its application in chronic hepatitis C patients receiving interferon-alpha
Factors influencing the response to interferon therapy in chronic hepatitis C. Studies on viral genotype and induction of 2',5'-oligoadenylate synthetase in the liver and peripheral blood cells.
In vivo interferon system assessed by 2'-5' oligoadenylate synthetase activity in chronic hepatitis C virus patients treated with pegylated interferon and ribavirin.
Ketoprofen, peginterferon 2a and ribavirin for genotype 1 chronic hepatitis C: a phase II study.
Serum 2',5'-oligoadenylate synthetase concentrations in acute and chronic hepatitis C.
[2-5 AS activity in serum and peripheral blood mononuclear cells for chronic active hepatitis C and the relationship to clinical outcome of interferon therapy]
[Changes of serum 2',5'-oligoadenylate synthetase activity and neopterin during interferon treatment for chronic hepatitis C]
Hepatitis, Chronic
2',5'-Oligoadenylate synthetase activity in the liver and peripheral blood mononuclear cells of chronic hepatitis patients.
Interferon-associated lymphocyte 2',5'-oligoadenylate synthetase in acute and chronic viral hepatitis.
Significance of 2',5'-oligoadenylate synthetase activity and HCV genotype in IFN therapy for type C chronic hepatitis.
Herpes Genitalis
The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection.
Herpes Simplex
2',5'-oligoadenylate synthetase in interferon-alpha- and acyclovir-treated herpes simplex virus-infected cells.
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
Induction of 2',5'-oligoadenylate synthetase and interferon in mouse trigeminal ganglia infected with herpes simplex virus.
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
The mechanism of poly I:C-induced antiviral activity in peritoneal macrophage.
Histiocytic Necrotizing Lymphadenitis
Alpha-interferon in Kikuchi's disease.
HIV Infections
Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression.
Immune System Diseases
Interferon and 2-5A synthetase in patients with immune diseases.
Infections
(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.
2',5' oligoadenylate synthetase activity in bovine peripheral blood mononuclear cells following bovine herpesvirus type-1-induced respiratory disease: a prognostic indicator?
2',5'-oligoadenylate synthetase in interferon-alpha- and acyclovir-treated herpes simplex virus-infected cells.
2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells.
2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion.
2-5A synthetase expression in mice infected with Trypanosoma cruzi.
A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.
Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice.
Comparison of the effects of rabies virus infection and of combined interferon and poly(I).poly(C) treatment on the levels of 2',5'-adenyladenosine oligonucleotides in different organs of mice.
Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection.
Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection.
Differentiating between bacterial and viral infection by measuring both C-reactive protein and 2'-5'-oligoadenylate synthetase as inflammatory markers.
Early immune response in healthy and immunocompromised subjects with primary varicella-zoster virus infection.
Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells.
Effect of age on the pathogenesis of DHV-1 in Pekin ducks and on the innate immune responses of ducks to infection.
Factors influencing the response to interferon therapy in chronic hepatitis C. Studies on viral genotype and induction of 2',5'-oligoadenylate synthetase in the liver and peripheral blood cells.
Functional characterization of murine cell lines expressing high, intermediate, or negative levels of surface receptors for interferon-gamma.
Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J.
Hepatitis C virus impairs TLR3 signaling and inhibits IFN-? 1 expression in human hepatoma cell line.
Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes.
Immunoregulation during acute infection with Epstein-Barr virus: dynamics of interferon and 2',5'-oligoadenylate synthetase activity.
Induction of 2',5'-oligoadenylate synthetase and interferon in mouse trigeminal ganglia infected with herpes simplex virus.
Induction of the 2-5A system by interferon and transmissible gastroenteritis virus.
Infection of mouse neurones by West Nile virus is modulated by the interferon-inducible 2'-5' oligoadenylate synthetase 1b protein.
Interferon production and immune response induction in apathogenic rabies virus-infected mice.
Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
Interferon-associated lymphocyte 2',5'-oligoadenylate synthetase in acute and chronic viral hepatitis.
Interferon-induced 2'-5' oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome.
Molecular cloning and functional characterization of porcine 2',5'-oligoadenylate synthetase 1b and its effect on infection with porcine reproductive and respiratory syndrome virus.
Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection.
New insights into the role of RNase L in innate immunity.
OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses.
Polymorphisms of interferon-inducible genes OAS associated with interferon-? treatment response in chronic HBV infection.
Presence of (2'-5')oligoadenylate synthetase in avian erythrocytes.
Relationship of HLA protein display to activation of 2-5A synthetase in HBe antigen or anti-HBe positive chronic HBV infection.
Reverse genetics reveals a role of the rotavirus VP3 phosphodiesterase activity in inhibiting RNase L signaling and contributing to intestinal viral replication in vivo.
Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma.
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Serum 2'-5'-oligoadenylate synthetase levels and clinical response to interferon-beta therapy in women with genital human papillomavirus infection.
The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection.
Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1.
Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis.
Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions.
Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells.
Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53.
Viral determinants in the NS3 helicase and 2K peptide that promote West Nile virus resistance to antiviral action of 2',5'-oligoadenylate synthetase 1b.
What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?
[Expression of host genes in influenza virus infected cells]
[Regulation of human fibrolastic 2',5'-oligoadenylate synthetase gene activity in cytomegalovirus infected fibroblast cells]
Infectious Mononucleosis
Epstein-Barr virus-infected B lymphoblastoid cell lines: dynamics of interferon and 2'5'-oligoadenylate synthetase activity.
Influenza in Birds
Identification of 2'-5'-Oligoadenylate Synthetase-Like Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus.
Influenza, Human
Effects of proxigermanium on interferon production and 2',5'-oligoadenylate synthetase activity in the lung of influenza virus-infected mice and in virus-infected human peripheral blood mononuclear cell cultures.
Expression of interferon alfa signaling components in human alcoholic liver disease.
Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J.
Interferon-induced 2-5A synthetase activity in human peripheral blood mononuclear cells after immunization with influenza virus and rubella virus vaccines.
Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections.
Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells.
Structure and Activities of the NS1 Influenza Protein and Progress in the Development of Small-Molecule Drugs.
What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?
[Interferon status and the activity of dsRNA-dependent enzymes in volunteers and influenza patients receiving human recombinant alpha 2-interferon (reaferon)]
Leprosy
STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.
Leukemia
2-5A synthetase activity does not increase in interferon-resistant Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites.
Activation of 2',5'-oligoadenylate synthetase activity on induction of HL-60 leukemia cell differentiation.
Cells resistant to interferon-beta respond to interferon-gamma via the Stat1-IRF-1 pathway.
Effect of mouse interferon alpha/beta on the expression of H-2 (class I) antigens and on the levels of 2'-5' oligoadenylate synthetase activity in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice.
Growth inhibitory effect of gene-cloned interferons on human myeloblast colonies.
Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase.
Immunological recovery and dose evaluation in IFN-alpha treatment of hairy cell leukemia: analysis of leukocyte differentiation antigens, NK and 2',5'-oligoadenylate synthetase activity.
Induction of intracellular and plasma 2',5'-oligoadenylate synthetase by pentostatin.
JAK-STAT signaling involved in phorbol 12-myristate 13-acetate- and dimethyl sulfoxide-induced 2'-5' oligoadenylate synthetase expression in human HL-60 leukemia cells.
Role of interferon and 2',5'-oligoadenylate synthetase in erythroid differentiation of Friend leukemia cells. Studies with interferon-sensitive and -resistant variants.
Subcellular distribution of 2',5'-oligoadenylate synthetase in differentiating Friend leukemia cells.
Leukemia, Erythroblastic, Acute
Initial characterization of a spontaneous interferon secreted during growth and differentiation of Friend erythroleukemia cells.
Posttranscriptional regulation of beta interferon expression in erythroid Friend cells treated with gamma interferon.
Leukemia, Hairy Cell
Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase.
Immunological recovery and dose evaluation in IFN-alpha treatment of hairy cell leukemia: analysis of leukocyte differentiation antigens, NK and 2',5'-oligoadenylate synthetase activity.
Induction of intracellular and plasma 2',5'-oligoadenylate synthetase by pentostatin.
Leukemia, Lymphocytic, Chronic, B-Cell
Alpha-interferon receptors in malignant B-cells from patients with chronic lymphocytic leukemia: relation to induction of 2'-5'-oligoadenylate synthetase and blast transformation.
Combined effects of interferon and 2'-deoxycoformycin on 2',5'-oligoadenylate synthetase and adenosine deaminase in hairy cell and chronic lymphocytic leukemia cells.
Combined effects of interferon and steroid hormones on 2',5'-oligoadenylate synthetase activity in chronic lymphocytic leukemia cells.
Induction of 2',5'-oligoadenylate synthetase and blast transformation in primary chronic lymphocytic leukemia cells following exposure to interferon in vitro.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A possible correlation between interferon-stimulated gene expression and cytogenetic responses in chronic myelogenous leukemia patients treated with alpha-interferon.
In vivo sensitivity and resistance of chronic myelogenous leukemia cells to alpha-interferon: correlation with receptor binding and induction of 2',5'-oligoadenylate synthetase.
Induction of 2'-5' oligoadenylate synthetase during interferon treatment of chronic myelogenous leukemia.
Leukemia, Myeloid
Ectopic expression of 2-5A synthetase in myeloid cells induces growth arrest and facilitates the appearance of a myeloid differentiation marker.
Induction and function of 2',5'-oligoadenylate synthetase in differentiation of mouse myeloid leukemia cells.
Interferon-alpha inducible 2'-5' oligoadenylate synthetase transcripts in lymphoid and myeloid leukemias.
Leukemia, Myeloid, Acute
Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.
Leukemia, T-Cell
Activation of the interferon-inducible enzymes, 2',5'-oligoadenylate synthetase and PKR by human T-cell leukemia virus type I Rex-response element.
Leukemia-Lymphoma, Adult T-Cell
Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity.
Liver Cirrhosis
Decrease of interferon-induced 2',5'-oligoadenylate synthetase activity in cirrhotic rat liver.
Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.
Liver Diseases
2'5' Oligoadenylate synthetase assay in human diseases. Its clinical value in viral liver diseases.
Progress in the enzyme diagnosis of liver disease: reality or illusion?
Lung Neoplasms
Human lung cancer nodules in organotypic culture: no evidence of correlation between the antiproliferative effects of interferons and the induction of 2',5'-oligoadenylate synthetase.
Lupus Erythematosus, Systemic
2',5'-oligoadenylate synthetase induction in lymphocytes of patients with connective tissue diseases.
Clinical value of measuring the interferon-induced enzyme 2'-5'-oligoadenylate synthetase in children.
Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon.
Lymphadenopathy
Elevated levels of interferon-induced 2'-5' oligoadenylate synthetase in generalized persistent lymphadenopathy and the acquired immunodeficiency syndrome.
The relationship between 2-5A synthetase levels and persistent lymphadenopathy in homosexual men with antibodies to HTLV-III.
Lymphoma
Formation of tubuloreticular inclusions in human lymphoma cells compared to the induction of 2'-5'-oligoadenylate synthetase by leucocyte interferon in dose-effect and kinetic studies.
Lymphoma, Non-Hodgkin
In vivo and in vitro induction of 2'-5' oligoadenylate synthetase by interferon-alpha in nodular non-Hodgkin's lymphoma and correlations with the clinical response.
Lymphoma, T-Cell, Cutaneous
2',5'-oligoadenylate synthetase from cutaneous T-cell lymphoma: biosynthesis, identification, quantitation, molecular size of the 2',5'-oligoadenylates, and inhibition of protein synthesis.
Increased 2',5'-oligoadenylate synthetase activity in blood mononuclear leukocytes from patients with advanced cutaneous T-cell lymphoma.
Massive Hepatic Necrosis
Changes in 2',5'-oligoadenylate synthetase activity in peripheral blood mononuclear cells from patients with fulminant hepatitis.
Measles
2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
Melanoma
Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection.
Dietary selenium supplementation enhances antiviral immunity in chickens challenged with low pathogenic avian influenza virus subtype H9N2.
Differential activity of the 30-kD and the 100-kD forms of 2'-5'An synthetase induced by recombinant human interferon-alpha and interferon-gamma.
Effect of age on the pathogenesis of DHV-1 in Pekin ducks and on the innate immune responses of ducks to infection.
Resistance of melanoma cell lines to interferons correlates with reduction of IFN-induced tyrosine phosphorylation. Induction of the anti-viral state by IFN is prevented by tyrosine kinase inhibitors.
Meningitis, Aseptic
2',5'-Oligoadenylate synthetase activity and T cell subset in the cerebrospinal fluid and peripheral blood of aseptic meningitis.
[2',5'-oligoadenylate synthetase activity in cerebrospinal fluid of the children with aseptic meningitis]
[Cerebrospinal fluid neopterin levels in children with neurologic diseases]
Meningitis, Bacterial
[Cerebrospinal fluid neopterin levels in children with neurologic diseases]
Meningitis, Viral
Interferon induction and granulocyte function in patients with viral meningitis.
Multiple Myeloma
2',5'-Oligoadenylate synthetase levels in patients with multiple myeloma receiving maintenance therapy with interferon alpha 2b do not correlate with clinical response.
Multiple Sclerosis
(2'-5') Oligo A synthetase in human polymorphonuclear cells increased activity in interferon treatment and in viral infections.
2'-5' oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model.
Interleukin 1 receptor antagonist and 2'-5'-oligoadenylate synthetase-like molecules as novel biomarkers for multiple sclerosis patients in Bahrain.
Mumps
2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
Poor induction of interferon-induced 2',5'-oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1 alpha.
Neoplasms
2',5'-oligoadenylate synthetase activity in human mammary tumors and its potential correlation with tumor growth or hormonal responsiveness.
2'-5' oligo-A-synthetase activity in bovine peripheral blood leukocytes and alveolar macrophages exposed to recombinant interferons and tumor necrosis factor-alpha.
2'-5' oligoadenylate synthetase and its relationship to HLA and genetic markers of insulin-dependent diabetes mellitus.
2'-5' oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model.
2-5A synthetase activity in patients with metastatic carcinoma and its response to interferon treatment.
Activation of 2',5'-oligoadenylate synthetase and B-2 microglobulin in cancer patients treated with partially pure gamma interferon: dependence of biological effect on administration route.
Antitumoral action of interferon and poly(A)poly(U) on HeLa xenografts in the nude mouse.
Determination of 2-5A synthetase and 2-5A phosphodiesterase in neuroblastoma cells by analytical capillary isotachophoresis: effects of cytokines and comparison with radioenzymatic methods.
Direct action of interferon and inducers of interferon on tumor cells in athymic nude mice.
Effect of mouse interferon alpha/beta on the expression of H-2 (class I) antigens and on the levels of 2'-5' oligoadenylate synthetase activity in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice.
Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer's Disease.
Effects of mouse interferon on human tumour xenografts in the nude mouse host.
Enhanced Antitumor Immune Response in 2'-5' Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy.
Evaluation of short-interfering RNAs treatment in experimental rabies due to wild-type virus.
Hematologic and immunologic evaluation of recombinant human interleukin-6 in patients with advanced malignant disease: evidence for monocyte activation.
Human interferon inhibits the growth of established human breast tumours in the nude mouse.
Immunological effects of levamisole in vitro.
In vivo and in vitro induction of 2'-5' oligoadenylate synthetase by interferon-alpha in nodular non-Hodgkin's lymphoma and correlations with the clinical response.
Induction of 2',5'-oligoadenylate synthetase in freshly separated malignant cells from solid tumors. Variability in the susceptibility of interferon.
Interferon-induced enhancement of 2',5'-oligoadenylate synthetase in mid-gut carcinoid tumours.
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota.
Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site.
Local expression of interferon-alpha and interferon receptors in cervical intraepithelial neoplasia.
Mechanism of synergistic action of all-trans- or 9-cis-retinoic acid and interferons in breast cancer cells.
Modulation of double-stranded RNA-mediated gene induction by interferon in human umbilical vein endothelial cells.
Pilot study of natural human interleukin-2 in patients with chronic hepatitis B. Immunomodulatory and antiviral effects.
Predominant contribution of IFN-beta expression to apoptosis induction in human uterine cervical fibroblast cells by influenza-virus infection.
Recombinant alpha 2B interferon (IFN) in the treatment of chronic hepatitis C disease in thalassaemia major (TM).
Response of L-1210 tumor in mice toward treatment with interferon or poly(I) X poly(C).
Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death.
Tumor necrosis factor-alpha and interferon-gamma inhibit synergistically viral replication in hepatitis B virus-replicating cells.
Neuroblastoma
Determination of 2-5A synthetase and 2-5A phosphodiesterase in neuroblastoma cells by analytical capillary isotachophoresis: effects of cytokines and comparison with radioenzymatic methods.
Enhancement by retinoic acid and dibutyryl cyclic adenosine 3':5'-monophosphate of the differentiation and gene expression of human neuroblastoma cells induced by interferon.
In vitro and in vivo effect of interleukin-2 on the 2',5'-oligoadenylate synthetase activity of peripheral mononuclear blood cells.
Newcastle Disease
Identification of 2'-5'-Oligoadenylate Synthetase-Like Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus.
Immunological cross-reactivity between large and small (2'-5')oligoadenylate synthetases from pig cells.
Obesity
Effect of obesity on pharmacokinetics and biologic effect of interferon-alpha in hepatitis C.
Identification of genes whose expression is altered by obesity throughout the arterial tree.
Papilloma
2',5'-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis.
Papillomavirus Infections
Serum 2'-5'-oligoadenylate synthetase levels and clinical response to interferon-beta therapy in women with genital human papillomavirus infection.
Pheochromocytoma
Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis.
Plague
Duck stimulator of interferon genes plays an important role in host anti-duck plague virus infection through an IFN-dependent signalling pathway.
Identification of 2'-5'-Oligoadenylate Synthetase-Like Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus.
Porcine Reproductive and Respiratory Syndrome
Molecular cloning and functional characterization of porcine 2',5'-oligoadenylate synthetase 1b and its effect on infection with porcine reproductive and respiratory syndrome virus.
Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection.
Premature Birth
[A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes].
Prostatic Neoplasms
2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer.
Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells.
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.
Rabies
Comparison of the effects of rabies virus infection and of combined interferon and poly(I).poly(C) treatment on the levels of 2',5'-adenyladenosine oligonucleotides in different organs of mice.
Respiratory Syncytial Virus Infections
2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells.
Rubella
2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine.
Interferon-induced 2-5A synthetase activity in human peripheral blood mononuclear cells after immunization with influenza virus and rubella virus vaccines.
Sarcoma
2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells.
Sarcoma, Kaposi
Interferon-induced 2'-5' oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome.
Severe Combined Immunodeficiency
In vitro hyporeactivity to alpha-interferon in children with severe combined immunodeficiency disease.
Stomatitis
Functional characterization of murine cell lines expressing high, intermediate, or negative levels of surface receptors for interferon-gamma.
Tuberculosis
2'-5'-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study.
2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion.
Uveitis
Clinical value of measuring the interferon-induced enzyme 2'-5'-oligoadenylate synthetase in children.
Vaccinia
Full activation of RNaseL in animal cells requires binding of 2-5A within ankyrin repeats 6 to 9 of this interferon-inducible enzyme.
Identification by electron microscopy of the maturation steps in vaccinia virus morphogenesis inhibited by the interferon-induced enzymes, protein kinase (PKR), 2-5A synthetase, and nitric oxide synthase (iNOS).
Nature and mode of action of vaccinia virus products that block activation of the interferon-mediated ppp(A2'p)nA-synthetase.
Regulation of MuIFN-alpha/beta and MuIFN-gamma-induced antiviral states: differential effects with different challenge viruses and lack of correlation with 2'5' oligoadenylate synthetase levels.
Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.
Vesicular Stomatitis
Biologic and binding activities of IFN-alpha subtypes in ACHN human renal cell carcinoma cells and Daudi Burkitt's lymphoma cells.
Effects of prednisone, aspirin, and acetaminophen on an in vivo biologic response to interferon in humans.
Expression of intracellular interferon-alpha confers antiviral properties in transfected bovine fetal fibroblasts and does not affect the full development of SCNT embryos.
Injection of mice with antibody to mouse interferon alpha/beta decreases the level of 2'-5' oligoadenylate synthetase in peritoneal macrophages.
Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections.
Loss of interferon alpha and interferon tau-induced antiviral protection in interferon regulatory factor-2 DNA-binding domain dominant negative mutants.
Modulation of alpha-interferon's antiviral and clinical effects by aspirin, acetaminophen, and prednisone in healthy volunteers.
Regulation of MuIFN-alpha/beta and MuIFN-gamma-induced antiviral states: differential effects with different challenge viruses and lack of correlation with 2'5' oligoadenylate synthetase levels.
Viremia
Interferon-induced 2'-5' oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome.
Virus Diseases
2',5' oligoadenylate synthetase activity in bovine peripheral blood mononuclear cells following bovine herpesvirus type-1-induced respiratory disease: a prognostic indicator?
2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells.
2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons.
2'-5' oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model.
2-5A synthetase activities in herpes virus infection and after interferon treatment.
A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons.
A human cellular noncoding RNA activates the antiviral protein 2'-5'-oligoadenylate synthetase 1.
A sensitive assay for the IFN-regulated 2-5A synthetase enzyme.
Activity of the interferon-induced 2',5'-oligoadenylate synthetase in patients with chronic hepatitis C.
Alpha-interferon in Kikuchi's disease.
Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study.
Basal and interferon-induced 2',5'-oligoadenylate synthetase activity in human placental trophoblast and trophoblast-derived malignant cell lines.
Basal and interferon-induced 2',5'-oligoadenylate synthetase in human monocytes, lymphocytes, and peritoneal macrophages.
Clinical usefulness of serum 2'-5'-oligoadenylate synthetase for early diagnosis of viral infections among febrile adult patients.
Clinical utility of 2',5'-oligoadenylate synthetase activity measurement: using whole blood as a highly sensitive method to detect the effects of IFN.
Contrasted patterns of variation and evolutionary convergence at the antiviral OAS1 gene in old world primates.
Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells.
Differentiating between bacterial and viral infection by measuring both C-reactive protein and 2'-5'-oligoadenylate synthetase as inflammatory markers.
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
Effect of oromucosal administration of IFN-alpha on allergic sensitization and the hypersensitive inflammatory response in animals sensitized to ragweed pollen.
Effects of prednisone, aspirin, and acetaminophen on an in vivo biologic response to interferon in humans.
Enhanced Antitumor Immune Response in 2'-5' Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy.
Essential role for either TRS1 or IRS1 in human cytomegalovirus replication.
Experimental infection of pregnant cows with noncytopathogenic bovine viral diarrhoea virus between days 26 and 50 postbreeding.
Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection.
Expression of intracellular interferon-alpha confers antiviral properties in transfected bovine fetal fibroblasts and does not affect the full development of SCNT embryos.
Functional analysis of duck, goose, and ostrich 2'-5'-oligoadenylate synthetase.
Hyaluronic acid-gold nanoparticle/interferon ? complex for targeted treatment of hepatitis C virus infection.
Inhibition by interleukin-4 of constitutive beta interferon synthesis in mouse macrophages.
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Interferon-alpha in malignant and viral diseases. A review.
Interferon-induced 2-5A synthetase activity in human peripheral blood mononuclear cells after immunization with influenza virus and rubella virus vaccines.
Ischemia-induced changes in 2'-5'-oligoadenylate synthethase mRNA levels in rat brain: comparison with changes produced by perturbations of endoplasmic reticulum calcium homeostasis in neuronal cell cultures.
Lack of systematic correlation between the interferon mediated antiviral state and the levels of 2-5A synthetase and protein kinase in three different types of murine cells.
Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection.
Modulation of alpha-interferon's antiviral and clinical effects by aspirin, acetaminophen, and prednisone in healthy volunteers.
Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection.
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.
Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections.
RNA regulation of the antiviral protein 2'-5'-oligoadenylate synthetase.
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
Target specific hyaluronic acid-interferon alpha conjugate for the treatment of hepatitis C virus infection.
The 2'-5'-oligoadenylate synthetase in the lowest metazoa: isolation, cloning, expression and functional activity in the sponge Lubomirskia baicalensis.
The Association of OASL and Type I Interferons in the Pathogenesis and Survival of Intracellular Replicating Bacterial Species.
Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain.
[2'-5' olygoadenylate synthetase activity in peripheral facial paralysis]
West Nile Fever
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile virus.
Yellow Fever
Association of IDDM and attenuated response of 2',5'-oligoadenylate synthetase to yellow fever vaccine.
Long-term balancing selection at the west nile virus resistance gene, Oas1b, maintains transspecific polymorphisms in the house mouse.
Lymphocytic 2',5'-oligoadenylate synthetase activity increases prior to the appearance of neutralizing antibodies and immunoglobulin M and immunoglobulin G antibodies after primary and secondary immunization with yellow fever vaccine.
Zika Virus Infection
Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b.