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Information on EC - 2-amino-4-deoxychorismate synthase

for references in articles please use BRENDA:EC2.6.1.86
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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
       2-amino-4-deoxychorismate synthase
IUBMB Comments
Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4].
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Word Map
The enzyme appears in viruses and cellular organisms
adic synthase, 2-amino-2-deoxyisochorismate (adic) synthase, more
(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine
show the reaction diagram
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