Ligand chorismic acid

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Basic Ligand Information

Molecular Structure
Picture of chorismic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H10O6
chorismic acid
WTFXTQVDAKGDEY-HTQZYQBOSA-N
Synonyms:
chorismate, Derivatives of chorismate
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for chorismic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
show the reaction diagram
-
chorismate + L-glutamine = (2S)-2-amino-4-deoxychorismate + L-glutamate
show the reaction diagram
-
chorismate = 4-hydroxybenzoate + pyruvate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxybenzoate + pyruvate + H2O = chorismate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chorismate + H2O = ?
show the reaction diagram
-
chorismate = 4-hydroxybenzoate + pyruvate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxybenzoate + pyruvate + H2O = chorismate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 50% activation at 0.002 mM
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (165 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
17.6
-
in deuterated potassium phosphate buffer (20 mM, pH 7.0), at 20C
1.2
-
pH 6.5
22.4
-
in deuterated potassium phosphate buffer (20 mM, pH 7.0), at 20C
1.27
-
pH and temperature not specified in the publication

KM Value (195 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
35
-
-
0.983
-
pH 6.5
0.162
-
pH and temperature not specified in the publication

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0028
-
30C, pH 7.6, in presence of 0.005 mM tyrosine

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1
-
IC50: 1 mM

References & Links

Links to other databases for chorismic acid

ChEBI
PubChem
ChEBI
PubChem