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Information on EC 2.1.1.296 - methyltransferase cap2

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.296 methyltransferase cap2
IUBMB Comments
The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency .
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Word Map
  • 2.1.1.296
  • c-mannosylation
  • mannose
  • neuroblast
  • thrombospondin
  • 2'-o-ribose
  • r-spondin1
  • methyltransferases
  • netrin
The enzyme appears in viruses and cellular organisms
Synonyms
hmtr2, cmtr2, ftsjd1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
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PATHWAY SOURCE
PATHWAYS
MetaCyc
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