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Results 1 - 3 of 3

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.1.1.296	more	a conventional 5'-terminal structure of eukaryotic mRNAs consists of a 7-methylguanosine (m7G) moiety linked to the first transcribed nucleotide by a 5' to 5' triphosphate bridge resulting in the structure m7GpppN, which is referred to as cap 0, and most often the first and second transcribed nucleotide carry 2'-O-methyl groups (cap 1 and cap 2 structures, respectively). The cap2 methyltransferase, EC 2.1.1.296 transfers the methyl group to the second nucleotide. In contrast, four nucleotides adjacent to the m7G cap are methylated at the SL RNA 5' end to generate a cap 4 structure: m7G-ppp-N6,N6,2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3,2'-O-methyluridine. The cap 4 structure seems to be restricted to the family Trypanosomatidae
2.1.1.296	more	hMTr2 protein transfers a methyl group from S-adenosylmethionine to the 2'-O-ribose of the second nucleotide of messenger RNA and small nuclear RNA
2.1.1.296	S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA]	-

Results 1 - 3 of 3

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Release 2023.1 (January 2023)