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Information on EC 1.2.1.5 - aldehyde dehydrogenase [NAD(P)+]
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EC Tree
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]Specify your search results
Word Map
- 1.2.1.5
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aldhs
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retinoic
- disulfiram
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alcohol-induced
- benzaldehyde
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nadp+-dependent
- retinaldehyde
- cyanamide
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meta-cleavage
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aldh2*2
- phosphotransacetylase
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1.2.1.3
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hangover
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alcohol-related
- medicine
- energy production
- synthesis
- analysis
- degradation
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
acetaldehyde dehydrogenase, aldh3, aldh1a, myo-inositol dehydrogenase, class 3 aldehyde dehydrogenase, aldh9, tumor-associated aldehyde dehydrogenase, aldh2a, bcaldh, osaldh7, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ALD4
aldehyde dehydrogenase
aldehyde dehydrogenase 2
aldehyde: NAD(P)+ oxidoreductase
ALDH
Aldh1a3
ALDH2
ALDH3
ALDH3A1
Aldh3b1
ALDHIII
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BCP54
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Corneal 15.8 kDa protein
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Corneal protein 54
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dehydrogenase, aldehyde (nicotinamide adenine dinucleotide (phosphate))
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HTC-ALDH
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NAD(P)(+)-dependent aldehyde dehydrogenase
NAD(P)+-dependent aldehyde dehydrogenase
NAD+-dependent Ald4
nicotinprotein aldehyde dehydrogenase
PEG-ALDH
PuuC
ST0064
Transparentin
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Tumor-associated aldehyde dehydrogenase
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ybcD
aldehyde dehydrogenase
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ALDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+
ordered bi bi mechanism with NAD+ as the leading substrate
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an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
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reduction
oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
aldehyde:NAD(P)+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9028-88-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,3-dihydroxyacetone + NAD+ + H2O
? + NADH + H+
53.93% of the activity compared to acetaldehyde
-
-
?
1-formyl-6-methylpyrene + NADP+ + H2O
6-methylpyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
1-formyl-8-methylpyrene + NADP+ + H2O
8-methylpyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
1-formylpyrene + NADP+ + H2O
pyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
2,5-dihydroxybenzaldehyde + NADP+ + H2O
2,5-dihydroxybenzoate + NADPH + H+
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-
-
-
?
2-formylpyrene + NADP+ + H2O
pyrene-2-carboxylic acid + NADPH + H+
-
-
-
?
3,4-dihydroxymandelaldehyde + NAD+ + H2O
3,4-dihydroxyphenylmandelate + NADH + H+
-
-
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+
3,4-dihydroxyphenylacetate + NADH
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-
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
3,4-dihydroxyphenylacetate + NADH + H+
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?
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O
3,4-dihydroxyphenylglycolate + NADH + H+
-
-
-
?
3-hydroxybenzaldehyde + NADP+ + H2O
3-hydroxybenzoate + NADPH + H+
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-
-
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?
3-nitrobenzaldehyde + NAD+ + H2O
3-nitrobenzoate + NADH + H+
32.98% of the activity compared to acetaldehyde
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-
?
4-carboxybenzaldehyde + NADP+ + H2O
4-carboxybenzoate + NADPH + H+
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-
-
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?
4-chlorobenzaldehyde + NADP+ + H2O
4-chlorobenzoate + NADPH + H+
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-
-
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?
4-formylpyrene + NADP+ + H2O
pyrene-4-carboxylic acid + NADPH + H+
-
-
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?
4-hydroxy-2-nonenal + NADP+ + H2O
4-hydroxy-2-nonenoic acid + NADPH + H+
-
-
-
-
r
4-pyridinecarboxaldehyde + NAD+ + H2O
4-pyridinecarboxylate + NADH + H+
-
-
-
-
?
5-hydroxyindole-3-acetyldehyde + NAD+ + H2O
5-hydroxyindole-3-acetate + NADH + H+
-
-
-
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?
6-methoxy-2-naphthaldehyde + NADH + H+
(6-methoxynaphthalen-2-yl)methanol + NAD+
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-
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?
acetaldehyde + 3-pyridine aldehyde adenine dinucleotide phosphate
acetate + ?
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?
aldophosphamide + NAD+
N,N-bis-(2-chloroethyl)-diaminophosphoric-(2-carboxyethylester) + ?
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?
all-trans-retinol + NAD+ + H2O
all-trans-retinoic acid + NADH + H+
-
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?
all-trans-retinol + NADP+ + H2O
all-trans-retinoic acid + NADPH + H+
-
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?
D-glyceraldehyde + NAD+ + H2O
D-glycerate + NADH + H+
50.25% of the activity compared to acetaldehyde. kcat/KM for NAD+ with D-glyceraldehyde as cosubstrate is 3.8fold higher compared to NADP+
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?
D-glyceraldehyde + NADP+ + H2O
D-glycerate + NADPH
50.25% of the activity compared to acetaldehyde
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?
D-glyceraldehyde 3-phosphate + NAD+ + H2O
D-glycerate 3-phosphate + NADH + H+
52.7% of the activity compared to acetaldehyde
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?
DL-glyceraldehyde + NAD(P)+ + H2O
glycerate + NAD(P)H + H+
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14% of activity with benzaldehyde
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ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH + H+
75.43% of the activity compared to acetaldehyde
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-
?
heptanal + NADP+ + H2O
heptanoate + NADPH + H+
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-
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?
isovaleraldehyde + NADP+ + H2O
isovalerate + NADPH + H+
-
-
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?
n-tetradecanal + NADP+ + H2O
n-tetradecanoate + NADPH + H+
-
-
-
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?
p-hydroxybenzaldehyde + NADP+ + H2O
p-hydroxybenzoic acid + NADPH + H+
-
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?
polyethylene glycol 4000-aldehyde + NADP+
? + NADPH
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highest activtiy compared to other polyethylene glycolaldehydes
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?
propanal + 1,N6-ethenoadenine dinucleotide
propionate + ?
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isoenzyme E1 and E2
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-
?
propanal + 3-acetylpyridine adenine dinucleotide
propionate + ?
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isoenzyme E1 and E2
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-
?
propanal + 3-pyridine adenine dinucleotide
propionate + ?
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isoenzyme E1 and E2
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?
propanal + beta-NADP+ + H2O
propionate + beta-NADPH + H+
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isoenzyme E1 and E2
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?
propanal + oxidized nicotinamide hypoxanthine dinucleotide + H2O
propionate + reduced nicotinamide hypoxanthine dinucleotide
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isoenzyme E1 and E2
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?
propionaldehyde + 3-pyridinealdehyde adenine dinucleotide + H2O
propionate + reduced 3-pyridinealdehyde adenine dinucleotide + H+
-
-
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r
propionaldehyde + N-1,N6-ethenoadenine dinucleotide + H2O
propionate + reduced N-1,N6-ethenoadenine dinucleotide + H+
-
-
-
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?
retinal + NAD+ + H2O
retinoic acid + NADH + H+
preferred substrate of isozyme ALDH1A3
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-
?
valeraldehyde + NADP+ + H2O
valerate + NADPH + H+
-
-
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?
2-bromobenzaldehyde + NAD+ + H2O
2-bromobenzoate + NADH + H+
-
-
-
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?
2-chlorobenzaldehyde + NAD+ + H2O
2-chlorobenzoate + NADH + H+
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?
2-fluorobenzaldehyde + NAD+ + H2O
2-fluorobenzoate + NADH + H+
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-
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?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
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?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
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?
acetaldehyde + NAD(P)+ + H2O
acetate + NAD(P)H + H+
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51% of activity with benzaldehyde
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ir
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
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activity with the enzyme from stomach mucosa, no activity with the enzyme from breast adenocarcinoma cell line
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?