Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 1.2.1.5 - aldehyde dehydrogenase [NAD(P)+]

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Expression of ALDH3 and NMO1 in human corneal epithelial and breast adenocarcinoma cells.
Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.
Overexpression or polycyclic aromatic hydrocarbon-mediated induction of an apparently novel class 3 aldehyde dehydrogenase in human breast adenocarcinoma cells and its relationship to oxazaphosphorine-specific acquired resistance.
Adenocarcinoma of Lung
[Expression of Acetaldehyde Dehydrogenase in Gefitinib-resistant Human Lung Adenocarcinoma HCC-827/GR Cells].
[Increased expression of acetaldehyde dehydrogenase in cisplatin-resistant human lung adenocarcinoma A549/DDP cells].
Alcohol Withdrawal Delirium
Some biochemical aspects of chronic alcohol intoxication.
aldehyde dehydrogenase [nad(p)+] deficiency
Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults.
Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency.
Anophthalmos
A Novel Missense Mutation in the ALDH13 Gene Causes Anophthalmia in Two Unrelated Iranian Consanguineous Families.
Asthma
Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test.
The Pathogenesis of Alcohol-Induced Airflow Limitation in Acetaldehyde Dehydrogenase 2-Deficient Mice.
Bone Diseases, Metabolic
The Thiocarbamate Disulphide Drug, Disulfiram Induces Osteopenia in Rats by Inhibition of Osteoblast Function Due to Suppression of Acetaldehyde Dehydrogenase Activity.
Breast Neoplasms
Combined expression of aldehyde dehydrogenase 1A1 and ?-catenin is associated with lymph node metastasis and poor survival in breast cancer patients following cyclophosphamide treatment.
Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase.
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells.
Carcinogenesis
Aldehyde dehydrogenases and cell proliferation.
ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets.
ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.
Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat.
Structure of the 5' flanking region of class 3 aldehyde dehydrogenase in the rat.
The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract.
Carcinoma
Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.
Molecular genetics of human aldehyde dehydrogenase.
Carcinoma, Hepatocellular
Aldehyde dehydrogenase 3 expression is decreased by clofibrate via PPAR gamma induction in JM2 rat hepatoma cell line.
Aldehyde dehydrogenase 3 gene regulation: studies on constitutive and hypoxia-modulated expression.
Antisense oligonucleotides against aldehyde dehydrogenase 3 inhibit hepatoma cell proliferation by affecting MAP kinases.
Biochemical genetic analysis of human and rodent aldehyde dehydrogenase (ALDH).
Changes of CYP1A1, GST, and ALDH3 enzymes in hepatoma cell lines undergoing enhanced lipid peroxidation.
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3.
Comparative subcellular distribution of benzaldehyde and acetaldehyde dehydrogenase activities in two hepatoma cell lines and in normal hepatocytes.
Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells.
Cytochemical detection of a class 3 aldehyde dehydrogenase in human hepatocellular carcinoma.
Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
Expression of tumor-associated aldehyde dehydrogenase gene in rat hepatoma cell lines.
Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.
Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli.
Hypoxia exerts cell-type-specific effects on expression of the class 3 aldehyde dehydrogenase gene.
Immunohistochemical study of hepatocellular carcinoma-specific aldehyde dehydrogenase.
Induction of class 3 aldehyde dehydrogenase in the mouse hepatoma cell line Hepa-1 by various chemicals.
Inhibition of cytosolic class 3 aldehyde dehydrogenase by antisense oligonucleotides in rat hepatoma cells.
Primary structure of human hepatocellular carcinoma-associated aldehyde dehydrogenase.
Purification and immunochemical characterization of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas.
The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death.
The subcellular distribution and properties of aldehyde dehydrogenase of hepatoma AH-130.
Cardiotoxicity
ALDH2 attenuates Dox-induced cardiotoxicity by inhibiting cardiac apoptosis and oxidative stress.
Cardiovascular Diseases
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Cholangiocarcinoma
Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma.
Colitis
Protective Effects of ALDH1A Enzyme Inhibition on Helicobacter-Induced Colitis in Smad3-/- Mice are Associated with Altered ?4ß7 Integrin Expression on Activated T Cells.
Colitis, Ulcerative
Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease.
Colonic Neoplasms
ALDH1A inhibition sensitizes colon cancer cells to chemotherapy.
Colorectal Neoplasms
ALDH1A inhibition sensitizes colon cancer cells to chemotherapy.
Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer.
Coronary Artery Disease
The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu > Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese.
Crohn Disease
Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease.
Dermatitis, Atopic
Detection of down-regulated acetaldehyde dehydrogenase 1 in atopic dermatitis patients by two-dimensional electrophoresis.
Diabetes Mellitus
Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study.
Diabetic Retinopathy
ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway.
Endometriosis
Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma.
Esophageal Squamous Cell Carcinoma
Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.
Essential Hypertension
Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study.
Fatty Liver
Role of hepatic acetaldehyde dehydrogenase in alcoholism: demonstration of persistent reduction of cytosolic activity in abstaining patients.
[Disulfiram-like reactions resulting from the administration of cephem antibiotics with methyltetrazolethiol moiety examined by using different doses]
Fatty Liver, Alcoholic
Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
Glioblastoma
[Adherent culture of CD133+ cells in glioblastomas and expression of ADLH1].
Glioma
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
Hallucinations
Some biochemical aspects of chronic alcohol intoxication.
Head and Neck Neoplasms
A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth.
Heart Failure
Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells.
Hepatitis B
Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency.
Hepatitis, Alcoholic
Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
Hypersensitivity
Allergic and intolerance reactions to wine.
Hypertension
Acetaldehyde Dehydrogenase 2 rs671 Polymorphism Affects Hypertension Susceptibility and Lipid Profiles in a Chinese Population.
Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population.
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
[Effects of ethanol on the nervous and vascular systems: the mechanisms of alcohol-induced hypertension]
Infections
LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species.
Secreted Listeria adhesion protein (Lap) influences Lap-mediated Listeria monocytogenes paracellular translocation through epithelial barrier.
[Improvement of combination chemotherapy tolerance of human umbilical cord blood CD(34)(+) cells transducted with double drug resistance genes by a bicistronic retroviral vector]
Iron Deficiencies
The Metabolic Status Drives Acclimation of Iron Deficiency Responses in Chlamydomonas reinhardtii as Revealed by Proteomics Based Hierarchical Clustering and Reverse Genetics.
Leukemia
Sphere-forming-like cells (squamospheres) with cancer stem-like cell traits from VX2 rabbit buccal squamous cell carcinoma.
Liver Cirrhosis, Alcoholic
Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice.
Liver Diseases
Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
Melanoma
ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets.
Malignant melanoma: diagnosis, treatment and cancer stem cells.
Myoma
Acetaldehyde differentially affects the growth of uterine leiomyomata and myometrial cells in tissue cultures.
Neoplasms
?,?-Acetylenic Amino Thiolester Inhibitors of Aldehyde Dehydrogenases 1&3: Suppressors of Apoptogenic Aldehyde Oxidation and Activators of Apoptosis.
Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention.
Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes.
ALDH1A inhibition sensitizes colon cancer cells to chemotherapy.
Antisense oligonucleotides against aldehyde dehydrogenase 3 inhibit hepatoma cell proliferation by affecting MAP kinases.
Class 1 and class 3 aldehyde dehydrogenase levels in the human tumor cell lines currently used by the National Cancer Institute to screen for potentially useful antitumor agents.
Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Expression profile of intestinal stem cell and cancer stem cell markers in gastric cancers with submucosal invasion.
Functional study of acetaldehyde dehydrogenase 1 (ALDH1) in keratinocytes: Microarray integrating bioinformatics approaches.
Inhibition of cytosolic class 3 aldehyde dehydrogenase by antisense oligonucleotides in rat hepatoma cells.
Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues.
Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol.
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.
Integration of Inhibition Kinetics and Molecular Dynamics Simulations: A Urea-Mediated Folding Study on Acetaldehyde Dehydrogenase 1.
Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat.
Properties of lewis lung carcinoma cells surviving curcumin toxicity.
Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions.
Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae.
Regulatory T cells promote glioma cell stemness through TGF-?-NF-?B-IL6-STAT3 signaling.
Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer.
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Substrate preference of a cytosolic aldehyde dehydrogenase inducible in rat liver by treatment with 3-methylcholanthrene.
The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.
The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract.
The role of acetaldehyde in upper digestive tract cancer in alcoholics.
The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice.
Tumor-associated aldehyde dehydrogenase (ALDH3): expression in different human tumor cell lines with and without treatment with 3-methylcholanthrene.
[Expression of Acetaldehyde Dehydrogenase in Gefitinib-resistant Human Lung Adenocarcinoma HCC-827/GR Cells].
Obesity
Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity.
Pneumonia
Deletion of ldhA and aldH genes in Klebsiella pneumoniae to enhance 1,3-propanediol production.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours.
Prostatic Neoplasms
Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture.
Squamous Cell Carcinoma of Head and Neck
Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.
Starvation
Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae.
Stroke
ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway.
Tachycardia
Impact of Flushing Response on the Relationship between Alcohol Consumption and Gamma-glutamyl Transpeptidase: the KOBE study.
Vitiligo
Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection.