Any feedback?
Information on EC 1.1.1.47 - glucose 1-dehydrogenase [NAD(P)+]
for references in articles please use BRENDA:EC1.1.1.47Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]IUBMB Comments
This enzyme has similar activity with either NAD+ or NADP+. cf. EC 1.1.1.118, glucose 1-dehydrogenase (NAD+) and EC 1.1.1.119, glucose 1-dehydrogenase (NADP+).
Specify your search results
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
hexose-6-phosphate dehydrogenase, glcdh-i, glcdh-ii, ssgdh, glcdh-iwg3, bmglcdh-iv, lsgdh, bzgdh, hexose phosphate dehydrogenase, nad(p)-dependent glucose dehydrogenase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alkali-resistant glucose 1-dehydrogenase
beta-D-glucose:NAD(P)+ 1-oxidoreductase
-
-
-
-
bzgdh
D-glucose dehydrogenase (NAD(P))
-
-
-
-
EC 1.1.5.2
GDH
GDHB
general stress protein 74
-
-
-
-
GlcDH
GlcDH-I
GlcDH-II
GlcDH-IWG3
glucose 1-dehydrogenase
glucose 1-dehydrogenase 3
glucose 1-dehydrogenase B
glucose dehydrogenase
GluDH
GSP74
-
-
-
-
hexose phosphate dehydrogenase
-
-
-
-
hexose-6-phosphate dehydrogenase
LsGDH
NAD(P)-dependent glucose 1-dehydrogenase
NAD(P)-dependent glucose-1-dehydrogenase
NAD-GDH
nicotinamide adenine dinucleotide (NAD)-linked glucose dehydrogenase
SSO3204
additional information
GDH
-
-
-
-
GlcDH
-
-
-
-
hexose-6-phosphate dehydrogenase
-
-
-
-
nicotinamide adenine dinucleotide (NAD)-linked glucose dehydrogenase
-
-
nicotinamide adenine dinucleotide (NAD)-linked glucose dehydrogenase
-
-
-
additional information
-
enzyme belongs to the family of short-chain dehydrogenases/reductases
additional information
-
enzyme belongs to the family of short-chain dehydrogenases/reductases
additional information
-
enzyme belongs to the family of short-chain dehydrogenases/reductases
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
-
D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
ordered bi bi mechanism
-
D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
sequential ordered bi-bi mechanism
-
D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
ordered bi bi mechanism, formation of ternary complexes, NADP+ adds first, NADPH formed dissociates last, for reverse reaction, NADPH adds first, NADP+ leaves last
-
D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
sequential type ordered bibi mechnanism
-
D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
sequential ordered bi-bi mechanism
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
D-glucose:NAD(P)+ 1-oxidoreductase
This enzyme has similar activity with either NAD+ or NADP+. cf. EC 1.1.1.118, glucose 1-dehydrogenase (NAD+) and EC 1.1.1.119, glucose 1-dehydrogenase (NADP+).
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9028-53-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-amino-2-deoxy-D-glucose + NADP+
2-amino-2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
5% of the activity with D-glucose and NAD+
-
-
?
2-deoxy-beta-D-xylose + NAD+
2-deoxy-D-xylono-1,5-lactone + NADH + H+
-
-
-
-
r
2-deoxy-D-glucose 6-phosphate + NAD+
2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADH
-
-
-
-
?
2-deoxy-D-glucose 6-phosphate + NADP+
2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADPH
-
-
-
-
?
6-deoxy-D-glucose + NAD+
6-deoxy-D-glucono-1,5-lactone + NADH + H+
-
66% of the activity with D-glucose
-
-
?
6-deoxy-D-glucose + NADP+
? + NADPH
-
9% of the activity with D-glucose and NAD+
-
-
?
beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH + H+
-
-
-
-
?
beta-D-glucose + NAD(P)(+)
D-glucono-1,5-lactone + NAD(P)H
the enzyme might represent the major player in glucose catabolism via the branched Entner-Doudoroff pathway
-
-
ir
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH
the enzyme is absolutely specific for glucose. D-Galactose, D-allose, D-mannose, D-xylose, L-arabinose, D-ribose, D-xylose, D-arabinose, L-xylose, D-glucosamine, 2-deoxy-D-glucose, D-fucose, D-lactose, D-maltose, D-fructose and ethanol are not used as substrates. the catalytic efficiency for the reaction with beta-D-glucose and NADP+ (kcat/Km) is 7.8 fold higher compared to catalytic efficiency for the reaction with beta-D-glucose and NAD+
-
-
ir
beta-D-glucose + NADP+
D-glucono-1,5-lactone + NADPH
the enzyme is absolutely specific for glucose. D-Galactose, D-allose, D-mannose, D-xylose, L-arabinose, D-ribose, D-xylose, D-arabinose, L-xylose, D-glucosamine, 2-deoxy-D-glucose, D-fucose, D-lactose, D-maltose, D-fructose and ethanol are not used as substrates. the catalytic efficiency for the reaction with beta-D-glucose and NADP+ (kcat/Km) is 7.8 fold higher compared to catalytic efficiency for the reaction with beta-D-glucose and NAD+
-
-
ir
beta-D-glucose 6-phosphate + NAD+
D-glucono-1,5-lactone 6-phosphate + NADPH
-
-
-
-
?
beta-D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
26% activity compared to D-glucose
-
-
r
D-allose + NAD+
D-allono-1,5-lactone + NADH
-
8% of the activity with D-glucose
-
-
?
D-allose + NADP+
D-allono-1,5-lactone + NADPH
-
13% of the activity with D-glucose and NAD+
-
-
?
D-altrose + NAD+
D-altrono-1,5-lactone + NADH
-
5% of the activity with D-glucose
-
-
?
D-altrose + NADP+
D-altrono-1,5-lactone + NADPH
-
12% of the activity with D-glucose and NAD+
-
-
?
D-fructose + NAD(P)+
? + NAD(P)H
-
no activity with mutants Q252L and Q252L/E170K
-
-
?
D-fructose + NADP+
?
-
0.03% activity compared to D-glucose
-
-
?
D-galactose + NADP+
?
-
1.09% activity compared to D-glucose
-
-
?
D-galactose 6-phosphate + NAD+
6-phospho-D-galactono-1,5-lactone + NADH + H+
-
-
-
-
r
D-galactose 6-phosphate + NADP+
6-phospho-D-galactono-1,5-lactone + NADPH + H+
-
-
-
-
r
D-glucose + 1-(3-phenylpropyl)-1,4-dihydropyridine-3-carboxamide
D-glucono-1,5-lactone + reduced 1-(3-phenylpropyl)-1,4-dihydropyridine-3-carboxamide
-
-
-
?
D-glucose + 1-benzyl-3-carbamoylpyridin-1-ium chloride
D-glucono-1,5-lactone + reduced 1-benzyl-3-carbamoylpyridin-1-ium chloride
-
-
-
?
D-glucose + 1-phenethyl-1,4-dihydropyridine-3-carboxamide
D-glucono-1,5-lactone + reduced 1-phenethyl-1,4-dihydropyridine-3-carboxamide
-
-
-
?
D-gulose + NAD+
D-gulono-1,5-lactone + NADH
-
8% of the activity with D-glucose
-
-
?
D-gulose + NADP+
D-gulono-1,5-lactone + NADPH
-
12% of the activity with D-glucose and NAD+
-
-
?
D-idose + NAD+
D-idono-1,5-lactone + NADH
-
65% of the activity with D-glucose
-
-
?
D-idose + NADP+
D-idono-1,5-lactone + NADPH
-
12% of the activity with D-glucose and NAD+
-
-
?
D-lactose + NAD+
D-lactono-1,5-lactone + NADH + H+
relative activity: 4.2%
-
-
?
D-lactose + NADP+
?
-
3.0% activity compared to D-glucose
-
-
?
D-maltose + NADP+
?
-
1.03% activity compared to D-glucose
-
-
?
D-mannose + NADP+
?
-
11.53% activity compared to D-glucose
-
-
?
D-ribose + NADP+
D-ribono-1,5-lactone + NADPH
-
4% of the activity with D-glucose and NADP+
-
-
?
D-xylose + NADP+
?
-
12.89% activity compared to D-glucose
-
-
?
2-amino-2-deoxy-D-glucose + NAD+
2-amino-2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
14% of the activity with D-glucose
-
-
?
2-amino-2-deoxy-D-glucose + NAD+
2-amino-2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
26% of the activity with D-glucose
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
113% of the activity with D-glucose
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
Bacillus sp. (in: Bacteria) BG 1722
-
113% of the activity with D-glucose
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
108% of the activity with D-glucose
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
114% of the activity with D-glucose
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
112% relative activity
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
Priestia megaterium M1286
-
112% relative activity
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
12% of the activity with glucose
-
-
?
2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
103% of the activity with D-glucose and NAD+
-
-
?
2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
Bacillus sp. (in: Bacteria) BG 1722
-
103% of the activity with D-glucose and NAD+
-
-
?
2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
-
-
-
?
2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
-
-
-
?
2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
25% of the activity with D-glucose and NAD+
-
-
?
beta-D-galactose + NAD+
D-galactono-1,5-lactone + NADH
6.8% of the activity as compared to D-glucose
-
-
?
beta-D-galactose + NAD+
D-galactono-1,5-lactone + NADH
6.8% of the activity as compared to D-glucose
-
-
?
beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH
-
-
-
-
?
beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH
-
-
-
?
beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH
-
low activity
-
-
?
beta-D-glucose + 2,6-dichlorophenol-indophenol
?
-
-
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
enzyme plays a role in germination
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
enzyme plays a role in germination
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
multifunctional enzyme is involved in several catabolic sugar pathways in the endoplasmic reticulum
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
ir
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
best substrate, wild-type and mutant enzymes
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
ir
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
first step of the non-phosphorylative Entner-Doudoroff pathway
-
-
ir
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
-
?
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
-
-
-
-
?
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
velocities of the reverse reaction at pH 7.0 and 8.0 are 2.2% and 5.9% respectively, of the oxidative reaction
-
-
r
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
5.9% velocity for reverse reaction compared to forward reaction at pH 8.0
-
-
r
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
velocities of the reverse reaction at pH 7.0 and 8.0 are 2.2% and 5.9% respectively, of the oxidative reaction
-
-
r
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
5.9% velocity for reverse reaction compared to forward reaction at pH 8.0
-
-
r
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
about 3times more active with NADP+ than with NAD+
-
-
?
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
about 3times more active with NADP+ than with NAD+
-
-
?
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
although they can utilize both NAD+ and NADP+: GlcDH-III and GlcDH-IV prefer NAD+, and GlcDH-I and GlcDH-II prefer NADP+
-
-
?